... Purandare AV, Chen Z, Huynh T, Pang S, Geng J,Vaccaro W, Poss MA, Oconnell J, Nowak K & Jayar-aman L (2008) Pyrazole inhibitors of coactivator associ-ated arginine methyltransferase 1 (CARM1). ... transcription,protein and RNA subcellular localization, RNAsplicing, DNA damage repair, and signal transduction[2]. Nine PRMT family members have been clonedand characterized to date, with putative 10th and ... PRMTreaction, the use of SAM analogs is a logical strategyfor the direct inhibition of PRMTs. As a SAM analog,sinefungin can compete for SAM binding and inhibitthe activity of all SAM-dependent...