... the conformationaround the active site of ApeSOD is independent of the presence of a metal cofactor.Figure 3D shows the superimposition of the active site structures of apo, Mn-bound and Fe-bound ... (Fig. 3A). Three of the ligands,OD2 of Asp165, NE2 of His79 and NE2 of His169,formed an equatorial plane. The other protein ligand,NE2 of His31, bound to the metal, in the company of a water oxygen, ... structure of ApeSOD. In particular, we focuson the coordination of the metal cofactor in the active site as well as the changes it experiences in response todifferent metal cofactors. Finally, by...