Báo cáo khoa học: PA700, the regulatory complex of the 26S proteasome, interferes with a-synuclein assembly pptx

... character- istic of the closed conformation. It further strengthens the contact of the Arg side chain with bL, already formed in the binary complex with 3-PG. The forma- tion of a new H bond in the closed ... substrate to one of the two domains can also stabilize the structure of the other domain [32–34]. Often the results of studies with the solubili...

Ngày tải lên: 16/03/2014, 18:20

... subcomplex, while the remaining four subunits (NdhH–K) form the connect- ing subcomplex, both of them homologous to the bac- terial subcomplexes. The theoretical molecular mass of the Ndh complex, ... transcription of the ndh genes is much higher in BS chloroplasts, and elevated amounts of the Ndh complex have been found in these plastids [18]. The function of th...

Ngày tải lên: 23/03/2014, 13:20

... disappearance of the heavier inactive peak. Furthermore, FPLC analysis of the recombinant wild-type cN-II showed the presence of the tetrameric active form irrespective of the pres- ence of effectors. ... determine the value of K 50 for these compounds. Under these experimental conditions, the accu- mulation of radiolabelled inosine (nucleotidase activity) rep- res...

Ngày tải lên: 15/02/2014, 01:20

... superposed with the PRTFDC1 structure, a water molecule is found at approximately the same distance from N7 of the guanine base as is the oxygen of the aspartic acid side chain in the HPRT complex ... where the confor- mation is also stabilized by crystal contacts [24]. The bound phosphate ion superposes well with one of the phosphates of pyrophosphate in the...

Ngày tải lên: 15/02/2014, 01:20

... whether these cytokines are produced by CD4 + CD25 + Foxp3 + T reg or whether they induce the production of these cytokines from another population of cells [20]. To date, our knowledge about the ... domains impor- tant in the functioning of these transcription factors. The gene organiza- tions of zebrafish t-bet and foxp3 were identical to those of the human genes, with...

Ngày tải lên: 16/02/2014, 09:20

... stabilization of active RhoA by OTUB1 prior to bacterial invasion. The accumulated pool of active RhoA contributes to an enhanced uptake in the early phase of invasion, con- sistent with the involvement of ... Kessler Department of Clinical Medicine, University of Oxford, UK Introduction The genus Yersinia consists of three pathogenic species that are agents of a var...

Ngày tải lên: 16/02/2014, 15:20

... respectively. Although the over- all number of these modifications is low, the density of modifications is much the same as in the rest of the lin- ker histones. It is the shortness of the N-terminal tails Table ... histones Historically, the location of the globular domain of the linker histone has been a matter of contention [13]. Currently, although there is...

Ngày tải lên: 18/02/2014, 08:20

... functions. The gene encoding the cyclin-depen- dent kinase inhibitor p21 is a target gene of SREBP [20]. This finding suggests that the regulation of lipid synthesis is linked to the regulation of cell ... where the site 1 and site 2 proteases cleave the SREBPs [3,4]. Upon restoration of cellular cholesterol, Insig, another key regulator of ER membrane proteins, traps and...

Ngày tải lên: 18/02/2014, 13:20

... PAGE of the resulting pellets. (C) The amounts of I C in the pellets. The amounts of I C were quantitated with the UN-SCAN-IT gel program (Silk Scientific Corporation, Orem, UT) using the band of purified ... phospholipid and membrane binding of the other members of the PEBP family. Consequently, the binding characteristics of PEBP proteins, including those of...

Ngày tải lên: 19/02/2014, 05:20

... of interacting proteins responsible for the control of gene expression. They interact with DNA regions and tend to form transcriptional regulatory complexes. Thus, the final effect of one of these ... The relatively small size of the con- nected graph compared with all the entries in the data- base might be due, at least in part, to the current degree of knowled...

Ngày tải lên: 19/02/2014, 07:20