Báo cáo khoa học: Multidrug efflux pumps: The structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues ppt

... All of the tumor types were confirmed by pathologic analysis. The experiments were undertaken with the understanding and written consent of each subject. The study methodologies conformed to the ... After incubation for 24, 48 and 72 h, the cells were incubated with 20 lL of MTT (at a final concentration of 0.5 mgÆmL )1 )at37°C for 4 h. The medium was removed an...

Ngày tải lên: 18/02/2014, 04:20

... ends, and in particular at the barbed end [23]. On the other hand, Pi has a negli- gible effect on the critical concentration for polymeriza- tion of F-actin in the presence of ATP, because of the protective ... digestions of F-actin revealed that after 30 s incubation with cofilin at pH 8.0 the rate and the extent of actin cleavage was the same in the presenc...

Ngày tải lên: 19/02/2014, 07:20

... completing the catabolism of the pyrrolidine moiety of nicotine. Expression of the genes of these enzymes was dependent on the presence of nicotine in the growth medium. Thus, two enzymes of the nicotine ... expression of these genes depends on the presence of nicotine in the growth medium and we have determined the enzyme activities of the proteins. O...

Ngày tải lên: 19/02/2014, 07:20

... 7. The arrows labeled (b) and (c) point to the areas of interaction between the transmembrane helix of subunit 8 and helices G and H1 of cytochrome b and between the N-terminus of subunit 8 and ... panels A and B and the relative amounts of each of the subunits determined by densitometry scanning of the stained Western blots of the q° and CKL57...

Ngày tải lên: 19/02/2014, 12:20

... thus on the one hand fully support these previous findings and on the other hand extend them by far and set them in a more general context, as both a-subunits of P4h, PDI as the b-subunit of P4h ... clear twofold increase of PDI mRNA, a more moderate increase of the mRNAs for prolyl hydroxylases, and did not increase the mRNA abundance of the other enzymes. Discus...

Ngày tải lên: 20/02/2014, 02:21

... activation of Ga 16 and Ga q subunits. Therefore the lack of change in the rate of degradation cannot be due to lack of receptor-activa- tion of the alpha subunits. Given that the activation of G proteins ... immunoprecipitates and the arrowheads indicate the position of Ga q and Ga 16 . The molecular mass standards are indicated. The arrow indicates the...

Ngày tải lên: 20/02/2014, 03:20

... chelators on the uptake and fate of NTBI and to investigate the potential of these chelators for therapeutic use in Fe overload diseases and cancer chemotherapy. Desferrioxamine (DFO), the only chelator ... reactions essential for growth and proliferation, is uncertain. Hence, it is of interest to investigate the uptake and metabolism of NTBI in normal and canc...

Ngày tải lên: 20/02/2014, 11:20

... switch and alters the expression of the two nuclear genome coded isoforms of CytOX V [10,32]. The regulation of genes CytOX5a and CytOX5b, coding for the two isofoms Va and Vb, parallels that of ... with the latterexpressedinanO 2 and heme regulated manner. In this study therefore, we investigated how O 2 modulates the expression of mRNAs for CytOX subunits...

Ngày tải lên: 20/02/2014, 23:20

... represents a window of two words to the left and four words to the right of the candidate noun-noun sequence. Table 5 shows the performance of the two classifiers for some of the contextual feature ... between one and four words be- fore and after the candidate compounds. We use symbols 1 and r for left and right context, respec- tively and number to de...

Ngày tải lên: 22/02/2014, 02:20

... critical for the survival of developing B lym- phocytes and the maturation of spleen B cells [41–43]. Abnormal activation of NF-jB has been shown to be a hallmark of the development and progression of ... Tec transcription via the NF-jB signaling pathway. These findings provide further insight into the transcriptional regulation of the TFKs and the role of N...

Ngày tải lên: 07/03/2014, 00:20