Báo cáo khoa học: "Formal aspects and parsing issues of dependency theory Vincenzo Lombardo and Leonardo Lesmo" potx

Báo cáo khoa học: Limited mutagenesis increases the stability of human carboxypeptidase U (TAFIa) and demonstrates the importance of CPU stability over proCPU concentration in down-regulating fibrinolysis doc

Báo cáo khoa học: Limited mutagenesis increases the stability of human carboxypeptidase U (TAFIa) and demonstrates the importance of CPU stability over proCPU concentration in down-regulating fibrinolysis doc

... with (i) a mixture of A115 and F23, (ii) a mixture of A115 and F23, (iii) Y353 and (iv) A115. Table 5. Kinetic and stability parameters for purified WT and mutant CPUs. The T1 ⁄ 2 of activity at 37 ... instability of CPU is likely to be of major importance for the in vivo down-regulation of its activity, but the under- lying structural mechanisms of this fast and spon...

Ngày tải lên: 07/03/2014, 12:20

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Báo cáo khoa học: Microcin J25 induces the opening of the mitochondrial transition pore and cytochrome c release through superoxide generation doc

Báo cáo khoa học: Microcin J25 induces the opening of the mitochondrial transition pore and cytochrome c release through superoxide generation doc

... effect of MccJ25, which strengthens the hypothesis that MccJ25 gener- ates ROS, regardless of the presence of calcium. Discussion Understanding the mechanisms of action of some types of proteins and ... uptake of calcium through the uniport of calcium. On the other hand, KCN and antimycin A, both inhibitors of electron transport, also inhibited the swelling induced by Mc...

Ngày tải lên: 16/03/2014, 06:20

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Báo cáo khoa học: Principles behind the multifarious control of signal transduction ERK phosphorylation and kinase/phosphatase control potx

Báo cáo khoa học: Principles behind the multifarious control of signal transduction ERK phosphorylation and kinase/phosphatase control potx

... dependence of the activity of the third kinase, we varied the V max of the second kinase reaction and recalculated the concentration of the active form of the third kinase as a function of time. ... the linear range of the method. The standard error of the mean was 4.6% of the measured value. Acknowledgements We thank Boris N. Kholodenko for intensive discus- sions, and...

Ngày tải lên: 16/03/2014, 18:20

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Tài liệu Báo cáo khoa học: Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression ppt

Tài liệu Báo cáo khoa học: Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression ppt

... in the levels of HSF1 and MTA1 (a component of the NuRD complex containing HDAC1 and HDAC2) proteins and to binding of HSF1 to MTA1 [78]. The complex is recruited to the promoters of estrogen-responsive genes ... consisting of multiple inverted repeats of the pentanucleotide sequence nGAAn. A single HSF of yeast can bind to heat shock elements that differ in the configurati...

Ngày tải lên: 18/02/2014, 04:20

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Tài liệu Báo cáo khoa học: MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor pdf

Tài liệu Báo cáo khoa học: MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor pdf

... because of its higher fold of upregula- tion in gastric adenocarcinoma tissues. Although the extent of upregulation of miR-23a in the four pairs of gastric tissues showed great variance because of the ... the regulatory effects of miR-23a on the expression of IL6R by RT-PCR and western blot, and found an inverse correlation between miR-23a and IL6R expression at both the...

Ngày tải lên: 18/02/2014, 04:20

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Tài liệu Báo cáo khoa học: The miRNA-192 ⁄194 cluster regulates the Period gene family and the circadian clock doc

Tài liệu Báo cáo khoa học: The miRNA-192 ⁄194 cluster regulates the Period gene family and the circadian clock doc

... Examination of BMAL1 mRNA oscillation over a time course of 64 h revealed A B C D * * * Fig. 2. Validation of the effect of miR-192 ⁄ 4 on the Per 3¢UTRs. (A–C) Verification of the effect of miR-192 ... repre- sented as the standardized mean ± standard error of the mean (SEM). HCT116 cells express low levels of miR-192 ⁄ 194, whereas LOVO and HT29 cells express high levels o...

Ngày tải lên: 18/02/2014, 06:20

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Tài liệu Báo cáo khoa học: Mouse recombinant protein C variants with enhanced membrane affinity and hyper-anticoagulant activity in mouse plasma pptx

Tài liệu Báo cáo khoa học: Mouse recombinant protein C variants with enhanced membrane affinity and hyper-anticoagulant activity in mouse plasma pptx

... All other reagents and buffer components were commercially available and of highest the purity. Mutagenesis, construction and stable expression of recombinant mouse protein C and variants Mutagenesis ... Kirchhofer D (1996) The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 380, 41–46. 37 Small DM (1967) Phase equilibria a...

Ngày tải lên: 18/02/2014, 06:20

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Tài liệu Báo cáo khoa học: Nuclear receptors in the mosquito Aedes aegypti Annotation, hormonal regulation and expression profiling ppt

Tài liệu Báo cáo khoa học: Nuclear receptors in the mosquito Aedes aegypti Annotation, hormonal regulation and expression profiling ppt

... established a lack of fluctuation in the protein levels of AaEcR and AaUSP isoforms during vitello- genesis [13], suggest a lack of significant transcriptional and translational regulation of the two components that ... isoforms, each with a distinctive N-terminal A ⁄ B domain [36]. AaE75B cannot bind DNA due to the lack of one of its zinc fingers. All three isoforms present a si...

Ngày tải lên: 18/02/2014, 13:20

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Tài liệu Báo cáo khoa học: Role for nectin-1 in herpes simplex virus 1 entry and spread in human retinal pigment epithelial cells docx

Tài liệu Báo cáo khoa học: Role for nectin-1 in herpes simplex virus 1 entry and spread in human retinal pigment epithelial cells docx

... Ophthalmology and Visual Sciences, College of Medicine, University of Illinois, Chicago, IL, USA 2 Department of Pathology, College of Medicine, University of Illinois, Chicago, IL, USA 3 Department of ... mediates entry of HSV-1 into human T lymphocytes and trabecular mesh- work cells, and is expressed in many fetal and adult human tissues, including the lung, liver, ki...

Ngày tải lên: 18/02/2014, 14:20

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Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients pdf

Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients pdf

... joints of the hands and feet. The inflammatory process is characterized by infiltration of inflammatory cells into the joints, leading to proliferation of synoviocytes and destruction of cartilage and ... against the development of RA [61]. The gene copy number variations of CCL3-like 1 (CCL3L1), a nonallelic isoform of CCL3 encoded by different genes and a potent ligand fo...

Ngày tải lên: 18/02/2014, 18:20

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