Báo cáo khoa học: The antibody to GD3 ganglioside, R24, is rapidly endocytosed and recycled to the plasma membrane via the endocytic recycling compartment ppt

... ganglioside, R24, is rapidly endocytosed and recycled to the plasma membrane via the endocytic recycling compartment Inhibitory effect of brefeldin A and monensin Ramiro Iglesias-Bartolome ´ , ... shown). Together, these results indicate that R24, once internalized, is recycled to the plasma membrane and released into the culture medium. R24...

Ngày tải lên: 16/03/2014, 13:20

... vesicle formation and endocytosis. PMA is known to bind to the C1b domain of PKC and to activate its activity. To elucidate whether activation of PKC indeed mediates mature TACE disappearance we ... implicated in the emergence of Alzheimer’s disease [21,22]. The transmem- brane protein APP is processed at first either by the a-secretase or the b-secretase leading to...

Ngày tải lên: 08/03/2014, 02:20

... disordered and not visible in the elec- tron-density map (Fig. 1). Furthermore, the c-phos- phate of dTTP is not visible in the electron-density map and a magnesium ion is only seen bound to the phosphates ... designated A and B, originating from the A and B chains in the structure. dTTP binds at the site of the protein shown previously to bind the nucleotide...

Ngày tải lên: 18/02/2014, 16:20

... with V301 being the last visible residue of this peptide. Thus, because N299 is observed in the C-terminus in an internal position, we infer that the other candidate, D306, is the target for GPI modification ... processing or cathepsin L docking and stabilization not found in other organisms. Acknowledgements The authors wish to thank the Natural Sciences and Engineering...

Ngày tải lên: 07/03/2014, 16:20

... heart and testis, is specific for AMP and seems to be involved in adenosine production during hypoxia or ischemia, because it mediates the cell response to low energy charges [2]. On the other hand, ... chromatographic a nd regu latory characteristics [ 13]. The physiological relevance of t his observation remains obscure, together with the nature (either genetic or regula- t...

Ngày tải lên: 16/03/2014, 18:20

... established on this drug was admitted to the ICU. Although we did not prospec- tively look for all missed prescriptions, standard care was for the pharmacist to review admissions and note discrepancies between ... adequately characterise the errors. The categories used here specifically describe the event and general taxonomies were considered to be too broad to provide...

Ngày tải lên: 25/10/2012, 10:39

... and tau [9,13]. This toxicity is associated with the accumulation of Ab on plasma membranes and the recruitment of tau into lipid rafts [9], where tau is phosphorylated on the putative Fyn residue ... in Ab-induced excitotoxicity [11]. Furthermore, Fyn sensitizes mice to the toxic effects of Ab [15,16], and tau is required for the Fyn-mediated and Ab-mediated synap...

Ngày tải lên: 14/02/2014, 14:20

... little is known about the signaling mecha- nisms of these type IIa RPTPs and how such signaling is regulated. One way to understand these events might be to identify the extracellular ligands of the ... basement membrane using biotinylated HB-19 peptide. Preincubation with lactoferrin and HB-19 abolishes FN3d–AP binding to muscle tissue [asterisks in (A) and (B), and...

Ngày tải lên: 19/02/2014, 05:20

... The intracellular concentration of heme is maintained by the rate of its synthesis and degrada- tion [1]. Many enzymes and their regulators are responsible for heme synthesis [1,2]. On the other hand, ... from the indicated cell lines and subjected to northern blot analysis and (B) western blot analysis. (A) Northern blot analysis. Each lane contains 15 lg total RNA. The...

Ngày tải lên: 19/02/2014, 05:20

... skin-type AFPs and the presence of antifreeze activity in skin tissues of other species has led to the hypothesis that skin-type AFPs are wide- spread ancestors of liver-type (plasma) AFPs [6,9]. Atlantic ... molecular mass and N-terminal sequence for Las-AFP is identical to the isolated plasma proteins [11]. Dusky snailfish also express the same type I AFP in skin tissue t...

Ngày tải lên: 20/02/2014, 02:22