... participates in thefunctioning of this VP16-EcR gene switch. However,the use of EcR DNA binding domain and EcRE raisesthe possibilities of endogenous steroid receptors of thehost cells binding to ... because of the inadequate understanding of molecular mecha-nisms of their function in vivo.An insect hormone receptor based gene regulatorysystem, ecdysone receptor (EcR) gene switch, is gain-ing ... nuclear receptor super-family [2] which is composed of N-terminal A ⁄ Bdomain, the DNA binding C domain, the D domain(hinge region), ligand binding E domain, and C-ter-minal F domain. EcR...