... legumain with Z-Ala-Ala-Asn-AMC as the substrate, while stopped assays were performed forcathepsins K, S and B using Z-Phe-Arg-AMC as the sub-strate and for cathepsin H with Arg-AMC as the substrate[6]. ... other then known families of cysteine pro-tease inhibitors. Clitocypin inhibits papain, cathepsins Land K, legumain and bromelain, but is inactive againstcathepsin H, trypsin and pepsin. Clitocypin ... inhibitors of cathepsin L, mainly because of increased rate constants of dissociation. Cathepsins S and K are inhibited bymacrocypins with Kivalues in the nanomolar range,while clitocypin inhibits...