Báo cáo khoa học: Multidrug efflux pumps: drug binding – gates or cavity? Emily Crowley and Richard Callaghan pdf

... Crowley and R. Callaghan Drug binding – gates or cavity? FEBS Journal 277 (2010) 53 0–5 39 ª 2009 The Authors Journal compilation ª 2009 FEBS 539 MINIREVIEW Multidrug efflux pumps: drug binding – gates ... characterize drug binding Result: Proposed several key residues from TM1, TM5 and TM6 in drug binding Drug binding – gates or cav...

Ngày tải lên: 22/03/2014, 21:20

... Journal 277 (2010) 54 0–5 49 ª 2009 The Authors Journal compilation ª 2009 FEBS 549 MINIREVIEW Multidrug efflux pumps: Substrate selection in ATP -binding cassette multidrug efflux pumps – first come, first ... division of Keywords ABCB1; ABC transporter; ATP hydrolysis; kinetic substrate selection; ligand binding; multidrug efflux; multidrug resistance; Pdr5; TAP; transport...

Ngày tải lên: 22/03/2014, 21:20

... 2.8 5.5 0.6 ± 0.3 ) – b ⁄ a ND (> 3) 14 ± 6 0.3 ± 0.3 – – – D70G: I or A type LA LA LCI LCI HA + PCI HA + PCI d K a (mM) 9.1 ± 1.9 ND a – ND c 0.015 ± 0.015 K i (mM) – – 12.5 ± 1 7.9 ± 0.4 ... o-NAC Wild-type: I or A type HA HA HCI LCI PCI HA + PCI K a (mM) 1 ± 0.3 0.8 ± 0.2 – – – b 0.03 ± 0.01 K i (mM) – – 1.7 ± 0.5 7.7 ± 0.2 0.18 ± 0.02 0.37 ± 0...

Ngày tải lên: 18/02/2014, 17:20

... Introduction Single scan algorithms ofparsing are important for interactive applications of NLP. For instance, such algorithms would be more suitable for robots ac- cepting speech inputs or chatbots handling natural language ... bunsetsus. A bunsetsu is a base phrasal unit and consists of one or more content words fol- lowed by zero or more function words. In addition, most of algorit...

Ngày tải lên: 17/03/2014, 02:20

... Extraction of Statistic Information from Corpus First, for each of 100 verbs selected by order of frequency in the KLIB (Korean Language In- formation Base) corpus of 6 million words, its syntactic ... an antecedent cannot be determined by word order. This is because Korean is a rel- atively free word-order language like Japanese, Russian, or Finnish, and also because some ar- gu...

Ngày tải lên: 17/03/2014, 07:20

... used for sulfate struc- tures [open for sulfate_1* (see Experimental procedures), filled for sulfate_3], green triangles for PAH complexes (open for PAH_1, filled for PAH_2), a magenta square for ... structure and an orange diamond for the FPAH complex. Black dots mark the PEP + 2 Mg trajectory and red dots the single Mg trajectory start- ing from the same PEP complex protein conformation....

Ngày tải lên: 23/03/2014, 07:20

... min) for the oligonucleotides and 8–7 0% B ( 0–1 5 min) for the oligonucleotide peptide conjugates. Before HPLC purifica- tion, the respective oligonucleotide–dithiothreitol or –pep- tide reaction mixtures ... conjugates. Cellular uptake of the 24- and the 15-mer PTO complexed or conjugated with I After exposing bovine aortic endothelial cells to the 24- and 15-mer PTOs and the...

Ngày tải lên: 23/03/2014, 21:21

... ATP -binding cassette transporter research is a structural understanding of drug binding and transport in a eukaryotic multidrug resistance pump. These transporters are front-line mediators of drug ... prokaryotic ATP -binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues Ian D. Kerr 1 , Peter M. Jones 2...

Ngày tải lên: 22/03/2014, 21:20

... N, terminal alphabet Σ, and rules of the form A → B C and A → x. (We assume Chomsky nor- mal form for clarity; the generalization is straight- forward.) Let r A (B C) and r A (x) denote the proba- bilities ... can follow y (3 for O and y 0 = start, 4 for B and I). p uni are the tag and word unigram distri- butions, estimated using MLE with add-1 smooth- ing. This model ignores tem...

Ngày tải lên: 20/02/2014, 12:20

... one extra copy sorted in position 1, for all the trigrams, we need two extra copies; one sorted in position 1, and an- other sorted in position 2, and so forth. Hence, in order to handle the contiguous ... System Demonstrations, pages 10 3–1 08, Portland, Oregon, USA, 21 June 2011. c 2011 Association for Computational Linguistics An Efficient Indexer for Large N-Gram Corpora Hakan Ceyla...

Ngày tải lên: 07/03/2014, 22:20