... sufficiently large corpora and sufficiently cheap computation have become available. Three recent papers in this area are Church and Hanks (1990), Hindle (1990), and Smadja and McKeown (1990). The ... Nonetheless, two obvious barriers still stand on the path to a fully automated SF dictionary: a deci- sion algorithm that can handle random error, and techniques for detecting...
Ngày tải lên: 20/02/2014, 21:20
... loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK Alamdar Hussain 1,2, *, Liang Yu 1,3, *, Rani Faryal 1,2 , Dara K. Mohammad 1 , Abdalla J. Mohamed 1,4 and C. I. Edvard ... metazoans [1] and com- prise five members in mammals: Bruton’s tyrosine kinase (BTK), inducible T-cell kinase (ITK), TEC, BMX [also known as epithelial and endothelial tyro- s...
Ngày tải lên: 14/02/2014, 18:20
Tài liệu Báo cáo khoa học: a-enolase: a promising therapeutic and diagnostic tumor target ppt
... 917–924. 133 Fernandez Madrid F (2005) Autoantibodies in breast cancer sera: candidate biomarkers and reporters of tumorigenesis. Cancer Lett 230, 187–198. a-enolase in tumor diagnosis and therapy ... therapeutic and diagnostic tumor target Michela Capello, Sammy Ferri-Borgogno, Paola Cappello and Francesco Novelli Department of Medicine and Experimental Oncology, Center for Experim...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Báo cáo khoa học: Paradoxical interactions between modifiers and elastase-2 Patricia Schenker and Antonio Baici docx
... poly- disperse, and the chondroitin sulfates exist as co-poly- mers of the 4- and 6-sulfate isomers (Ch4S, Ch6S) with various compositions and mean molecular masses that depend on animal species and tissue. ... of the 4 and 6 isomers within the same chain, and also contain sulfate-free sequences. Ch4S from bovine trachea contained 69% 4-sulfate and 25% 6-sulfate; Ch6S contained...
Ngày tải lên: 16/02/2014, 14:20
Tài liệu Báo cáo khoa học: How disorder influences order and vice versa – mutual effects in fusion proteins containing an intrinsically disordered and a globular protein docx
... con- tent of unordered stretches (50–59%) and a low con- tent in a-helices and b-strands (2–3% and 22–29%, respectively), whereas GFP is rich in b-strands (46%) and exhibits a low content in unordered ... the content of a-helices, b-strands, b-turns and unordered regions of the individual intrinsically unstructured proteins and GFP moieties. Analytical gel filtration and calculat...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: The heat shock factor family and adaptation to proteotoxic stress pdf
... develop- mental processes such as gametogenesis and neuro- genesis, in the maintenance of sensory and ciliated tissues, and in immune responses [12–14]. HSF1- and HSF3-mediated mechanisms of cellular ... HSF1 and HSF2 in female [53,74] and male [71,75– 77] germ cells. Neuronal differentiation and migration were affected in the HSF2-null cerebral cortex [78]. Furthermore, the d...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf
... xenotoxins. At the blood–brain barrier, and in placental trophoblasts, testis and bone marrow, it provides protection of vital body parts and, in the gut, liver and kidney, Pgp helps to eliminate ... [15–18]. On the other hand, MRP1 is present in virtually all human tissues and in most human tumor cell lines and tumor samples [4]. Using mice genetically deficient in both the mdr1a...
Ngày tải lên: 18/02/2014, 13:20
Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
... supplied with the enzyme, and contained Aba, Abb and Abcat 40 nm each, and the start and stop primers Abstart and Abstop at 600 nm each, and 200 lm each of dATP, dCTP, dGTP and dTTP. The product ... Ab(1–40) and Ab(M1–40) are at least 97% pure. In the lanes containing Ab(1–42) and Ab(M1– 42), there were prominent bands at approximately 4 kDa and faint bands at approximatel...
Ngày tải lên: 18/02/2014, 13:20
Tài liệu Báo cáo khoa học: DNA methylation-mediated nucleosome dynamics and oncogenic Ras signaling pptx
... dynamics and oncogenic Ras signaling Insights from FAS, FAS ligand and RASSF1A Samir K. Patra 1, * and Moshe Szyf 2 1 Cancer Epigenetics Research, Kalyani, India 2 Department of Pharmacology and Therapeutics, ... by H-Ras and K-Ras signaling that is facilitated by lipid rafts, on the one hand [98,144] (Fig. 3A), and radia- tion ⁄ chemotherapy can cause demethylation-induced FAS ex...
Ngày tải lên: 18/02/2014, 14:20
Tài liệu Báo cáo khoa học: Calcium-binding to lens bB2- and bA3-crystallins suggests that all b-crystallins are calcium-binding proteins pptx
... proteins and induce luminescence peaks at 492 nm and 547 nm via energy transfer from Trp and Tyr residues [32]. Terbium binds to bB2- and bA3-crystallins and induces luminescence peaks at 492 and ... acidic (bA1 ⁄ A3, bA2 and bA4) and three basic b-crystallins (bB1, bB2, and bB3). b-Crystallins have high sequence similarity and identity [4]. Acidic b-crystallins have both...
Ngày tải lên: 18/02/2014, 16:20