Báo cáo khoa học: Vesicular traffic in cell navigation pptx

... to enhance integrin and EGFR trafficking and to result in constitutive activation of EGFR ⁄ integrin signaling [15]. Therefore, VAMP3 and VAMP7-dependent traf- ficking may interact in integrin and ... SNAREs in migrating and invading cells both in vitro and in vivo during development [11]. Indeed, VAMP3 morpholinos lead to a defect in blastopore closure in Xenopus [11]. The main c...

Ngày tải lên: 22/03/2014, 15:21

... and detail the problems in apply- ing existing approaches to reference generation to open domains in §2. We then present our approach in §3, contrasting it with existing approaches. We extend ... 1, as long as only one dog is in a bin, the reference the dog in the bin succeeds in uniquely referencing both the dog and the bin. If n distractors of e ref contain a prep o relation wit...

Ngày tải lên: 17/03/2014, 06:20

... Stb1 was originally identified as an interacting protein of Sin3 in two-hybrid assays (Stb1 for Sin three binding) [34]. STB1 transcription was shown to be cell- cycle regulated and peaks in late G 1 phase ... Sin3 and or Rpd3, rather than by regulating Sin3 ⁄ Rpd3 directly. A good candidate for a factor regulating Sin3 ⁄ Rpd3 binding is Stb1, because it binds to both Swi6 and Sin3 [20,21...

Ngày tải lên: 23/03/2014, 05:22

... for Cube Pruning running in linear time in the beam size. Empirically, we show a gain in running time of a standard machine translation system, at a small loss in accuracy. 1 Introduction Since its ... 2009), parsing (Huang and Chiang, 2005), sentence alignment (Riesa and Marcu, 2010), and in general in all systems combin- ing inexact beam decoding with dynamic program- ming under...

Ngày tải lên: 23/03/2014, 14:20

... and was instrumental in gaining new insight into mitochondrial Ca 2+ handling, i.e. the topic of this review [13]. In the chimeric cDNA, an aequorin moiety including an HA1 tag was fused in frame ... the cell [47]. In contrast, in BHK cells inhibition of mitochondrial Ca 2+ uptake resulted in reduction of ER Ca 2+ release [48], indicating that in this case mitochondria play a...

Ngày tải lên: 30/03/2014, 20:20

... Speakers have the freedom of selecting the outgoing point for a sen- tence. Once they have selected it, the remaining con- stituents are arranged in the MF, mainly according to their grammatical properties. This ... they use are akin to those which play a role in determining German word order. We use their approach as a non-trivial baseline in our study. Ringger et al. (2004) aim at reg...

Ngày tải lên: 31/03/2014, 01:20

... by various cell signaling cascades. The insights gained in such studies support the idea that miRNAs are involved in the highly complex network of cell signaling pathways. In this minireview, ... reported to be induced by the MAPK signaling pathway. In the human B -cell line Ramos, miR-155 is induced by signaling by the B -cell receptor through the ERK and c-Jun N-terminal kinas...

Ngày tải lên: 14/02/2014, 19:20

... Schiffmann SN (2002) ‘New’ functions for ‘old’ proteins: The role of the calcium- binding proteins calbindin D-28k, calretinin and parval- bumin, in cerebellar physiology. Studies with knockout mice. ... implicated Ca 2+ signaling through calcineurin (CaN) [13] and calmodulin kinase [14] to play an important role. In addition, a recent study indicates an involvement of Ca 2+ signaling in...

Ngày tải lên: 19/02/2014, 07:20

... isoalloxazine ring (Fig. 5B, broken line, number 3). Phe in place of Trp66 r esulted in a protein with noncovalently bound FAD, again showing no enzyme activity, and isolation of the flavin cofactor ... in channelling the c-N-methyl- aminobutyrate generated from nicotine into the cell meta- bolism p roceeds b y its oxidative demethylation. Keywords: Arthrobacter nicotinovorans; c-N-met...

Ngày tải lên: 19/02/2014, 16:20

... Location of insertion sites in conserved regions. Location of insertions in N-terminal AAA + domain (domain I, shown in A), central domain (domain II, B) and C-terminal collar domain (domain III, ... conserved arginine residues to alanines in the budding yeast Rfc2, Rfc3 and Rfc4 proteins (such that the resulting RFC complex carried nine arginine-to- alanine substitutions) abolished D...

Ngày tải lên: 07/03/2014, 02:20