Báo cáo khoa học: Deadenylation of interferon-b mRNA is mediated by both the AU-rich element in the 3¢-untranslated region and an instability sequence in the coding region pot

... Deadenylation of interferon-b mRNA is mediated by both the AU-rich element in the 3¢-untranslated region and an instability sequence in the coding region Muriel Paste ´ , Georges Huez and ... However, the deadenylation and degradation of IFN-b mRNA is under the control of two independent elements, one of which is located in...

Ngày tải lên: 17/03/2014, 10:20

... approaching the reversal potential of the ANT [23]. At 0 mV, during which both the ANT and the F 0 F 1 -ATP synthase operate in reverse mode, the increase in ADP–ATP exchange rate mediated by the ANT ... an insignificant increase (1.38–1.7%) in the ADP–ATP exchange rate mediated by the ANT in maximally polarized (forward mode of both ANT and ATPase...

Ngày tải lên: 14/02/2014, 19:20

... Chemistry and Bioengineering, Changsha University of Science and Technology, Hunan, China 3 College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan, ... promote the expres- sion of SR-BI, resulting from the binding to putative KLF4 binding element on the promoter of SR-BI. All results indicate a potential function...

Ngày tải lên: 18/02/2014, 04:20

... that induction of apt1 and and induc- tion of gpx1 depend solely on the Pap1 and Atf1 tran- scription factors, respectively, and that induction of ctt1 is dependent on both Pap1 and Atf1 in Sc. ... ubiquinone biosynthesis occurs in mitochondria in yeasts. In summary, our results indicate that coq7 is required for ubiquinone biosynthesis and the coq7 mutant i...

Ngày tải lên: 18/02/2014, 14:20

... or cofactor. In detail, the N-terminal module is the homocysteine (Hcy)-binding domain; the second domain binds 5-methyltetrahydrofolate, the third domain binds CH 3 -Cbl; and the fourth domain ... design of inhibitors of methionine synthase. Our results indicate that the potency of the tested compounds is related to a planar region of the inhibitor that can...

Ngày tải lên: 19/02/2014, 05:20

... hydrolysis to aldehyde and quinolamine. The band disappeared on admission of oxygen into the solution. The band at 350 nm formed by LCAO, upon bleaching of the radical, suggests that the neutral ... as shown by the measured amounts of H 2 O 2 , by the initial intensity of the radical spectrum and by the bleached 500 nm band. Which of the two equilibri...

Ngày tải lên: 19/02/2014, 12:20

... chain length of the cells expressing the mutant enzymes, and sedimentation of the cells in standing cultures; (c) their enzymatic activities, both in the cell and supernatant fractions; and (d) autolysis ... proteins, but not in archaeal proteins [14]. From an analysis of proteins containing LysM domains it is clear that the number of domains and their po...

Ngày tải lên: 19/02/2014, 18:20

... characterized by swelling of organelles and cells, followed by lysis of the plasma membrane and random DNA degradation. In contrast, apoptosis is a process that is characterized by cell shrinkage, ... was suppressed by SB202190, a potent inhibitor of p38, in F9 cells. These findings indicated that the activation of p38 is an essential step for apoptosis in...

Ngày tải lên: 21/02/2014, 03:20

... enthusiastic assistance with statistical analyses. This work was sup- ported by the Endocore Research Trust, the Maurice and Phyllis Paykel Trust, and the New Zealand Lot- tery Grants Board, and by Programme ... caspase-3 activation by 30%; as did combined SB203580 and JNK inhibitor I, by about 70%; and the combination of SB203580, the JNK inhibitor I and a ca...

Ngày tải lên: 07/03/2014, 12:20

... Because these inhibitors decrease both hyperglycemia and hyperinsulinemia, they reduce insulin resistance and stress on the beta-cells of the pancreas, thus preventing further insulin-dependent disorders ... for use in kinetic and inhibi- tion analysis as well as future use in structural studies. Kinetic analysis confirmed the enzyme activity of the recombinant protein,...

Ngày tải lên: 07/03/2014, 12:20