Báo cáo khoa học: Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate potx
Báo cáo khoa học: Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate potx
... and/
or inhibition (diagram not shown).
Inhibition of substrate hydrolysis by substrate analogue
To get additional information on inhibition by excess
substrate, we analyzed the inhibition of substrate ... observed inhibition of the decarbamoy-
lation rate by high concentrations of substrate analogue
(Fig. 3). The existence of another mechanism for subs...
Tài liệu Báo cáo khoa học: Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles pptx
... a molecular model of the methyltetra-
hydrofolate-binding domain of the rat liver MetS was
constructed. In the absence of a high- resolution struc-
ture of the methyltetrahydrofolate-binding site ... cycle of cytochrome
P450 [29]. Details of the potential binding and electron
transfer events that may account for the uncompetitive
inhibition of MetS by nitrobenzothiadiazole...
Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx
... situation.
Dimerization of C-LytA
The occupation of high- affinity binding sites by choline
triggers the dimerization of C-LytA [21]. The effect of
bicyclic amines on C-LytA oligomerization was ana-
lyzed by size-exclusion ... lysis) of the cell wall is an essential
process for both cell viability and liberation of viru-
lence factors. Inhibition of autolysis by excess c...
Tài liệu Báo cáo khoa học: Inhibition of pea ferredoxin–NADP(H) reductase by Zn-ferrocyanide docx
... altered by
the presence of the inhibitor, and disrupting the electron
transfer between the flavin and the second substrate mainly
causes enzyme inhibition by Zn-ferrocyanide.
Effect of Fld on the inhibition ... Trippi, V.S. (2000) Inhibition of
wheat nitrate reductase a ctivity by zinc. B iol. Plant. 43 , 257–262.
21. Egash ira, T., Takayama, F . & Sakai, K. (2003) Inh...
Tài liệu Báo cáo khoa học: Inhibition of glyceraldehyde-3-phosphate dehydrogenase by peptide and protein peroxides generated by singlet oxygen attack docx
... that
fivefold higher concentrations of H
2
O
2
needed to be
employed to generate a similar r ate and extent of inhibition
(Fig. 4 B). Inhibition by protein-derived peroxides was
slower than that induced by ... inactivation of G APDH being metal-
ion independent, whereas inhibition of GR and LDH by
H
2
O
2
occurs most rapidly in the presence of metal ions.
It is proposed...
Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf
... level of p-Akt was increased in
PrP
C
-transfected cells. Inhibition of PrP
C
expression by RNA interference
resulted in decreased p-Akt expression. Inhibition of the PI3K/Akt path-
way by one of ... in gastric cancer is associated
with activation of the PI3K/Akt pathway. Inhibition of PI3K/Akt by
LY2940002 or Akt siRNA leads to inhibition of PrP
C
-induced drug re...
Báo cáo khoa học: Inhibition of an iron-responsive element/iron regulatory protein-1 complex by ATP binding and hydrolysis docx
... the
presence of IRE, we measured hydrolysis of
[
32
P]ATP[cP] in the presence of 0–400 ng of IRE
(Fig. 8). Compared to the amount of ATP hydrolyzed
with 400 ng of IRP alone, addition of IRE increased
the ... binding of IRP-1
to IRE, or instead facilitates dissociation of the com-
plex. Enhancement of ATP hydrolysis by IRE in the
presence of IRP-1, but absence of hydr...
Báo cáo khoa học: ` Inhibition of human ether a go-go potassium channels by 2+ Ca ⁄calmodulin binding to the cytosolic N- and C-termini potx
... in steps of 3) and C-terminal (amino-acids
480–962 in steps of 3 and amino-acids 645–895 in steps
of 2) cytosolic domains of hEAG1. Binding of
BODIPY FL-labeled hCaM in the presence of 25 lm
free ... the C-terminal domain of Ca
2+
-free CaM,
i.e. apoCaM. The activation of these channels is medi-
ated by conformational changes in the CaM ⁄ SK2 com-
plex induced by binding...
Báo cáo khoa học: Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives pdf
... or by activity in the C-terminal
domain of the full-size protein, thereby accounting for
the inhibition by ‘acarbose’ reported previously [28].
Our previous studies of the inhibitory effect of ... treatment of Type 2 diabetes [23]. In
order to examine the mechanism of action of this
class of inhibitors, 3, 5, the stereoisomers of salacinol
6, 7 [25], and the six-membered...
Báo cáo khoa học: Inhibition of the NF-jB transcriptional activity by protein kinase A pot
... assay
Transient transfection of Jurkat T-lymphocytes was
accomplished by using 5 lL of SuperFect transfection
reagent (Qiagen) per ml of culture medium and a total of
1 lg of plasmid DNA. Blank control ... subunit of NF-jB,and
measured the level of NF-jB-dependent luciferase gene
expression. Transfection of p65 alone resulted in high levels
of luciferase expression, wher...
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