Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt

... Biochem. 27 1) Ó FEBS 2004 Structure, expression and regulation of the cannabinoid receptor gene ( CB1 ) in Huntington’s disease transgenic mice Elizabeth A. McCaw, Haibei Hu, Geraldine T. Gomez, Andrea ... describing the gene structure of CB1 and i ts pattern of expression in transgenic mice will provide the information necessary to dete...

Ngày tải lên: 16/03/2014, 18:20

... of several pathologies and because of the potential use of the toxins as biological weapons. Alteration of their MHC and TCR binding capacity by site directed mutagenesis could be useful in the ... on the opposite f ace of the molecule that is Zn 2+ dependent [14,15]. The proinflamatory and procytotoxic properties of SAgs are r esponsible for the increased int...

Ngày tải lên: 07/03/2014, 16:20

... protein ligand tethering the co-enzyme in a productive mode within the active site and stabi- lizes the protonated N( 1) of the co-enzyme to strengthen the electron-withdrawing capacity of the co-enzyme ... function instead in subgroup Ib [18]. Arg386 of the small domain binding the a-COO ) of the substrate plays a key role in the activity of the...

Ngày tải lên: 14/03/2014, 23:20

... they may link a guanine on the top of the stack to a guan- ine on the bottom, resulting in a double-chain reversal loop. Further details and images are available in Phan [11]. The nature of the ... (200 9) The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implica- tions for dr...

Ngày tải lên: 23/03/2014, 03:20

... terminus, which allows cloning in- frame with alanine as the first amino acid of the mature protein. An alignment of the amino acid sequences of 11 family-74 catalytic domains shows that their amino ... between the glucose standard curve and the nmoles of XGOs produced was determined for both the PAHBAH and the bicinchoninic acid reducing sugar methods. For the PAH...

Ngày tải lên: 23/03/2014, 21:20

... domain of t-bet, the STAT protein inter- action domain, STAT protein all-alpha domain, STAT protein DNA-binding domain and SH2 domain of stat6, and the zinc-finger domain, leucine-zipper domain and ... containing the t-bet and foxp3 genes. Around t-bet, the genes TBK1-bind- ing protein 1, oxysterol-binding protein-like 7 (OS- BPL 7) and mitochondrial ribosomal protein...

Ngày tải lên: 16/02/2014, 09:20

... directly repress the transcription of insulin receptor substrate-2 (IRS- 2), the main insulin signaling molecule in the liver and pancreatic b-cells [8,26]. Suppression of IRS-2 by SREBP-1c in the liver inhibits ... transcription factors by Gold- stein and Brown, is involved in the regulation of genes participating in cholesterol biosynthesis and low-densit...

Ngày tải lên: 18/02/2014, 13:20

... contains all the SMAD proteins of the HTFN and APC and b-catenin-related factors. Groups C and D involve smaller functional sets. Group C contains the Rel family and CRE binding factors involved in ... features and the features are gener- ated by two distinct evolutionary strategies: amplification and shuffling of interacting domains through tinkering and acquisition...

Ngày tải lên: 19/02/2014, 07:20

... 516. This resulted in insertion of a 10 amino acid segment (TREIDYPETI) and one substitution (Ser fi Gly) at the C-terminal end of the insertion (Fig. 1B). To examine the origin of the two proSpa ¨ tzle-1 ... reported in other genes, such as human and Drosophila G s a (the a-subunit of the guanine nucleotide-binding protein) isoforms [41,42]. ProSpa ¨ tzle-1 mRNA was...

Ngày tải lên: 06/03/2014, 09:22

... of CYP719A3, the amount of nandinine produced was estima- ted by using the calibration curve of (S)-scoulerine (pmol versus peak area) and the absorption ratio of (S)-scoulerine and (S)-nandinine ... reported to increase in response to MeJA together with those of other P450s involved in sanguinarine biosynthesis in EB DA C Fig. 8. MeJA induces the expression of...

Ngày tải lên: 07/03/2014, 10:20