Báo cáo khoa học: Activation, regulation, and inhibition of DYRK1A Walter Becker1 and Wolfgang Sippl2 pptx

... ª 2010 FEBS MINIREVIEW Activation, regulation, and inhibition of DYRK1A Walter Becker 1 and Wolfgang Sippl 2 1 Institute of Pharmacology and Toxicology, Medical Faculty of the RWTH Aachen University, ... [17]. Harmine inhibits DYRK1A in cultured cells with simi- Fig. 3. Chemical structures of known DYRK1A inhibitors. W. Becker and W. Sippl Activation, regula...

Ngày tải lên: 22/03/2014, 16:21

... dif- ferences between 4 and 7 and, finally, models with D i < 2 are considered to be all equally plausible. In light of the heuristic rules of Burnham & Ander- son, the most plausible inhibition mechanism ... S 2 · (n–p 1 ) ⁄ (p 2 –p 1 ). Here, S 1 and S 2 are the two residual sums of squares, p 1 and p 2 are the corresponding number of adjustable model parameters and...

Ngày tải lên: 19/02/2014, 06:20

... N e . The crystal structures of K328 ⁄ K328A–C12 and K328R and the results of the decarboxylation assays of the ‘bulky’ mutants all point to the orientation of H333 and its hydrogen bond donor ... crystal structures of both CHH and CHN enzymes [1,4,5,11,12] have contributed to the under- standing of the role of conserved residues in the active site of CHH condensing en...

Ngày tải lên: 19/02/2014, 08:20

... comparison of band absorbance. Absence of a sharp and convoluted spectral band around 3600–3000 cm )1 in the spectra of both chitosan and LMWC indicated the absence of free -OH groups and the involvement ... linear polysaccharide of b1fi4-linked 2-deoxy-2-acetamido- D -glu- cose units [1], that constitutes the exoskeleton of inverte- brates and is one of the components o...

Ngày tải lên: 19/02/2014, 12:20

... -III, -V and -VI genes and abolishment of transcription of the b4GalT-IV gene [32]. Second, comparison of DNA microarray-based expression profiles between specimens of pancreatic cancer and normal ... expres- sion levels of three b4GalT proteins, explicitly down- regulation of gene expression for proteins I and V and up-regulation of protein IV. Of note, transcription...

Ngày tải lên: 16/03/2014, 10:20

... inhibitor of glucosidases I and II. In the presence of castanospermine, the levels of both Glc1Man9GlcNAc2 and peak X were increased (Fig. 2A,B). Under these conditions, the decreasing amounts of Man9GlcNAc2 ... the presence of kifunensine, an inhibitor of the demannosylation process. Figure 1D,H shows that incubation in the presence of 20 l M kifunensine did not affect the...

Ngày tải lên: 16/03/2014, 16:20

... Levin 2 1 Laboratory of Cell Biology, National Heart, Lung, and Blood Institute and 2 Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, ... spectroscopic bandwidths are functions of dynamic parameters derived from intermolecular and intramolecular motions. Band shapes are often analyzed in the c...

Ngày tải lên: 17/03/2014, 03:20

... result of the presence of negatively-charged residues at P2 and P2¢ that are not accommodated within the b2-tryptase active site because of the presence of Asp147 and Asp143 within the S2 and the ... specificity of CG and chymase Crystallographic data show that the S2¢ subsite of CG is highly polar as a result of the presence of three posi- tively-charged residues: Arg4...

Ngày tải lên: 28/03/2014, 22:20

... signalling of NF-jB and the damping function of OPTN in signalling feedback of NF-jB. The knowledge about the direct action of NF-jBon OPTN will greatly enhance our understanding of the signalling ... match of a transfac consensus motif of NF-jB) in the 500 bp upstream of the transcription start site and were members of the upper 5% in the rank. The resulting list is sho...

Ngày tải lên: 18/02/2014, 18:20

... similarity of noun-noun and verb-verb pairs (Sinha and Mihalcea, 2007; Guo and Diab, 2010). Our similarity measure wmfvec exploits the same information (sense defini- tions) elesk and ldavec use, and ... select the best of them and com- bine them into one system. Specifically, in their im- plementation they use jcn for noun-noun and verb- verb pairs, and elesk for other pair...

Ngày tải lên: 19/02/2014, 19:20