Báo cáo khoa học: Structure and topology of the transmembrane domain 4 of the divalent metal transporter in membrane-mimetic environments docx

... FEBS 20 04 Structure and topology of TM4 of DMT1 (Eur. J. Biochem. 271) 1951 Structure and topology of the transmembrane domain 4 of the divalent metal transporter in membrane-mimetic environments Hongyan ... Synthesis and biophysical analysis of transmembrane domains of a Saccharo-myces cerevisiae G protein-coupled receptor. Biochemistry 39,1 546 2–1 547 4.Ó FEBS 20 04 Structure and topology of TM4 of ... group of SDS molecules.Whether the C-terminus has a regulative role in metal transport remains to be investigated further.It is of interest to investigate whether the peptide isinserted into the...

Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf

... Phosphorylation of histone H3S10 by Pim1 kinase enables the recruitment of both MOF and P-TEFb via interactions involving the adaptor protein 14- 3-3 and the bromodomain pro-tein BRD4 which is recruited ... to promote GATA-1 binding tochromatin [ 244 ]. In some cases there is a clear hierar-chy in binding. Steroid receptors can bind to nucleo-somes and promote the binding of other factors suchas ... ﬂanking the 5¢ and 3¢ ends of the ovomucoidgene and the ovalbumin and its related X and Y genes in hen oviduct nuclei. Biochemistry 19, 44 03 44 41.57 Wood WI & Felsenfeld G (1982) Chromatin...

Tài liệu Báo cáo khoa học: Structure and function of plant aspartic proteinases pptx

... representation of the structure of the PSI domain of barley prophytepsin [25] (N-terminal domain, blue; C-terminal domain, red). (C) Model structure of the PSI domain of cardosin A based on the crystal structure ... feature of the PSI is the swap of the N- and C-terminal portions of the saposin-like domain, where the C-terminal portion of one saposin is linked to the N-terminal portion of the other saposin. ... ChlamydomonasFig. 3. The ‘saposin fold’. (A) Ribbon representation of the structure of NK-lysin, a saposin-like protein [26]. The N-terminal domain is shown in blue and C-terminal domain in red. (B) Ribbon...

Tài liệu Báo cáo khoa học: Structure and membrane interaction of the internal fusion peptide of avian sarcoma leukosis virus pdf

... on the N-terminal FP, it wouldbe of interest to compare the structure of the internal FP and i ts interaction w ith membrane bilayer, including in particular the structural in uence of proline. ... Kantchev and Ding-Kwo ChangInstitute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China The structure and membrane interaction of the internalfusion peptide (IFP) fragment of the avian ... N-terminalFP.Self-quenching of rhodamine ﬂuorescence indicatesself-assembly of IFP–wt in the lipid bilayerTo further examine the organization of the fusion peptide in the membrane, the peptide...

Báo cáo khoa học: Structure and function of KH domains docx

... edge of the b2-strand), where it con-tacts both the invariant GXXG motif and the variableloop.Nucleic acid binding by tandem but independentKH domains – NMR structure of the KH3 and KH4domains ... A45) is buried in and across the groove between the a1-helix and a2-helix and the b2-strand of KH1. Intimate contactsbetween protein and RNA continue across the cusp of the KH1 and KH2 domains. ... of KH2, and U47 and C48 make contacts with the a1-helix and the GXXG loop of KH2. Finally, the nucleotides at the 3¢-end of the RNA (A49–A52) pack against the groove comprising the a1-helix and...

Báo cáo khoa học: Structure and mechanism of the ThDP-dependent benzaldehyde lyase from Pseudomonas ﬂuorescens potx

... domains consist of a cen-tral six-stranded parallel b-sheet ﬂanked by a varyingnumber of a-helices. Residues involved in binding of the cofactor ThDP are located at the C-terminal ends of the ... ThDP in the V-conformation that brings the C2 atom of thiazo-lium in close proximity to the N4¢ atom of the pyrimidine moiety. Moreover, one of the reportedstructures of ALS [18] contains an inhibitor ... those of other ThDP-dependent enzymes [23]. In all enzymesThDP assumes a V-conformation resulting in a closeapproach between the C2 atom of the thiazolium ring and the N4¢ atom of the pyrimidine...

Báo cáo khoa học: Structure and function of N-acetylglucosamine kinase Identiﬁcation of two active site cysteines pptx

... ATP-bindingsubdomains, indicating a common structure of the ATP-binding sites of the two enzymes. Interestingly, ﬁve of the sixcysteines of GlcNAc kinase had an equivalent cysteine in glucokinase, ... of glucokinase was used [23]. Based on the sequence align-ments of glucokinase and GlcNAc kinase and the commonATP-binding domain, the GlcNAc kinase was ﬁtted into the glucokinase model using ... comparable to the hexokinase subunits [ 24] . Onelobe consists of the phosphate1 subdomain and the predicted a-helix I. The other lobe consists of the phos-phate2 and the adenosine subdomains, the predicted...

Báo cáo khoa học: Structure and potential C-terminal dimerization of a recombinant mutant of surfactant-associated protein C in chloroform/methanol ppt

... 600 40 96 · 768 40 96 · 10 24 70 11NOESY 600 40 96 · 768 40 96 · 10 24 50 8NOESY 600 40 96 · 768 40 96 · 10 24 100 8NOESY 600 40 96 · 768 40 96 · 10 24 200 8DQF-COSY 600 40 96 · 10 24 4096 · 10 24 – 12 4. 4 ... proteins [13] using the computer programNDEE(Spin Up, Lu¨nen, Germany).Owing to the high abundance of the amino acids valine,leucine and isoleucine in the sequence of rSP-C (FFI), therewas ... Gly33 and Leu 34, which differ mainly in the chemical shifts of the amideprotons and the c protons of Ile32 and Leu 34. A compar-ison of the spectra showed different relative intensities of the two...

Báo cáo khoa học: Structural and functional evidence for a singular repertoire of BMP receptor signal transducing proteins in the lophotrochozoan Crassostrea gigas suggests a shared ancestral BMP/activin pathway docx

... and the cysteine knot is boxed.Also boxed are the transmembrane domain, the ATP binding site, the L45 loop and the serine ⁄ threonine kinase domain. (B) The implied amino acid sequence of Cg-TGFbsfR2 ... C1 deﬁnes the domain closest to the amino terminal end and C2deﬁnes the domain closest to the cell membrane. Acomparison of the inferred amino acid sequence of the C1 and C2 domains reveals ... isboxed. The C1 and C2 domains appeared tobe joined by a ‘linker’ sequence. Also boxedare the transmembrane domain and the serine ⁄ threonine kinase domain. A. Herpin et al. BMP/activin pathway in...

Báo cáo khoa học: "STRUCTURE AND INTONATION IN SPOKEN LANGUAGE UNDERSTANDING*" pptx

... purposes the distinc- tion between intermediate- and intonational- phrase boundaries.) Finally, we accomplish the effect of in- terpolation of other parts of the tune by assigning the following ... propositions which constitute the topic or theme (if any) and the comment or rheme. These in 1 1The inclusion in the full grammar of further roles of type- raising in addition to the subject rule discussed ... that the speaker has in mind. The proof of this claim lies in showing that the rules of combinatory grammar can be made sensitive to intonation contour, which limit their application in spoken...

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