Báo cáo khoa học: Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor–factor VIIa–factor Xa–tissue factor pathway inhibitor pptx

Tài liệu Báo cáo khoa học: a-Defensins increase lung ﬁbroblast proliferation and collagen synthesis via the b-catenin signaling pathway doc

... proliferation and collagen synthesisinvolve the b-catenin signaling pathway. Inhibition of b-catenin signaling pathway usingquercetin blocked the a-defensin-inducedincrease in collagen release ... signaling pathway. We then studied the roleof the b-catenin signaling pathway in a-defensin-induced increases in the proliferation and collagen syn-thesis of lung ﬁbroblasts using quercetin. ... ﬁbroblasts.Inhibition of the b-catenin signaling pathway using quercetin blocked the a-defensin-inducedincrease in lung ﬁbroblast proliferation and collagen synthesisTo investigate the role of b-catenin activation...

Báo cáo khoa học: A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+ ppt

... residues in the ﬂanking helices and loopare conserved compared with EF-hand III in CaM and the STIM1 EF-hand, such as position 8 in the loop,)8, )5, )1 in the E helix and +4, +5 in the F helix,which ... proposed Ca2+-coordinating ligands in italic) was inserted into the host pro-tein CD2 domain 1 between residues S52 and G53 with threeGly at the N-terminus and two at the C-terminus (denotedas ... non-Ca2+-bindingEF-hand motif that stabilizes the intramolecular inter-action between the canonical EF-hand and the SAMdomain. This hidden EF-hand pairs with the upstreamcanonical EF-hand through...

Báo cáo khoa học: Molecular dynamics structures of peptide nucleic acidÆDNA hybrid in the wild-type and mutated alleles of Ki-ras proto-oncogene ppt

... tointerrupted stacking, ﬂuctuating nature of the hydro-gen bond and water organization in the vicinity of the mismatch might be the contributing factors for the increase in free energy and diminished stability ... mismatch brings about signiﬁ-cant reduction in adjacent base stacking in PDwtcompared to PDmut.On the other hand, stacking at the AC(6–7) step in the DNA strand of PDwtis retained during the ... hence, diminution of the melting temperature (Tm) in the former.Base stacking in the vicinity of A C mismatch in PNAÆDNA and DNA duplexesIntra strand base stacking at the AC(6–7) (Fig. 2A)...

Báo cáo khoa học: Molecular characterization of Osh6p, an oxysterol binding protein homolog in the yeast Saccharomyces cerevisiae pot

... PtdIns(5)P,PtdIns(3,4)P2 and PtdIns(3,5)P2with the strongestbinding to PtdIns(5)P (Fig. 1). The ORD domainshowed a very similar lipid binding pattern as the full-length protein. While the ... structures. At 10 min,punctate staining diminished and vacuolar staining in- creased, and ﬁnally punctate staining was almost lostwith predominant vacuolar staining at 30 min. Com-pared with ... provided invaluable in- sights into understanding the function of this familyof proteins in yeast and offered guidance to futureresearch. On the other hand, although the entire Oshprotein family...

Báo cáo khoa học: Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain pdf

... bridges in the analogs withrespect to their adenosine moieties.Details of the syntheses will be published elsewhere, and we present, in the Supporting information, only the keysteps leading to the ... competitive inhibitors, with Kivaluesof 2.2 lm (3) and 1.5 lm (4) for the lupin enzyme and of 2.1 lm (3) and 2.5 lm (4) for the human counter-part. These Kivalues lie in the range of the Kmvaluesfor ... asymmetrically acting Ap4A hydro-lases can reach the scissile bond either by extending the frame’, as in the case of compound 3,orbyshortening the count, when attacking the Pb-O-Pb¢bond...

Báo cáo khoa học: "A Graphical Interface for MT Evaluation and Error Analysis" doc

... both the candi-date and the reference translations. However, the current command-line interface returns the resultsonly in text mode and does not allow for fully ex-ploiting this linguistic information. ... divided by the cardinality of their union. The example in Table 1 shows the counts used to cal-culate Ol between the reference and two candidatetranslations (boldface and underline indicate non-matched ... purposes, parse trees com-bine the grammatical relations and the grammati-cal categories of the words in the sentence and dis-play the information they contain. Figure 2 and 3show, respectively,...

Tài liệu Báo cáo khoa học: Pyruvate reduces DNA damage during hypoxia and after reoxygenation in hepatocellular carcinoma cells pptx

... reoxygenation but is ineffective atmaintaining glutathione levels during hypoxiaGlutathione is one of the main antioxidant compounds in the cell, and it is also essential for DNA synthesis and repair ... lactate and alanine. This is due to the blockade of the tricar-boxylic acid cycle induced by lack of oxygen. Weexamined the peaks corresponding to the glutathionecarbons, and quantiﬁed the relative ... underlying the pyruvate effects has yet to be further examined. In light of the data in the literature and our workwith HepG2 cells, we concluded that pyruvate mightact similarly in tumor cells and...

Tài liệu Báo cáo khoa học: "Arabic Tokenization, Part-of-Speech Tagging and Morphological Disambiguation in One Fell Swoop" pdf

... in each of the development and test corpora, and 120,000 words in each of the train-ing corpora. We will refer to the training corpora asTR1 and TR2, and to the test corpora as, TE1 and TE2. ... Proper Nounresulting from missing entries in the Buckwalter’slexicon. The remaining case was a failure in the conversion process relating to the handling of bro-ken plurals at the lexeme level. ... choosing the correct analysis, measured per token (including and excluding punctuation and numbers); BL is the base-linesiﬁers on TR2. The difference in performance be-tween TE1 and TE2 shows the...

Tài liệu Báo cáo khoa học: "A Lexicon for Exploring Color, Concept and Emotion Associations in Language" doc

... luck in Nigeria and Ger-many and reﬂects ambition and desire in India.Some expressions involving colors share the same meaning across many languages. For in- stance, white heat or red heat (the ... tra-ditions and beliefs of a society. As shown in (Sable and Akcay, 2010) green represents danger in Malaysia, envy in Belgium, love and happiness in Japan; red is associated with luck in China and Denmark, ... in conveying emotion, obtaining adeeper understanding of the associations between colors, concepts and emotions may be helpful formany tasks in language understanding and gener-ation. A detailed...

Báo cáo khoa học: Recombinant bovine zona pellucida glycoproteins ZP3 and ZP4 coexpressed in Sf9 cells form a sperm-binding active hetero-complex ppt

... contamination by the other rZPGs and examined the sperm-binding activity and complex formation ofthese rZPGs. We also created deletion mutants ofrecombinant (r)ZP4 to examine whether its N-terminalregion ... N-linked chains in these proteins. Native bovine ZP2 has three N-linkedchains [40], but the numbers of N-linked chains in native bovine ZP3 and ZP4 have not been reported.Therefore, whether the ... forformation of the sperm-binding active bovine rZP3 ⁄ rZP4 complex and, furthermore, that the molecular interactions between rZP3 and rZP4 areconserved in the bovine and porcine systems.AbbreviationsACA,...

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