Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1 pptx

... FEBS 2004 Alternative initiation of transcription of the human presenilin 1 gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation of presenilin 1 Martine Pastorcic 1 and Hriday ... in Ets and Sp1 motifs on PS1 promoter activity. The positions of Ets (d) and Sp1 (h)motifsinthe )11 9/ +17 8 region of the PS1...

Ngày tải lên: 16/03/2014, 18:20

... diffuse into the cytosol of L. donovani infected macrophages and inactivate them [74]. EF-1a plays an important role in eukaryotic pro- tein biosynthesis by binding aminoacyl-tRNAs and positioning them ... 913 –963. 36 Pain VM (19 96) Initiation of protein synthesis in euk- aryotic cells. Eur J Biochem 236, 747–7 71. 37 Hershey JWB & MW (2000) Pathway and mechanism...

Ngày tải lên: 23/03/2014, 10:20

... sites) and their proximities (branch points). Other cis-acting elements involved in the deter- mination of the splicing outcome are recognized by trans-acting factors that can either act as splicing silencers ... aberrant isoforms altering the essential protein func- tion are produced. In this review we briefly describe the current under- standing in the field and discus...

Ngày tải lên: 06/03/2014, 09:22

... Italy Introduction Towards the end of the 19 70s, in the beginning of pre-mRNA splicing research [1, 2], defining exons and introns was essentially based on observing the final composition of the mature ... is linked to chromosome 12 q23.3-24 .11 and caused by an intron mutation in the ISCU gene resulting in a splicing defect. Hum Mol Genet 17 , 16 66 16 72. 11...

Ngày tải lên: 06/03/2014, 09:22

... sites in SLS3 and in agreement with the strong activation properties of these proteins on site A3 [29], several of their binding sites overlap the hnRNP A1 binding sites. However, SC35 binding on the ... further understanding of infection, spread and dissemination through splicing regulation. Such stud- ies coupled with the testing of splicing inhibitors should help...

Ngày tải lên: 06/03/2014, 09:22

... increases the transcription of repressed genes by disruption of nucleosome position- ing around their promoters. These data will facilitate the understanding of the role of BrdU and AT-tracts in the induction ... positioning We examined two derivatives of pRS-BAR1, pRS0 01- BAR1 and pRS8 01- BAR1, containing T 3 CCT 6 CT 5 GCT 5 CT 7 and A 34 , respectively, in...

Ngày tải lên: 15/03/2014, 23:20

... naturally occuring FtGLDH AA and the artificial AtGLDH1 AA , are indeed exclusively due to the insertion of two additional alanyl residues into the N-terminus of the H-protein. In conclusion, the substrate ... NaH 14 CO 3 (2.5 lCi), 9 lg matrix protein and 0 10 0 lm H-protein in a total volume of 15 0 lL. H-protein concentrations varied as indicated in the figures...

Ngày tải lên: 23/03/2014, 04:20

... representation of the crystal structure of the digoxi- genin-binding anticalin DigA16 (PDB entry 1LKE). The bound ligand is shown in a space-filling representation in yellow, whereas the 16 amino acid ... fluorescein dianion and a Trp side chain in the binding site of the engineered lipocalin, which closely packs against the xanthenolone moiety [26]. This phenomeno...

Ngày tải lên: 23/03/2014, 07:20

... approach (Klein and Manning, 2003) consists in adding head information to dependents; words tagged with VBP are then split into classes according to the words that dominate them in the training corpus. Some ... close to 1 (and 0 MS) for all values of alpha. Hence, there is no need to introduce further distinctions in DT, doing so will not increase the quality of the aut...

Ngày tải lên: 23/03/2014, 19:20

... Ile174 (1) C3 Val18(2) Val53(2), Ile174 (1) C4 Leu134 (1) Val53 (1) , Ile66 (1) , Ile174(2) C5 Ala 31( 1), Leu134 (1) Val53 (1) , Ile66 (1) , Ile174 (1) C6 Ile10 (1) , Leu134 (1) , Ala 31( 1) Val53(3), Ile174 (1) C7 ... chain atoms of the hinge region. The N1 atom of the adenine hydrogen bonds to the main chain nitrogen of Leu83 while the N6 group hydrogen bonds to the m...

Ngày tải lên: 23/03/2014, 21:20