Báo cáo khoa học: Identification and characterization of four novel peptide motifs that recognize distinct regions of the transcription factor CP2 doc
Báo cáo khoa học: Identification and characterization of four novel peptide motifs that recognize distinct regions of the transcription factor CP2 doc
... (2005) 1265–1277 ª 2005 FEBS 1277 Identification and characterization of four novel peptide motifs that recognize distinct regions of the transcription factor CP2 Ho Chul Kang1, Bo Mee Chung1, ... CP2 and YY1 via the HXPR sequence.Mapping the sites on CP2 for interaction with the four distinct CP2- bind-ing motifs revealed at least three different regions on CP2. This suggests that CP2 recognizes ... effect of YY1 on CP2. We also demonstrated that, unlike the HXPR and ASR motifs, PHL and PXHXH motifs bind to the N- and C-terminal parts of the Elf-1 domain on CP2, respectively (Fig. 3). Becausethe...
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
... that there is a relationshipbetween the expression of these transcription factors and the cytokine genes known to be produced by dif-ferent T-cell subtypes in mammals. These transcription factors, ... between the expression of t-bet, stat6 and foxp3 with other genes involved in Th and Tregresponsesusing quantitative PCR. These transcription factors, together with many of the cytokines that ... expression of T-bet has beenseen within a wide variety of tissues and cells in the Ginbuna crucian carp [27] and, in mammals, in the lung tissue of mouse and spleen and thymus of human and mouse...
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Tài liệu Báo cáo khoa học: Identification and characterization of an R-Smad ortholog (SmSmad1B) from Schistosoma mansoni pdf
... increased the interaction of SmSmad2 with SmGCN5, but also revealed the interaction of SmSmad4 with SmGCN5 and demon-strated its participation in the formation and, prob-ably, the stabilization of the ... above.Unlike most transcription factors that are sufficientto recruit the basal transcription machinery and therefore activate transcription on both naked and chromatin templates, the Smads only ... pathway in schistosomes and to probe the role of SmSmad1B beyond its interaction with Sm-Smad4 and the formation of a Smad complex. The transcription factors p300 ⁄ CBP and GCN5 possess anintrinsic...
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Báo cáo khoa học: Identification and characterization of a nuclear receptor subfamily I member in the Platyhelminth Schistosoma mansoni (SmNR1) pot
... acids at the 5¢ end of the DBD, the DBD and the 40 amino acids at the 3¢ end of the DBD of SmNR1 (Ile247-Ser372) and SmRXR1 (Glu251-Asn376)were tested in vitro. Lanes 1, 5, 9, 13, 17, 21, 25 and ... 6A). The results sugges-ted that both full-length and the A ⁄ B domain of SmNR1 activated transcription of GAL4 reporter genein the absence of ligand, while the C-F domain didnot. Thus the ... most NRs, and the length of the hinge in SmNR1 thus can beestimated to be 140 amino acids. The role of the large hinge in schistosome NRs remains unknown. The degree of conservation of the LBD...
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Báo cáo khoa học: Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress pdf
... nm. The per-centage of H2O2removed was calculated on the basis of the change in A490obtained with Bcp2 relative to that obtained without Bcp2.Thermophilicity and thermoresistanceThermophilicity ... studies have shown that the only cysteine, Cys49, present in the Bcp2 sequence, is involved in the catalysis. Lastly, the presence of thisCys in the sequence confirms that Bcp2 is the first archaeal ... periods of time(Fig. 3). As shown, the addition of stressors to the cul-tures inhibits growth without killing the cells. The hybridizing band in the northern analysisshowed the expected size of...
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Báo cáo khoa học: Identification and characterization of B¢¢-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues Evidence for an independent N-terminal splice variant of PR130 and an extended human PR48 protein pot
... analysis of the structure of the latter made it possible to improve the currentknowledge of the mammalian PR48 cDNA. To extend thesefindings, the genomic structures of the human PR130 and PR48 ... GemeenschapÕ, the Fonds voor Wetenschappelijkonderzoek Vlaanderen¢, V. J. and C. V. H. are postdoctoral fellows of the F.W.O. Vlaanderen; I.S. is holder of a postdoctoral fellowship of the Ôonderzoeksfonds ... different classes of cDNAs were isolated and analysed. The first is the Xenopus orthologue of PR130, the second proved to be a novel splice variant and the third is the Xenopus orthologue of PR48. Moreover,...
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Báo cáo khoa học: Identification and characterization of plasma kallikrein–kinin system inhibitors from salivary glands of the blood-sucking insect Triatoma infestans pptx
... [55].Expression and purification of the recombinantN-terminal region of FXII and domain D5 of HKExpression vectors for the recombinant N-terminal region of FXII and domain D5 of HK were constructed ... Matsuoka H, Ando K, Watanabe T, Suzuki Ket al. (1996) Purification, characterization and cDNAcloning of a novel anticoagulant of the intrinsic path-way, (prolixin-S) from salivary glands of the bloodsucking ... endothelial cell surface, and isthen accelerated by the reciprocal activation of FXII and PK on the surface. Zn2+is essential for binding of FXII and HK to a biological activating surface,and...
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Báo cáo khoa học: Identification and characterization of oxidized human serum albumin A slight structural change impairs its ligand-binding and antioxidant functions pptx
... with the excep-tion of the other peaks in the cysteinylated HSA sam-ple solution. The difference of relative molecular mass of the peak d and the peak g (162.2 Da) and that of peak c and peak ... 91% with the excep-tion of the other peaks in the homocysteinylated HSAsample solution. The difference of relative molecular masses of peaksh and j (161.7 Da) and those of peaks c and e(162.9 ... as an endogenous ligandwhich binds to site II, and of cefazolin (site I-ligand) and verapamil (site I and II-ligand) as exogenous lig-ands. All these ligands are known for their high bind-ing...
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Báo cáo khoa học: Identification and characterization of novel PKA holoenzymes in human T lymphocytes pdf
... twoprotein bands of 40 and 47 kDa, respectively (Fig. 1B).All of these antibodies were raised against regions in the C subunit that are conserved and therefore do notdiffer significantly between the ... phosphoryla-tion of the nuclear factor of activated T cells [18] and nuclear factor jB [19]. The fact that human T cellsexpress two distinct C subunits (Ca1 and Cb2) whichmay be associate on the same ... antibody-immobilized Cb2 isoform wouldremain in the pellet in the absence of 8-CPT-cAMPwhile they would be released to the supernatant in the presence of 8-CPT-cAMP. The precipitates and supern-atants...
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Báo cáo khoa học: Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis potx
... or dimerization of the polypeptide chain. The CD spectrum of the mutant was identical to that of the wild-type enzyme, and gel filtration showed that, like the wild-type enzyme, the mutant enzyme ... also propose that the hydropho-bic pocket plays a role in substrate discriminationagainst binding of the 5-OH group of Kdo and infavour of the N-acetyl group of Neu5Ac and, although these residues ... under-stand the pathway of sialylation in detail to enable the design and produc-tion of inhibitors and mimetics. Sialylation occurs in two stages, the first toactivate sialic acid and the second...
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