Báo cáo khoa học: Theoretical study of lipid biosynthesis in wild-type Escherichia coli and in a protoplast-type L-form using elementary ﬂux mode analysis potx

... to lipid A, lipid A cold-adaptedform [lipid A (ca)], L1-phosphatidylethanolamine(L1-P-EtAmine), and cardiolipin. An example of a core mode is an EFM that produces lipid A without using any of ... enzymes FabD, FabH_2, FabB_3, and AccACD. In this cycle, acetyl-CoA is carboxylated(driven by ATP hydrolysis) and decarboxylated again(Fig. 2). The remaining EFMs are capable of producingall of ... biosynthesis in wild-type Escherichia coli and in a protoplast-type L-form using elementary ﬂux mode analysis Dimitar Kenanov1,*,, Christoph Kaleta1,*, Andreas Petzold2, Christian Hoischen3,...

Báo cáo khoa học: NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B–NS3 protease ppt

... occurs in Africa, Europe and Asia and, since 1999, has also been spreading in NorthAmerica, causing several thousand cases per year, with a fatality rate of 5%, as reported by the US Depart-ment ... activity and with inhibitors that targetthe substrate-binding site. Indeed, the G15 1A mutantwas inactive in the enzymatic assay [25] and unable tobind 3 (Fig. S6).Having established that compound ... Subhash G. Vasudevan2,* and Gottfried Otting11 Research School of Chemistry, Australian National University, Canberra, Australia2 Novartis Institute for Tropical Diseases, Singapore3 Department...

Báo cáo khoa học: Detailed structure of lipid A isolated from lipopolysaccharide from the marine proteobacterium Marinomonas vaga ATCC 27119T pot

... structural analysis of lipid A from the Marinomonas vaga AT CC 27119TLPS. M. vaga(formerly known as Alteromonas vaga) was ﬁrst isolatedfrom sea water off the coast of the Hawaii an archipelago in ... fatty acids [7]. On the otherhand, according t o data available so far, lipid A structuralvariants displaying high endotoxin antagonism have a disaccharide or monosaccharide backbone, mainly ... performed in a ccordance with thePaciﬁc Institute of B ioorganic Chemistry Policy o n HumanCare and Use of Laboratory Animals.ResultsIsolation and characterization of lipid A fromM. vagaExtraction...

Báo cáo khoa học: "Empirical Study of Predictive Powers of Simple Attachment Schemes for Post-modifier Prepositional Phrases" pptx

... syntac- tic attachment interpretations and actual interpre- tations that occurred. For instance in the sentence John eats his bananas in his backyard, potential at- tachment ambiguity lies in ... terminal to a human-assisted travel information system located in a separate room. In response to this, the Wizard, who had access to both computerized and hard- copy travel data, was instructed ... that they can easily be made to fail by manipulating parameters that they 'know' nothing about, such as semantics, context, and intonation. Clearly, more elaborate schemes for attachment...

Báo cáo khoa học: Structural study of the catalytic domain of PKCf using infrared spectroscopy and two-dimensional infrared correlation spectroscopy pot

... Murcia, SpainProtein kinase C (PKC) is a family of related proteinkinases that plays an important role in regulating cellgrowth. These protein kinases are involved in severalintracellular pathways ... & Thompson MP (1991) Infra-red spectroscopic discrimination between alpha- and 3(10)-helices in globular proteins. Reexamination of amide I infrared bands of alpha-lactalbumin and theirassignment ... subtracting twoabsorption spectra using a factor that resulted in the 1700–1600 cm)1interval (amide I) having identical positive and negative area.2D correlation analysis was carried out using...

Báo cáo khoa học: Kinetic study of the HIV)1 DNA 3¢-end processing Single-turnover property of integrase docx

... Gelswere analysed on a STORM 840 PhosphorImager (Molecu-lar Dynamics, Sunnyvale, CA, USA) and quantiﬁed using image quant 4.1 software. Analysis of kinetic data and determination of apparent Km and ... turnover of IN Taking into account the standard duration of 3¢-pro-cessing assays, the absence of turnover in the case of IN originates primarily in the low kcat¢ value. Theamount of IN DNA complex, ... evidence that suchnonviralviral A BCAGTnonviralviral IN Catalyticcore of IN inactiveactiveCinactive activeININFig. 7. Schematic diagram of three models compatible with the for-mation of the...

Báo cáo khoa học: The study of G-protein coupled receptor oligomerization with computational modeling and bioinformatics doc

... molecular details of signaling.Structural details from computationalmodeling and bioinformaticsAs anticipated above, structural details from computa-tional modeling and bioinformatics may provide ... Theory of Communication. University of Illinois press, Champaign,IL.81 Pazos F, Sanchez-Pulido L, Garcia-Ranea JA, AndradeMA, Atrian S & Valencia A (1997) Comparative analy-sis of different ... & Fingleton B (1985) Spatial Data Analysis byExample. Wiley, Chichester.58 Fraczkiewicz R & Braun W (1998) Exact and efﬁcientanalytical calculation of the accessible surface areas and their...

Báo cáo khoa học: "Theoretical Evaluation of Estimation Methods for Data-Oriented Parsing" pot

... distributions.t1= S A a A bt2= S A b A at3= S A a A at4= S A b A bt5=S A a A t6=S A Abt7=S A b A t8=S A A a t9=S A At10 =A at11 =A bFigure 2: Counter-example to the correction-factor ... S A a A at2=S A a A t3=S A A a t5=S A at4=S A At6= S A t7 =A aFigure 1: The example of (Johnson, 2002)(Johnson, 2002) looks at an example grammarG ∈ STSG with the subtrees as in ... approach to statistical parsingknown as “Data-Oriented Parsing” (Scha, 1990;Bod, 1998). In this approach the subtrees of thetrees in a tree bank are used as elementary trees of the grammar. In most...

Báo cáo khoa học: Proteomic characterization of lipid raft proteins in amyotrophic lateral sclerosis mouse spinal cord pot

... proce-dures. A ratio was calculated for each peptide identi-ﬁed in WT and G9 3A samples, and an average ratio of all peptides for every protein was then obtained asthe protein ratio in each pair of lipid ... functions,such as vesicular transport, neurotransmitter synthesis and release; cytoskeletal organization, and linkage tothe plasma membrane; metabolism; and microgliaactivation and in ammation. Many of ... SOD1 and transgenically overexpressed human WT and G9 3A Fig. 5. Increased plasma membrane stain-ing of annexin II in G9 3A motor neurons.Immunoﬂuorescent staining of annexin II and the neuronal...

Báo cáo khoa học: NMR study of cellulose and wheat straw degradation by Ruminococcus albus 20 pdf

... standard.aArafXyl, a- arabinofuranose linked to O2, O3 or O2, O3 of xylose unit; Arap, arabinopyranose; CB, cellobiose; CD, cellodextrin; aGalfMan, a- galactofuranose in galactomannan or arabinogalactan; Glc, ... results may be explained by a greater efﬁciency of F. succinogenes in hemicellulose degradation and, in particular, its arabinofuranosidase and xylanases. In addition, F. succinogenes accumulated ... usually less than 15%.Ara; aAraXyl; a and b CBredor a and b cellodextrins (CDred);CDint; aGalfMan; a and b Glc; Glc-IP; GlcXyl; X2;Xyl; Xylint.Degradation of wheat straw by R. albus...

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