Báo cáo khoa học: Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor–factor VIIa–factor Xa–tissue factor pathway inhibitor pptx

... proliferation and collagen synthesis involve the b-catenin signaling pathway. Inhibition of b-catenin signaling pathway using quercetin blocked the a-defensin-induced increase in collagen release ... signaling pathway. We then studied the role of the b-catenin signaling pathway in a-defensin- induced increases in the proliferation and collagen syn- thesis of lung fib...

Ngày tải lên: 18/02/2014, 06:20

... residues in the flanking helices and loop are conserved compared with EF-hand III in CaM and the STIM1 EF-hand, such as position 8 in the loop, )8, )5, )1 in the E helix and +4, +5 in the F helix, which ... proposed Ca 2+ - coordinating ligands in italic) was inserted into the host pro- tein CD2 domain 1 between residues S52 and G53 with three Gly at the N-t...

Ngày tải lên: 07/03/2014, 00:20

... to interrupted stacking, fluctuating nature of the hydro- gen bond and water organization in the vicinity of the mismatch might be the contributing factors for the increase in free energy and diminished stability ... mismatch brings about signifi- cant reduction in adjacent base stacking in PD wt compared to PD mut . On the other hand, stacking at the AC(6–7) step in...

Ngày tải lên: 07/03/2014, 21:20

... PtdIns(5)P, PtdIns(3,4)P 2 and PtdIns(3,5)P 2 with the strongest binding to PtdIns(5)P (Fig. 1). The ORD domain showed a very similar lipid binding pattern as the full- length protein. While the ... structures. At 10 min, punctate staining diminished and vacuolar staining in- creased, and finally punctate staining was almost lost with predominant vacuolar staining at 30 min. Co...

Ngày tải lên: 07/03/2014, 21:20

... bridges in the analogs with respect to their adenosine moieties. Details of the syntheses will be published elsewhere, and we present, in the Supporting information, only the key steps leading to the ... competitive inhibitors, with K i values of 2.2 lm (3) and 1.5 lm (4) for the lupin enzyme and of 2.1 lm (3) and 2.5 lm (4) for the human counter- part. These K i val...

Ngày tải lên: 16/03/2014, 04:20

... both the candi- date and the reference translations. However, the current command-line interface returns the results only in text mode and does not allow for fully ex- ploiting this linguistic information. ... divided by the cardinality of their union. The example in Table 1 shows the counts used to cal- culate O l between the reference and two candidate translat...

Ngày tải lên: 16/03/2014, 20:20

... reoxygenation but is ineffective at maintaining glutathione levels during hypoxia Glutathione is one of the main antioxidant compounds in the cell, and it is also essential for DNA synthesis and repair ... lactate and alanine. This is due to the blockade of the tricar- boxylic acid cycle induced by lack of oxygen. We examined the peaks corresponding to the glutathione carb...

Ngày tải lên: 18/02/2014, 16:20

... in each of the development and test corpora, and 120,000 words in each of the train- ing corpora. We will refer to the training corpora as TR1 and TR2, and to the test corpora as, TE1 and TE2. ... Proper Noun resulting from missing entries in the Buckwalter’s lexicon. The remaining case was a failure in the conversion process relating to the handling of bro-...

Ngày tải lên: 20/02/2014, 15:20

... luck in Nigeria and Ger- many and reflects ambition and desire in India. Some expressions involving colors share the same meaning across many languages. For in- stance, white heat or red heat (the ... tra- ditions and beliefs of a society. As shown in (Sable and Akcay, 2010) green represents danger in Malaysia, envy in Belgium, love and happiness in Japan; red is a...

Ngày tải lên: 22/02/2014, 02:20

... contamination by the other rZPGs and examined the sperm-binding activity and complex formation of these rZPGs. We also created deletion mutants of recombinant (r)ZP4 to examine whether its N-terminal region ... N-linked chains in these proteins. Native bovine ZP2 has three N-linked chains [40], but the numbers of N-linked chains in native bovine ZP3 and ZP4 have not been rep...

Ngày tải lên: 07/03/2014, 05:20