Báo cáo khoa học: "The key role of semantics in the development of large-scale grammars of natural language" pdf

Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx

... ele-ments, very little is known about their role in DIDOactivity. The combination of domains (domain shufﬂing)is a driving force in Eukarya in the acquisition of KeywordsCGBP; DATF1; DIDO1; DIO; ... from the other bran-ches, which was indeed predicted. The other maingroup, obtained 97% of the time in 20 740 exploredtrees, contained the DIDO PHD sequences clusteredwith the PHF and the ... modiﬁcations of chromatin [9]. Little isknown, however, of the functional role of the remain-ing subclass members. In this study, the yeast protein SPP1 (alias cps40), amember of the COMPASS...

Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

... promoting an increase in proopiomelanocortin and cocaine and amphetamineregulated transcript. Taken together, these ﬁndingsprovide a compelling argument for the role for malo-nyl-CoA in regulating ... and certain amino acids [16].A linkage between fatty acid synthesis in the CNSand feeding behavior was uncovered with the ﬁndingthat systemic or intracerebroventricular administration of fatty ... cru-cial roles in the regulation of metabolism, both glob-ally and in various organ systems. Even in organismslacking a brain, such as Caenorhabditis elegans, the nervous system plays a key role in...

Báo cáo khoa học: Metabolomics, modelling and machine learning in systems biology – towards an understanding of the languages of cells potx

... development of principled explanations of such causal linkages.CodaHaving begun with a couple of quotations, and havingstressed the role of technology development in science in general and in systems ... in these pathways, and stresses the role of signal process-ing (and not merely the intermediates) in biological signalling. It is thissignal processing that lies at the heart of understanding ... thoseinvolving the nuclear transcription factor NF-jB–may encode their signals not so much in terms of changes in the concentrations of the observable signal-ling intermediates but in terms of their...

Báo cáo khoa học: Monomeric molten globule intermediate involved in the equilibrium unfolding of tetrameric duck d2-crystallin pdf

... stabilityfor crystallins is essential in maintaining lens transparency[4]. Determining the mechanism of folding and assembly of these proteins is important for understanding how they canform stable ... concentrations. The d2-crystallin in lens was recruited during evolutionfrom argininosuccinate lyase, an enzyme involved in arginine biosynthesis derived from the urea cycle. Thesetwo proteins shared ... further increased. The unfolding curveusing the ANS ﬂuorescence probe suggested a multistateprocess, consistent with the results obtained by proteinintrinsic ﬂuorescence and CD. The binding...

Báo cáo khoa học: Cellular response to unfolded proteins in the endoplasmic reticulum of plants pptx

... pivotal role of the UPR is to maintain ER home-ostasis. Therefore, the presence of mutated proteinsthat are unable to fold into their native conformation in the ER induces the UPR in an effort ... chain is brefeldin A-insensitive and isinhibited by the proteasome inhibitor clasto-lactacystinb-lactone, resulting in the accumulation of ricinA chains. These stabilized ricin A chains are partlydeglycosylated ... peptide in the 24-kDa a-zein and the 19-kDa a-zein endosperm storage proteins, respect-ively. These mutant proteins are translocated into the lumen of the ER, but remain anchored to the mem-branes...

Báo cáo khoa học: A novel retinol-binding protein in the retina of the swallowtail butterﬂy, Papilio xuthus docx

... staining of the gel indicates that the ﬂuorescing protein is one of the major components of soluble proteins in the crude extract. The surface of the ﬂuorescing protein carries negative charge in ... cellular retinal-binding protein; CRBP,cellular retinol-binding protein; IRBP, interphotoreceptorretinoid-binding protein; RBP, retinol-binding protein.Note: The nucleotide sequence reported in this ... ligand-binding protein in the ﬂy chemosensoryhair [26]). The calculated pI value of the Papilio RBP is 4.92; the protein is highly acidic. This explains the high mobility of the protein in the native...

Báo cáo khoa học: Biochemical evidence for conformational changes in the cross-talk between adenylation and peptidyl-carrier protein domains of nonribosomal peptide synthetases ppt

... by decreasing the rate of cleavagebetween the two subdomains of the A domain. Theseﬁndings were later explained with the structural modelthat the smaller subdomain AC of the A domainrotates ... important role in the productive interaction between the A domain and the PCP domain. The recently reported crystal structure of a termina-tion module from the surfactin NRPS, consisting of the domains ... for the investigation of the highly homologous protein tyrocidine synthetaseI (TycA) in its apo-form. They found that the addition of the substrates slowed down the proteolysis of the protein,...

Tài liệu Báo cáo khoa học: A genetic screen identifies mutations in the yeastWAR1 gene, linking transcription factor phosphorylation to weak-acid stress adaptation docx

... were raised in rabbitsagainst a GST-War1p fusion protein containing 294 aminoacids of the C-terminal part of War1p (amino acids 650–944) fused in- frame to the C-terminus of GST. The genefusion ... a binuclear DNA-binding zinccluster at the N-terminus, whereas the acidic activationdomain is usually present at the C-terminus. The mid-dle homology region (MHR) bridging the DNA-bind-ing ... expression of the C-terminal 294 amino acids of WAR1 fused in- frameto the C-terminus of GST. Escherichia coli strain DH5aharboring pCG1950 was grown on 37 °CtoanA600 of 0.5.Expression of the GST-War1p...

Tài liệu Báo cáo khoa học: "A HYBRID APPROACH TO REPRESENTATION IN THE JANUS NATURAL LANGUAGE PROCESSOR" pot

... defining the set of items that have ever been the actor in a flight. Their definition is solely within NIKL using the QUA link [14], which is exactly the set of fillers of a slot. While having ... complex theorem proving for expressions in inten- sional logic. 3 4. Use of the Taxonomy in Janus By domain mode/we mean the set of axioms en- coded in NIKL regarding the constants. The domain ... all of the definitions of approximately 200 items from the base vocabulary using the defini. tJons of those vocabulary items themselves in the dictionary. In this attempt, we encountered the...

Tài liệu Báo cáo khoa học: "Subgrammars, Rule Classes and Control in the Rosetta Translation System" ppt

... the result of the application of the rule of that node on the resulting S-trees of its daughters (see figure I). the donkey is eating apples -the donkey the donkey eat apples donkey R, eat ... leading to the division of all the rules of the grammars into (meaningful) rule classes, are along hor- izontal lines. These two ways of dividing grammars have several consequences. On the ... that the place of this subdivision coincides with the 'switch point'. There is another argument for making this sub- division: the first part of the control expression of the subgrammars...

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