... Pro, Val or Lys, c-carboxylation of Glu, glycosylation of Ser or Thr, bromination of Trp, sulfation of Tyr, cyclization of N-terminal Gln, and epimerization of several different residues. It ... 1977effect of the d-Phe on structure, was also studied. Theunusual structure of conomarphin further demon-strates the high diversity of conotoxins.Results Purification and primary sequence of conomarphinAs ... structure of conomarphinwas similar to those of other conotoxin cDNAs. ThecDNA-encoded precursor of conomarphin consisted of a conserved M-superfamily signal peptide of 25 resi-dues, a proregion of...