Báo cáo khoa học: Brain succinic semialdehyde dehydrogenase Reactions of sulfhydryl residues connected with catalytic activity pdf

... Brain succinic semialdehyde dehydrogenase Reactions of sulfhydryl residues connected with catalytic activity Byung Ryong Lee 1 , Dae Won Kim 1 , Joung-Woo ... instructions. Results Inactivation of succinic semialdehyde dehydrogenase by DABIA The r elevance of sulfhydryl groups in the catalytic activity of SSADH, was examined by reacting the enzyme wi...

Ngày tải lên: 16/03/2014, 18:20

... different regions of the eye. The expression of cN in the central regions of the lens, fiber cells that were laid down before birth, is consistent with the familiar pattern of expression of the principally ... associated with photoreceptor disc shedding [48]. In evolution, functional retinas preceded the evolution of a focusing lens [3,49]. The proteins of the lens arose by t...

Ngày tải lên: 19/02/2014, 17:20

... site of pHbApr1neo [22] and sequenced fully in both directions. Chimera 1V2 encoded residues 1–652 of TAP1 and residues 640–703 of TAP2 and chimera 2V1 encoded residues 1–639 of TAP2 and residues ... [9]. Chimera 1C2 encoded residues 1–505 and 653–725 of TAP1 and residues 494–639 of TAP2 and chimera 2C1 encoded residues 1–493 and 640–703 of TAP2 and residues 506–...

Ngày tải lên: 20/02/2014, 02:21

... enzymatic activity of all MATs studied depends on the redox state of the sulfhydryl moieties on the cysteine residues in the amino acid sequence of the protein [10]. Chemical modification of bacterial ... loss of AdoMet synthesis activity compared to the wild type, and the C33S and C47S mutants retained a mere 12% of wild-type MAT activity. C106S mutant activity and kine...

Ngày tải lên: 08/03/2014, 08:20

... exhibit vasomotion activity (i.e. a rhythmic oscillation of ves- sel diameter) in the absence of disease. This activity coincides with an oscillation in the intracellular Ca 2+ concentration of vSMCs. ... particular, the concept of a ‘neurovascular unit’ that encompasses neurons, vessels and other types of cells located at their interface has become one of the main themes o...

Ngày tải lên: 18/02/2014, 11:20

... ischemic and still viable region of the brain called the ‘penumbra’ [14]. Therefore, degree of angiogenesis appears to correlate with rate of recovery from stroke. A variety of angiogenic factors such ... biochemically. The affinity of VEGFR-1 for VEGF-A is extremely high (K d = 1–10 pm), 10-fold that of VEGFR-2. However, the tyrosine kinase activity of VEGFR-1 is one order...

Ngày tải lên: 18/02/2014, 11:20

... called a brain attack) refers to a hetero- geneous spectrum of conditions caused by the occlu- sion or hemorrhage of blood vessels supplying the brain, and is one of the major causes of death ... reinter- preted in the context of angiogenesis in the brain. Is it possible that some of the acute neurovascular events in the brain after stroke represent an endogenous attempt by...

Ngày tải lên: 18/02/2014, 11:20

... the serum of patients with degenerative liver diseases [15–17]. In addition, high levels have been measured in the cerebrospinal fluid of children with cerebral malaria and in the brain of a murine ... protein. Inspec- tion of the residues which in ACMSD I mark the boundary of the predicted substrate-binding pocket, reveals that some of them are conserved in the inac- tive...

Ngày tải lên: 19/02/2014, 02:20

... characterization of HpSDH demonstrates its activity with k cat of 7.7 s )1 and K m of 0.148 mm toward shikimate, k cat of 7.1 s )1 and K m of 0.182 mm toward NADP, k cat of 5.2 s )1 and K m of 2.9 mm ... investigated the catalytic proper- ties of HpSDH and the effects of pH and temperature on HpSDH. The results show that HpSDH has a k cat of 7.7 ± 0.9 s )1 , K m of...

Ngày tải lên: 19/02/2014, 05:20

... contribution of Xdh1 is minor compared to that of Lad1, which is therefore of major importance for the L -arabinose catabolic pathway of H. jecorina. Because of the poor catalytic efficacy of Lad1 ... specificity of Lad1 with that of mammalian SDHs shows that Lad1 has a much higher catalytic efficacy with pentitols than with hexitols. It is therefore intriguing that all...

Ngày tải lên: 07/03/2014, 15:20