Báo cáo Y học: Induction of chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI ) gene expression is mediated by ETS factor binding sites doc
Báo cáo Y học: Induction of chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI ) gene expression is mediated by ETS factor binding sites doc
... Induction of chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI ) gene expression is mediated by ETS factor binding sites Ramiro Salas*, Fabrice G. Petit, Carlos Pipaon, ... ()3 97 /)2 59 and )4 90 /)4 0 8), eachcarrying three putative binding sites. The subfragment )3 97 /)2 59 is not responsive to Ets- 1, w hile the )4 90 /)4 08subfragment is stimulated by Ets- 1 to a similar ... higher af®nity even in theabsence of a ccessory factors. The auto-inhibitory domain is located within exon VII and a n alternative ly spliced form of Ets- 1 t hat lacks this exon is constitutively...
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Tài liệu Báo cáo Y học: Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine docx
... neuronaltoxicity in vitro [41–43]. This may apply to myotoxicity asWisniewski & Wegiel [12] observed that leptomeningealmyocyte destruction was also preceded by Ab fibrillogen-esis. However, Davis-Salinas ... plays a crucial role ineliciting toxicity.Ab-Induced apoptotic cell death is well documented.There is increasing evidence that neurons die via apoptoticmechanisms in a range of neurodegenerative ... to elicit adose-dependent increase in toxicity in VSMC. In thepresence of Ab peptides, this toxicity is exacerbated. Thiseffect of homocysteine and Ab hasalsobeenshowninprimary cortical neurons...
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Báo cáo khoa học: Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation pot
... protein production andantibody purification teams (Division of SignalTransduction Therapy, University of Dundee), coor-dinated by Dr H. McLauchlan and J. Hastie, forgeneration and purification of ... Thesefindings indicate that when apoptosis is initiated inHeLa cells exposed to hypertonicity, activation of caspases causes the proteolysis of hDlg at YEVD747and this releases it from the cortical ... apoptosis induced by sorbitol. As shown in Fig. 8, none of these processeswas significantly affected by the mutation D747A of hDlg, indicating that its proteolysis is not sufficient forthe regulation...
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Tài liệu Báo cáo Y học: Induction of (2¢)5¢)oligoadenylate synthetase in the marine sponges Suberites domuncula and Geodia cydonium by the bacterial endotoxin lipopolysaccharide docx
... (2–5)A synthetase system is involved in defenseagainst microorganisms, very likely by inhibition of cellproliferation or induction of apoptosis.MATERIALS AND METHODSMaterialsRestriction ... concentrations of LPS (10 lgÆmL )1 ) caused a lower effect on the (2–5)Asynthesizing activity in S. domuncula.Despite the initially high (2–5)A synthesizing activity intissue of G. cydonium (aquarium ... 97%similarity with respect to amino acids and with theG. cydonium enzyme 28% identity and 48% similarity.The percent identity (similarity) t o the mammalian (mouse)(2–5)A synthetase is 19% (36%)...
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Báo cáo Y học: Regulation of glypican-1, syndecan-1 and syndecan-4 mRNAs expression by follicle-stimulating hormone, cAMP increase and calcium influx during rat Sertoli cell development pptx
... Sigma (Saint-Quentin Fallavier,France). oFSH is a generous gift of National institute of Arthritis Metabolic and Digestive Diseases. Avian Myelo-blastosis Virus (AMV) reaction Buffer 5·, oligo ... observations strongly suggest the participation of syndecans in signal transduction mechanisms while that of glypicans is still poorly understood.In the mammalian testis, Sertoli cells are epithelia ... C-termini of proteins.Syndecans and glypicans are individually expressed indistinct cell-, tissue-, and development-specific patterns[6–10]. Modifications in glypican and syndecan expression may...
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Tài liệu Báo cáo khoa học: Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker’s yeast doc
... addi-tion, highly specific protein degradation occurs viaproteasome -mediated proteolysis of ubiquitin-taggedproteins [41]. Ubiquitination of proteins is catalysed by three enzymes: ubiquitin-activating ... which the change in flux through anindividual enzyme is regulated by a change in enzymeKeywordsfermentative capacity; glycolysis; regulationanalysis; Saccharomyces cerevisiae;systems biologyCorrespondenceB. ... glucose-excess conditions in the presence of nitrogen is anexample of this form of regulation.A summary of all regulation is given in Table 3. Thisshows visually that 5 of 10 enzymes exhibit a similar regu-lation...
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Báo cáo y học: " Induction and effector phase of allergic lung inflammation is independent of CCL21/CCL19 and LT-beta
... Medicine, La Jolla, CA, USA 3. Department of Dermatology, School of Medicine, University of California, Davis, CA, USA 4. Division of Biomedical Sciences, University of California, Riverside, ... parenchyma might be sufficient to trigger the cascade of cytokines and chemokines necessary for tissue eosinophilia without involvement of draining lymphoid tissues. We studied the induction of lung ... airway responsiveness was assessed in i. p. immunized mice (A) and recipients of antigen specific CD4 T cell transfer (B). Airway sensitivity of C57BL/6J mice (circles), LTβ-KO (squares) and...
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Báo cáo y học: " Implementation of a new emergency medical communication centre organization in Finland an evaluation, with performance indicators"
... and action should result in similardistribution of priority classes in different EMCCUnderestimation of priorityLife-threatening situations not detected by EMDand thus classified with a lower ... EMCC organization reform in Finland did notTable 1 Identified performance indicatorsPerformanceindicatorsDescriptionPriority distribution General indicator of EMCC quality. An emergencycall ... number of highpriority calls increased. There was a trend, but no statistically significant increase in the emergency medicaldispatchers’ ability to detect patients with life-threatening conditions...
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Báo cáo y học: "Management of chest pain: exploring the views and experiences of chiropractors and medical practitioners in a focus group interview"
... institution offering a training program coor-dinated by a medical physician. However, this is in itsinfancy and much needs to be worked out. This does indi-cate a growing level of interest in this kind ... uncertainty, complexity,and discriminant variability are characteristic of chestpain assessment and diagnostic tests, that the inherentlyhigh risk of chest pain determines the order of differentialworkup ... discuss the feasibility of conducting or coordinating a multidisciplinary researcheffort along this line of inquiry. The convenience-sample of five focus group participants includedtwo chiropractors,...
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Báo cáo y học: "Use of chinese and western over-the-counter medications in Hong Kong"
... pharmacists, tertiary education is not a prerequi-site for retailing Chinese medicine OTC [9]. Historically,Chinese medicine retailers worked alongside with Chi-nese medicine practitioners ... services and OTCmedication usersVisited Chinesemedicinepractitioners only ( %) Used Chinese OTCmedications only( %) Consulted Chinese medicinepractitioners and used Chinese OTCmedications ... community pharmacists consider edu-cation activities as one of their main duties) [7]. Appropriatetraining may help community pharmacists make their pri-mary care practice more evidence-based...
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