Báo cáo khoa học: ABCG transporters and disease pdf

... serum urate levels measured and genotyping performed either ABCD ABCB ABCC(I) ABCC(II) ABCG ABCA ABCE ABCF ABCG2 ABCG1 ABCG4 ABCG5 ABCG8 Human ABC family members Human ABCGs Disease phenotype Gout, ... sitoster- olemia [10]. ABCG transporters and disease Members of the ABCG family are known to play a role in lipid transport across membranes. Loss-of-function mutations in...

Ngày tải lên: 22/03/2014, 15:21

... segments V and VI and the region, termed Xa, comprising the cytoplasmic loop between TMS X and XI and part of TMS XI. Studies of the citrate ⁄ lactate and malate ⁄ lactate exchangers, CitP and MleP, ... N- and C-terminal halves and vice versa within the OPA family, the AAT family, the ST3 families and the DAACS1 family. In case of the AAT and DAACS1 families, the percentag...

Ngày tải lên: 07/03/2014, 17:20

... 6-, and 12 week-old wild- type and R6/1 transgenic HD mice (n ¼ 6 per age and genotype). Three gene-specific primers and M-MLV reverse transcriptase (Promega) were used to generate first-strand cDNA ... Huntington’s disease chromosomes. Cell 72, 971–983. 3. Trottier, Y., Biancalana, V. & Mandel, J.L. (1994) Instability of CAG repeats in Huntington’s disease: relation to paren tal...

Ngày tải lên: 16/03/2014, 18:20

... Huntington’s disease. Nature 306, 234–238. 5 Huntington’s Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. ... diagnosis and prevention of Alzheimer’s disease. Curr Neurol Neurosci Rep 4, 374–380. 119 Luchsinger JA & Mayeux R (2004) Dietary factors and Alzheimer’s dise...

Ngày tải lên: 16/03/2014, 19:20

... time courses and effects of unlabeled ligands and low pH on the dissociation rates of [ 125 I]TC-PCSK9 (A) and [ 125 I]TC-PCSK9-D374Y (B) from HepG2 cells. Binding to equilibrium and removal of ... HepG2 cells (70 000, 140 000 and 280 000) were seeded in 12-well plates and incubated either for 48 h in complete growth medium or for 24 h in com- plete growth medium, and then for 2...

Ngày tải lên: 14/02/2014, 14:20

... PcrH and IpgC are shown in yellow, green and magenta, respec- tively. The peptides located within the concave regions of PcrH and IpgC, corresponding to sections of the N-termini of PopD and IpaB, ... levels (i.e. 38% for Pseudomonas PopD and Yersinia YopD; 29% for Shi- gella IpaC and Salmonella SipC). Indeed, sections of IpaC and SipC (as well as YopD and PopD) are inter- cha...

Ngày tải lên: 14/02/2014, 22:20

... t-bet, stat6 and foxp3 were also determined and found to be very simi- lar to their human homologues. Both the human and zebrafish T-bet and Foxp3 genes contained the same number of exons and introns. ... been seen within a wide variety of tissues and cells in the Ginbuna crucian carp [27] and, in mammals, in the lung tissue of mouse and spleen and thymus of human and mouse...

Ngày tải lên: 16/02/2014, 09:20

... family, and is also called GSTS1 [17]. On the other hand, L-PGDS has been purified from rat brain [18], and is expressed in brain, heart, and male genital organs, as well as in adipocytes and omen- tal ... liver and WAT. Paraffin sections of liver and WAT from WT and TG mice (S55) were stained with antibody against human H-PGDS. Bars: 100 lm. (D) PGDS activity in liver of WT and...

Ngày tải lên: 16/02/2014, 09:20

... and ubiquitin C-terminal hydrolase (specific markers for neural and neuroendocrine tissues) were found in rat long bones at embryonic day 15, in the diaphyseal and metaphyseal perichondrium, and ... adrenergic and cholinergic in nature, and originate from paravertebral sympathetic ganglia [16]. Experimental nerve deletion and immunohisto- chemistry analysis have shown that both m...

Ngày tải lên: 18/02/2014, 04:20

... NADPH and MSR 1.12 ± 0.04 With NADPH and CPR 0.09 ± 0.02 With NADPH and nNOSred 0.18 ± 0.02 MeCbl Without MSR or NADPH 0.06 ± 0.01 With MSR 1.23 ± 0.15 With FMN domain 1.20 ± 0.10 With NADPH and ... enzymes and T4 DNA ligase were from New England Biolabs (Hitchin, UK). Pfu Turbo DNA polymerase and XL1-blue competent cells were purchased from Stratagene (La Jolla, CA, USA). CH 3 -...

Ngày tải lên: 18/02/2014, 08:20