Báo cáo khoa học: Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases pot

... on the RDDP activity; (b) the K-126 analogue, which was slightly active on the wild-type RT RNase H function, showed a sixfold increase in the inhibition potency of the RNase H function, although ... selectively hydrolyzes the RNA strand of the RNA :DNA hybrid formed during synthesis of the minus (–) strand DNA that uses (+)-strand RNA as template [2,3]...

Ngày tải lên: 22/03/2014, 16:20

... modulated both individually and simultaneous by changing the expression of the respective genes. We found that nei- ther the individual enzymes nor the sum of the las enzymes had significant control on the ... by PFK, PK and LDH. The role of the las operon is dis- cussed on the basis of the distribution of flux control for PFK, PK and LDH. Results PFK has...

Ngày tải lên: 19/02/2014, 17:20

... disadvantageous in the base context C2PT (III) than in the context A2PC (II). The presence of only two H- bonds in the 2PG base pair vs. the three H- bonds in the CG base pair [19] as well as electrostatic ... and 2P-contain- ing DNA in the presence of AdoMet causes the inhibition of methylation. One can suggest that the potency of 2-pyrimidinone as an in...

Ngày tải lên: 07/03/2014, 15:20

... meaning within any space depends on the rest of the state of the space, which furthermore depends on what previous processing has occurred to affect the state of that space. 2.2 Summary of the Processing ... representation of the currently included grammar, a brief dis- cussion of the structure of the grammar and the role of the grammar in the...

Ngày tải lên: 08/03/2014, 18:20

... phonemes), so that time to process the whole will equal the sum of processing times for each part. Since the probability of the whole can be expressed as the product of the probabilities of the ... to- gether (e.g., Bengio et al., 2003; Mnih and Hin- ton, 2007). Usually, these representations are learned together with the rest of the model, but here we used a m...

Ngày tải lên: 08/03/2014, 21:20

... progenitors triggers the onset of neurogenic divisions and consequently the production of neurons. The increase in the level of Mnb ⁄ Dyrk1A expression in DS may produce the precocious onset of neurogenic ... phosphorylation of p53, which led to the induction of p21CIP1. There are also indications that MNB ⁄ DYRK1A is involved in the mitosis of non-neural cell...

Ngày tải lên: 22/03/2014, 16:21

... results, and the results of others, highlight the pleiotropic effects that TSA administration has on chromatin structure and on gene expression. Materials and methods DNA and plasmids Construction of ... with transcriptional activation and chromatin opening through inhibition of the deacetylation of histones. However, our results and those of others show that...

Ngày tải lên: 19/02/2014, 12:20

... func- tional similarity. It has been demonstrated that anthers are the major sites of high concentrations of free auxin that retard the development of neighboring floral organs to synchronize flower ... regulated at the post-transcriptional level as well by microRNAs, which adds another layer of regulation to the auxin signal transduction pathway. The auxin signal trans- duc...

Ngày tải lên: 07/03/2014, 01:20

... methylation of the cytosines of CpG islands in the promoter or the first exon has been shown to affect the rate of transcription [33], and ever since the clear demonstration of a causal relationship ... in the pathogenic conditions associated with increased expression of many SAF target genes, due to the combination of inflammation-responsive expression of SAF-3 a...

Ngày tải lên: 07/03/2014, 02:20

... that there are also reports of dual- targeted proteins to chloroplasts and the nucleus [7], to chloroplasts and the peroxisome [8,9], and, in Chlamydomonas reinhardtii, to chloro- plasts and the ... In the case of aminoacyl tRNA synthetases, Glu aminoacyl-tRNA synthetase was processed at the same site in both mitochondria and chloroplasts but for Met and Phe aminoa...

Ngày tải lên: 07/03/2014, 03:20