Báo cáo khoa học: Phosphorylation of Hrs downstream of the epidermal growth factor receptor docx
Báo cáo khoa học: Phosphorylation of Hrs downstream of the epidermal growth factor receptor docx
... role in the trafficking of growth factor/ receptor complexes through early endosomes. Stimulation of cells with epidermal growth factor (EGF) rapidly leads to phosphorylation of Hrs, raising the question ... Phosphorylation of Hrs downstream of the epidermal growth factor receptor Kristi G. Bache1, Camilla Raiborg1, Anja Mehlum1, Inger Helene Madshus2and Harald Stenmark11Department of ... 3–4), the phosphorylation was much weakerthan that detected at 37 °C, supporting the idea thatendocytosis of the receptor/ ligand complex is important for the phosphorylation of Hrs. Nevertheless,...
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Báo cáo khoa học: Phosphorylation mechanism and structure of serine-arginine protein kinases pot
... of some precursormRNAs [34], other studies have shown that the phos-phoryl content of the RS domain is important. Forexample, phosphorylation of SRSF1 controls the alter-native splicing of ... to the nuclear entry of SR pro-teins. It has been shown that phosphorylation of the RS domain leads to enhanced interactions with the nuclear import receptor, transportin SR, and entry of the ... group of kinases, changesin the sequence of the MAPK insert and positions of helices aG and aH result in the loss of the deep sub-strate docking groove observed in SRPK1. In additionto the MAPK...
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Tài liệu Báo cáo khoa học: Phosphorylation of hormone-sensitive lipase by protein kinase A in vitro promotes an increase in its hydrophobic surface area ppt
... studies devoted to the elucidation of the phosphorylation sites in HSL and the regulation of itstranslocation, few studies have addressed the effects of PKA phosphorylation on the HSL molecule ... in the presence of the given concentrations of the hydro-phobic probe bis-ANS, using TO as substrate. The activity of phos-phorylated HSL in the TO assay was normalized to the activities of nonphosphorylated ... in the effect of bis-ANSupon PKA phosphorylation of HSL. The interaction of HSL with bis-ANSwas found to have a Kd of 1 lm in binding assays. Upon PKA phosphory-lation, the interactions of...
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Tài liệu Báo cáo khoa học: Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases pptx
... tubeassays. The accumulation of C-YES in the precipitatescorrelated with the appearance of kinase activity inthose samples. The level of depletion of kinase activitymirrored the level of depletion of ... strategies for the treatment of cancer. The activity of the CDK4 ⁄ cyclin D holoenzyme isregulated by multiple mechanisms, the most important of which is the association of CDK4 with the D-typecyclin ... con-served and there is an equivalent residue to the Y17 site of CDK4 in each of these kinases. To allow the study of CDK4 Y17 phosphorylation, a phosphospecific anti-body to the Y17 site was...
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Báo cáo khoa học: Phosphorylation-dependent binding of human transcription factor MOK2 to lamin A⁄C pot
... which is the mostrecently identified member of the JIP group of scaffoldproteins [11]. To determine which region of hsMOK2interacts with JLP, we co-transformed the yeast strainL40 with the library ... either the nonfinger acidic domain(pLex–NH2) or the finger domain (pLex–finger) of hsMOK2, and performed b-galactosidase assays. The JLP 1–141 domain interacted only with the fingerdomain of ... Identification of JLP as a partner of hsMOK2 using the yeast two-hybrid screen and identification of the hsMOK2 interac-tion domain. (A) Constructs expressing full-length or the indicateddomains of hsMOK2...
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Báo cáo khoa học: Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily pot
... 1B). The partial phosphorylation of Grx4p still observedin the case of the two mutants (corresponding to30–40% of that of the wild-type) could be explainedeither by the intervention of another ... elongation. We have then examined the effects of Ser258 phosphorylation of Bud32p on the transcriptional activity of the EKC ⁄ KEOPS com-plex by analyzing the activation rate of the galactose-inducible ... indirectly, the activity of the enzyme. To evaluate the contribution of either Ser134or Ser133 phosphorylation to the biological compe-tence of Grx4p in yeast cells, we created a series of unphosphorylatable...
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Báo cáo khoa học: Phosphorylation of NF-jB proteins by cyclic GMP-dependent kinase A noncanonical pathway to NF-jB activation potx
... Substrate phosphorylation of p49 or p50depends on the presence of PKG and isenhanced by the addition of cGMP, whereascGMP in the absence of the kinase does notmediate measurable incorporation of ... induction of the fastermigrating NF-jB band. Note that the resting levels of NF-jBbindingare relatively high in O3 cells, because the clone depends on the pre-sence of interleukin-2 in the growth ... and activate the transcription factor CREB, the connection of PKG to gene expression is incompletelyunderstood. Recently, the localization of the PKG form I in the cytosol and the nucleus was...
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Báo cáo khoa học: Phosphorylation modulates the local conformation and self-aggregation ability of a peptide from the fourth tau microtubule-binding repeat pdf
... modulate the process of aggregation.Results Phosphorylation of Ser356-induced conforma-tional change in peptide R4To investigate the effect of phosphorylation at Ser356on the native structure of ... site.Identification of the hydrogen-bonding partnersdepends on detailed investigations into the pH depen-dence of their NMR parameters over the pH range3–8. Obviously, the pH titration curve of the amideproton ... pKa2. The pKavalue is deter-mined from a fit of the phosphorus chemical shifts of the without ionic, monoionic and diionic forms of the phosphate group as a function of pH [33,34]. The phosphorus...
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Báo cáo khoa học: Photosynthetic acclimation: Structural reorganisation of light harvesting antenna – role of redox-dependent phosphorylation of major and minor chlorophyll a/b binding proteins pot
... structure of the higher plant PSI supercomplex provided an insightinto the organization of the PSI core and the assembly of its associated LHCI together with the bound pig-ments and cofactors ... cofac-tors of the components of the photosynthetic electrontransport chain). However, the most rapidly changingenvironmental factor is the quantity and spectral qual-ity of incident light, often ... both via PQ and the cyt6f complex, andthrough the thioredoxin ⁄ ferrodoxin system in the stroma of the chloroplasts [44]. Rochaix has recentlyreported that mutations of either of the two conservedcysteine...
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Báo cáo khoa học: Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization pptx
... phosphorylation. Effect of RS motif phosphorylation onoligomerization of the N proteinTo better understand the effect of RS motif phosphor-ylation on the biological function of the N protein, weFig. 3. The translation ... that of the full-length N protein (data not shown). Taken together,these data suggest that the RS-rich region of the SARS-CoV N protein is possibly phosphorylated by SRPK1. Phosphorylation of ... copies of the N protein, respectively. (C) The RNA binding efficiency of N protein is represented as a percentage of bound RNA (i.e. the percentage of bound RNA = 100%)percentage of free probe). The...
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