Báo cáo khoa học: Novel brain 14-3-3 interacting proteins involved in neurodegenerative disease doc

... Novel brain 14-3-3 interacting proteins involved in neurodegenerative disease Shaun Mackie* and Alastair Aitken University of Edinburgh, School of Biomedical and Clinical Laboratory ... serine 1094 in the equiv- alent site in the mouse homologue (in a consensus binding motif for 14-3- 3) abolished 14-3-3 binding to d-catenin in vitro and in transfected cells. d-ca...

Ngày tải lên: 16/03/2014, 22:20

... strains 1200 and 1268 are representa- tive of this LPS structural motif in H. in uenzae. One glycoform containing full extension from both HepII and HepIII was identified in minor amounts in strain ... within the human respiratory tract, at least in part by mediating bacterial adherence to and invasion of the host epithelia [34–36]. A major- ity of H. in uenzae strains, including NTH...

Ngày tải lên: 16/03/2014, 05:20

... portions in P1 that are more informa- tive than portions in P2 (forward entailment). In such cases, the entailing (more informative) portions from P1 have to be translated and migrated to P2 in order ... complement them; (4) Text portions in P1 describing facts that are not present in P2, and vice-versa (the “unknown” cases in RTE parlance). In such cases, the novel infor- m...

Ngày tải lên: 19/02/2014, 19:20

... determined that AOP2 was absent from porcine, murine, and human plasma (data not shown). To gain insight into how AOP2 interacts with itself or other proteins, RBC stroma proteins were examined using native ... hemoglobin in RBC lysate. Cysteine 47 is essential for AOP2-heme binding The binding of AOP2 and heme led us to investigate the mechanism by which AOP2 binds to heme. All peroxire...

Ngày tải lên: 20/02/2014, 23:20

... MS) allowed us to investigate the N-terminal processing of CGA in rat heart extracts. Our data reveal the pres- ence of several vasostatin I-containing and vasosta- tin II-containing peptides in the CGA(1–199) ... processes vasostatin-containing peptides. This strongly suggests that these fragments play a role in the autocrine ⁄ paracrine regulation of cardiac function, being directly...

Ngày tải lên: 07/03/2014, 12:20

... between words in conjuncts. 1 Introduction Coordination remains one of the challenging prob- lems in natural language processing. One key characteristic of coordination explored in the past is ... listed above are concerned mainly with scope disam- biguation, reflecting the fact that detecting the presence of coordinations in a sentence (Task 1) is straightforward in English. Indeed,...

Ngày tải lên: 08/03/2014, 01:20

... number of keyword extracted per docu- ment in the training set is 6.4 and in the test set 6.1 (not counting the empty documents). Keywords Training docs Test docs 0 54 14 1 68 36 2 829 272 3 2 ... to the baseline. The best performance was obtained when using a boolean feature value, and setting the minimum number of occurrence in training data to three (giving an F-measure of 56.9%). I...

Ngày tải lên: 08/03/2014, 02:21

... protein kinase; MMP, matrix metalloproteinase; NF-jB, nuclear factor kappa B; PI3K, phosphatidylinositol 3-kinase; PKC, protein kinase C; Pyk2, proline-rich tyrosine kinase 2; RTK, receptor tyrosine ... (1993) High affinity binding and direct antiproliferative effects of luteinizing hor- mone-releasing hormone analogs in human endome- trial cancer cell lines. J Clin Endocrinol Metab 77, 1458...

Ngày tải lên: 16/03/2014, 04:20

... happening in (lo- cation) or done by the kidney. Immunoglobulin stain- ing, (D12 -Amino Acids, Peptides-, and Proteins, E05 - Investigative Techniques-) can mean either staining with immunoglobulin ... from training instances, achieving about 60% accuracy on an 18-way classification problem us- ing a very small training set. That approach is bottom up and requires good coverage in the tra...

Ngày tải lên: 17/03/2014, 08:20

... 915 Protein kinase Ch activity is involved in the 2,3,7,8- tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line Sohel ... expressed in L-MAT, a human lymphoblastic T-cell line. In this report, we provide the following evidence that the protein kinase C (PKC)h activity is func- tionally involved in the Ah...

Ngày tải lên: 23/03/2014, 13:20