Báo cáo khoa học: Binding of berberine to human telomeric quadruplex – spectroscopic, calorimetric and molecular modeling studies pot
Báo cáo khoa học: Binding of berberine to human telomeric quadruplex – spectroscopic, calorimetric and molecular modeling studies pot
... quadruplex berberine interactionFEBS Journal 275 (2008) 397 1–3 983 ª 2008 The Authors Journal compilation ª 2008 FEBS 3983 Binding of berberine to human telomeric quadruplex – spectroscopic, calorimetric ... formation of intramolecularG-quadruplexes by the telomeric G-rich strand inhibitsthe activity of telomerase [10]. Therefore, ligand-induced stabilization of intramolecular telomeric G-quadruplexes ... structural details of the quadruplex berberine interaction.ResultsEquilibrium binding studies by UV-visiblespectroscopy To gain insight into the interaction between berberine and the G-quadruplex...
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Báo cáo khoa học: Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivation ppt
... affinity of Pabc forcGMP. Binding of cGMP to Pabc is not involved PDEactivation Binding of [3H]cGMP to Pabc implies that cGMP binding may be involved in the activation of P abcc to Pabc and ⁄ ... inhibitor and transducin. Kinet-ics and affinity studies. Biochemistry 32, 863 6–8 645.48 Yamazaki A, Yamazaki M, Bondarenko VA &Matsumoto H (1996) Discrimination of two functions of photoreceptor ... to prove the formation of a GTP–TaÆPabcc complex containing RGS9 and accessoryproteins and its decomposition during deactivation of GTP–Ta-activated PDE. Binding of cGMP to the noncatalytic site...
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Báo cáo khoa học: Binding of hemolin to bacterial lipopolysaccharide and lipoteichoic acid An immunoglobulin superfamily member from insects as a pattern-recognition receptor doc
... and to lipoteichoic acid from G ram-positive bacteria. Binding of hemolin to smooth-type forms of LPS was competed for efficiently by lipoteichoic acid and by rough mutant (Ra and R c) forms of ... of bacteria and yeast by hemolin may be due to binding and crossing-linking of these micro-organisms by hemolin. Binding of hemolin to bacteria and yeast cellsM. sexta hemolin was reported to ... Specific binding (demonstrated by competitionwith unlabeled hemolin) accounted f or 70% of the h emolin binding to M. lysodeikticus, 46% of the binding to E. coli, and 25% of the binding to S....
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Báo cáo khoa học: Induction of translationally controlled tumor protein (TCTP) by transcriptional and post-transcriptional mechanisms pot
... the pat-terns of protein binding to the 5¢-UTR or 3¢-UTR dif-fer significantly, although some proteins seem to bind to both; (b) the pattern of 5¢-UTR and 3¢-UTR protein binding of PMA-treated ... found to mediate these effects of cobalt and nickel. Post-transcriptional regulationwas associated with qualitative and quantitative changes in the binding of specific RNA -binding proteins to UTRs.AbbreviationsARE, ... does not differ ascompared to the control; (c) dioxin-, nickel- and cobalt-treated extracts show qualitative (appearance of new bands and suppression of control bands) and quantitative (signal...
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Báo cáo khoa học: Binding of the volatile general anesthetics halothane and isoflurane to a mammalian b-barrel protein doc
... natural ligand of bovine odorant -binding protein. J Biol Chem 276, 715 0–7 155.26 Wiseman T, Williston S, Brandts JF & Lin L-N (1989)Rapid measurement of binding constants and heats of binding ... energy of binding (D G °)exceeded the heat of binding (DH°) by more than afactor of two (Table 1), indicating that binding to por-cine odorant binding protein is entropy driven, in con-trast to ... furtherdefining a potential mechanism of volatile generalanesthetic action.Results Binding of the volatile anesthetic halothane to the hydrophobic core of porcine odorant binding proteinThe binding of halothane...
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Báo cáo khoa học: Binding of non-natural 3¢-nucleotides to ribonuclease A ppt
... Graph Model 15, 13 2–1 34.C. L. Jenkins et al. Binding of non-natural 3¢-nucleotides to RNase AFEBS Journal 272 (2005) 74 4–7 55 ª 2005 FEBS 755 Binding of non-natural 3¢-nucleotides to ribonuclease ... aside for thecalculation of Rfree[45]. The 3¢-nucleotide and water mole-cules were modelled using the 2Fo–Fc and Fo–FcSIGMAAweighted maps. The topology and parameter files for the3¢-nucleotides ... Lett28, 10 1–1 02.19 Giner J-L & Ferris WV Jr (2002) Synthesis of 2-C-methyl-d-erythritol-2,4-cyclopyrophosphate. OrgLett 4, 122 5–1 226. Binding of non-natural 3¢-nucleotides to RNase A C....
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Báo cáo khoa học: Binding of activated Factor XII to endothelial cells affects its inactivation by the C1-esterase inhibitor pptx
... disturbs the binding of FXIIa to HUVEC by binding to soluble FXIIa. (B) The C1-INH binds to receptor boundFXIIa.Fig. 4. Correlation between amidolytic activity and the amount of FXIIabound to the ... of Zn2+as a result of leakage fromdisturbed cells. This leakage may lead to binding of FXII and PKK/HK to respective receptors on endothelial cells.Localized at the site of injury, FXII and ... activity of the cell-bound FXIIa by binding to FXIIa while still bound to the cellular receptor.This mechanism was confirmed by analysing the effect of C1-INH on the kinetics of FXIIa binding to the...
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Báo cáo khoa học: Binding of the viral immunogenic octapeptide VSV8 to native glucose-regulated protein Grp94 (gp96) and its inhibition by the physiological ligands ATP and Ca2+ Ming Ying and Torgeir Flatmark pot
... (gp96) and itsinhibition by the physiological ligands ATP and Ca2+Ming Ying and Torgeir FlatmarkSection of Biochemistry and Molecular Biology, Department of Biomedicine, University of Bergen, ... affinity and low stoichio-metry of peptide binding to Grp94 in vitro, and thefinding that this binding seems to be almost irrevers-ible, have questioned the proposed in vivo peptideacceptor–donor ... which are oftenobserved on low -molecular- mass ligand binding to immobi-lized proteins [25,4 1–4 3]. To account for different immobilization levels of protein,the SPR responses to analyte binding...
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Tài liệu Báo cáo khoa học: Exposure of IgG to an acidic environment results in molecular modifications and in enhanced protective activity in sepsis doc
... concentrations of IVIg: 100 lgÆmL)1(lines 1–3 ) and 50 lgÆmL)1(lines 4–6 ). (C) Increased binding of pH 4 buffer-exposed IVIg to recombinant human IFN-c. (D) Increased binding of low-pH buffer-exposed ... recognition of the target antigen. All of these findings allow us to hypothesize that elevated binding to various molecular patterns of monoclonal and polyclonal IgG after theirtransient exposure to low ... buffer-exposed IVIg to human factor H. In both panels, binding of the native IVIg is indicated by a solid line, and that of the low-pH buffer-exposed IVIg is indicated by a dashed line. (E) Binding of twocommercially...
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Tài liệu Báo cáo khoa học: Binding of N- and C-terminal anti-prion protein antibodies generates distinct phenotypes of cellular prion proteins (PrPC) obtained from human, sheep, cattle and mouse doc
... intensities of the di- (d), mono- (j) and nonglycosylated isoform (m) of PrPCwere quantified and calcu-lated as percentages of the total signal. The glycoforms of the pro-tein bands were analyzed ... C).bLinear epitope of ovine PrP.cLinear epitope of human PrP.dRecog-nized solid-phase immobilized peptide 12 6–1 64, but failed to bind peptide 14 2–1 60 [50].Glycotyping of PrPCT. Kuczius ... at18 and 2 1–2 2 kDa, respectively [25].In the past, little attention was given to the bandingpatterns and different glycoforms of PrPC. In thisstudy, we have analyzed the glycoform patterns of PrPCof...
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