... into the TAG pool only in the presence of oleate [18]. The above results raise two main questions: (a) whatis the cause of TAG synthesis inhibition, and (b) whatis the exact nature of the events ... incubationperiods. Interestingly, the interruption of TAG synthe-sis preceded the appearance of toxic effects, supporting the notion that it constitutes the initiating event in the process of lipotoxicity.Stearate ... to identify the keyevent(s) responsible for these differences, we examined the main steps involved, following the uptake of satu-rated and unsaturated FFAs into the cells. After theirinternalization,...