Báo cáo khoa học: Structure and topology of the transmembrane domain 4 of the divalent metal transporter in membrane-mimetic environments docx

... FEBS 20 04 Structure and topology of TM4 of DMT1 (Eur. J. Biochem. 271) 1951 Structure and topology of the transmembrane domain 4 of the divalent metal transporter in membrane-mimetic environments Hongyan ... Synthesis and biophysical analysis of transmembrane domains of a Saccharo- myces cerevisiae G protein-coupled receptor. Biochemistry 39...

Ngày tải lên: 16/03/2014, 16:20

... Phosphorylation of histone H3S10 by Pim1 kinase enables the recruitment of both MOF and P-TEFb via interactions involving the adaptor protein 14- 3-3 and the bromodomain pro- tein BRD4 which is recruited ... to promote GATA-1 binding to chromatin [ 244 ]. In some cases there is a clear hierar- chy in binding. Steroid receptors can bind to nucleo- somes and promote the bi...

Ngày tải lên: 14/02/2014, 18:20

... representation of the structure of the PSI domain of barley prophytepsin [25] (N-terminal domain, blue; C-terminal domain, red). (C) Model structure of the PSI domain of cardosin A based on the crystal structure ... feature of the PSI is the swap of the N- and C-terminal portions of the saposin-like domain, where the C-terminal portion of o...

Ngày tải lên: 19/02/2014, 12:20

... on the N-terminal FP, it would be of interest to compare the structure of the internal FP and i ts interaction w ith membrane bilayer, including in particular the structural in uence of proline. ... Kantchev and Ding-Kwo Chang Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China The structure and membrane interaction of the internal f...

Ngày tải lên: 19/02/2014, 16:20

... edge of the b2-strand), where it con- tacts both the invariant GXXG motif and the variable loop. Nucleic acid binding by tandem but independent KH domains – NMR structure of the KH3 and KH4 domains ... A45) is buried in and across the groove between the a1-helix and a2- helix and the b2-strand of KH1. Intimate contacts between protein and RNA continue acros...

Ngày tải lên: 07/03/2014, 05:20

... domains consist of a cen- tral six-stranded parallel b-sheet flanked by a varying number of a-helices. Residues involved in binding of the cofactor ThDP are located at the C-terminal ends of the ... ThDP in the V-conformation that brings the C2 atom of thiazo- lium in close proximity to the N4¢ atom of the pyrimidine moiety. Moreover, one of the reported str...

Ngày tải lên: 07/03/2014, 12:20

... ATP-binding subdomains, indicating a common structure of the ATP- binding sites of the two enzymes. Interestingly, five of the six cysteines of GlcNAc kinase had an equivalent cysteine in glucokinase, ... of glucokinase was used [23]. Based on the sequence align- ments of glucokinase and GlcNAc kinase and the common ATP-binding domain, the GlcNAc kinase was fitt...

Ngày tải lên: 08/03/2014, 10:20

... 600 40 96 · 768 40 96 · 10 24 70 11 NOESY 600 40 96 · 768 40 96 · 10 24 50 8 NOESY 600 40 96 · 768 40 96 · 10 24 100 8 NOESY 600 40 96 · 768 40 96 · 10 24 200 8 DQF-COSY 600 40 96 · 10 24 4096 · 10 24 – 12 4. 4 ... proteins [13] using the computer program NDEE (Spin Up, Lu ¨ nen, Germany). Owing to the high abundance of the amino acids valine, leucine and isoleucine...

Ngày tải lên: 16/03/2014, 16:20

... and the cysteine knot is boxed. Also boxed are the transmembrane domain, the ATP binding site, the L45 loop and the serine ⁄ threonine kinase domain. (B) The implied amino acid sequence of Cg- TGFbsfR2 ... C1 defines the domain closest to the amino terminal end and C2 defines the domain closest to the cell membrane. A comparison of the inferred amino acid...

Ngày tải lên: 07/03/2014, 21:20

... purposes the distinc- tion between intermediate- and intonational- phrase boundaries.) Finally, we accomplish the effect of in- terpolation of other parts of the tune by assigning the following ... propositions which constitute the topic or theme (if any) and the comment or rheme. These in 1 1The inclusion in the full grammar of further roles of type-...

Ngày tải lên: 08/03/2014, 18:20