Báo cáo khoa học: Molecular dynamics of the DNA-binding domain of the papillomavirus E2 transcriptional regulator uncover differential properties for DNA target accommodation pdf

... the deformability required for the formation of the Early protein 2 C-terminal DNA- binding domain DNA complexes of var- ious types is based not only on the rigidity of the base sequences in the DNA ... Papillomavirus E2 DNA- binding domain simulations FEBS Journal 274 (2007) 2385–2395 ª 2007 The Authors Journal compilation ª 2007 FEBS 2395 Molecular d...

Ngày tải lên: 16/03/2014, 10:20

... equilibrium state. The overall conformation of the helix is of B type. Average value of the major groove width is 16.8 A ˚ for DD wt and 18.0 A ˚ for DD mut , while the average widths of the minor groove are ... of the aforementioned sequence is because of the proven efficacy of the designed PNA to down-regulate the gene expression of the mutated allelle...

Ngày tải lên: 07/03/2014, 21:20

... shear motions between the helices of the stalk coiled coil. The crystallographic analysis of the motor domain of Dictyostelium dynein provides the evidence for the structural information pathway ... disrupted coordination between the two motor domains. The results now shed light on the role of the tail for the gating mechanism. Crystal structures of the...

Ngày tải lên: 14/03/2014, 22:20

... see Fig. 3 for the amino acid sequence of CTC). These fragments show that one of the two juxtaposed Cys residues at positions 120 and 121 forms a disulfide with Cys148 and the other forms a disulfide ... proteolysis of CTC. The amino acid sequence of human CTC is in upper-case letters, and the sequence of the S-tag is in lower-case letters. The numbering refers to the...

Ngày tải lên: 07/03/2014, 05:20

... structures of LAR and CD45, another role of the D2 domain was proposed: stabilization of the D1 domain [7,22]. These interactions suggest that the D2 domains function as regulators of the activity of the ... CD45-D2 is also critical for substrate recruitment of TCR-zeta in vivo, because replacement of the membrane-distal domain of CD45 with the LAR D2 do...

Ngày tải lên: 15/03/2014, 10:20

... 4452–4463 ª 2010 The Authors Journal compilation ª 2010 FEBS 4453 the a-hydrogen of the substrate, and the other is G374, which forms the binding pocket for the branched-chain acyl moiety of substrate ... the sku phenotype. Because G376V was a novel mutation in IVD, the effect of the mutation was further investi- gated by molecular modelling. Together with the pr...

Ngày tải lên: 18/02/2014, 04:20

... from the cell body to the axon terminal in the sinus gland, as a result of late and progressive isomerization of the Phe3 of the CHH during the migration of the secretion vesicles along the axonal tract ... microscopy study of the neuronal endings in the sinus gland to determine the subcellular localization of the different epimers. Taken together, these re...

Ngày tải lên: 18/02/2014, 11:20

... that play key roles in the accumulation of inflammatory cells at the site of inflammation. There- fore, chemokines and chemokine receptors are consid- ered to be therapeutic targets in several chronic Keywords chemokine ... CCL13 enhances the proliferation of FLS [13,47]. Our group reported that the proliferation of FLS by MCP- 4 ⁄ CCL13 is dependent on activation of the ext...

Ngày tải lên: 18/02/2014, 18:20

... account for the promiscuous nature of the synthesis functions performed by the prim–pol domain and to discriminate between the functions of in vitro primase and polymerase. Another finding of our ... as RepA [18]. Bioinformatic analyses of the predicted amino acid sequence showed that the C-terminal half of the RepA of the pIT3 plasmid is sequence-similar to th...

Ngày tải lên: 18/02/2014, 18:20

... spectra of the M domain of human eRF1. The numbering of the residues corresponds to that of the full eRF1 protein. (A) The Gly region of the 1 H, 15 N-HSQC spectrum of the M domain of human eRF1 ... analysis The conformations of the backbone and side-chains of the M domain of human eRF1 are well defined except for the residues (175–189) in the...

Ngày tải lên: 07/03/2014, 05:20