Báo cáo khoa học: Hemitoxin, the first potassium channel toxin from the venom of the Iranian scorpion Hemiscorpius lepturus ppt

... 2008 The Authors Journal compilation ª 2008 FEBS Hemitoxin, the first potassium channel toxin from the venom of the Iranian scorpion Hemiscorpius lepturus Najet Srairi-Abid 1, *, Delavar Shahbazzadeh 1,2, *, ... 2008) doi:10.1111/j.1742-4658.2008.06607.x Hemitoxin (HTX) is a new K + channel blocker isolated from the venom of the Iranian scorpion...

Ngày tải lên: 16/03/2014, 06:20

... minimal. Morphological evidence of the antiapoptotic effect of HSS As shown in Fig. 2A,B, the treatment of cells with 50 lm CCCP induced profound changes in the nuclear morphology of hepatoma cells, with ... decreasing the activity of caspase-3 in the three cell lines. Effect of HSS knockdown on CCCP-induced apoptosis To further elucidate the functional role of HSS i...

Ngày tải lên: 16/02/2014, 09:20

... in the central cylinder of the root, but not in the lower parts of the hypocotyl (a). Rosette leaves were stained in the vascular tissue of the leaf blade, whereas the petiole and older parts of ... staining within the vascular tissue at the end of the leaf blade, whereas the basal parts close to the petiole remained almost unstained. We observed clear GUS ex...

Ngày tải lên: 18/02/2014, 06:20

... entirely to the catalytic role of these domains. Rather, the advantage appears to depend on the ability of the lipoyl group to protrude from the inner core of the complex, indicative of the biological ... Another essential feature of the lipoate residues within the 2-oxo acid dehydrogenase complexes arises from the ÔcrowdingÕ effect. Confinement of the com...

Ngày tải lên: 17/03/2014, 09:20

... a rich resource for the discovery of novel pharmaceutical agents. The biosyn- thesis of the oligopeptides can be either carried out via a ribosomal strategy, as in the case of capistruin or patellamide, ... regarding the chromophore moiety enables the chemoenzymatic synthesis of the quinoxaline- and quinoline-type class of chromodepsipeptides. TioS T-TE is the first...

Ngày tải lên: 23/03/2014, 06:20

... to obtain the new strains reported in Table 1. Genomic HA-tagging of SDH1 Three consecutive copies of the HA epitope were fused to the 3¢-end of the SDH1 ORF in the genome of both the WT and ... specific responsive elements in the 5¢-UTR of methionine syn- thetase mRNA [46]. Sequence analysis of the 5¢-UTR of this mRNA also reveals the presence of two upstream...

Ngày tải lên: 23/03/2014, 07:20

... tryptophans. Therefore, the shape of the near-UV CD spectra of EspA suggests the presence of some ter- tiary contacts around at least one of the tyrosines both at pH 7.0 and 2.0 (Fig. 2B). To gain further ... cm )1 which is characteristic for the intermole- Fig. 4. Sedimentation equilibrium. (A) Plot of the logarithm of the absorbance at 280 nm, A 280 , as a function...

Ngày tải lên: 30/03/2014, 16:20

... (http://www.rsb.info.nih.gov/ nih-image/), the relative fluorescence intensity of the PTPCs was determined as the intensity of the individual cells relative to the mean pixel fluorescence for the entire somata (S) of the brain. ... participa- ting in the decision to express the PTTH gene. The 5¢-upstream region of the PTTH gene from )180 to )151 is similar to th...

Ngày tải lên: 30/03/2014, 20:20

... decreasing order of frequency with which they were generated. 4.3 The generator The performances of the generator on the 10 translation sessions are reported in Table 4. The coverage of the generator ... We tuned the 8 coefficients of the so-called log-linear combination maximized at decoding time on the first 200 pairs of terms of the DEV corpora. On the D...

Ngày tải lên: 31/03/2014, 20:20

... C 5 -domain, catalyzing the intramolecular nucleophilic attack of the L-hOrn 3 a-amino group onto l-haOrn 4 . Taking into account that the synthetases involved in the bio- synthesis of the DKP-inheriting toxins ... characterization of these compounds is growing and may result in the synthesis of specific inhibitors based on the structure of the pathogen siderophore [1...

Ngày tải lên: 16/02/2014, 09:20