Báo cáo khoa học: Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species pptx

... regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species Hideki Sumimoto Medical Institute of Bioregulation, Kyushu University, Fukuoka CREST, Japan Science and Technology ... NH2 and NE in the side chain of this resi- due forming hydrogen bonds with oxygens of the 3-phosphate; NH1 and NH2 of Arg105 form hydrogen bonds wi...

Ngày tải lên: 16/03/2014, 06:20

... with the exception of some TAFII and NC2 and NF-Y factors that have histone fold motifs [52]. Group G is a small subset that contains all the SMAD proteins of the HTFN and APC and b-catenin-related ... that a consequence of the hierarchical component of HTFN is that not all factors in each group have the same level of relation. Unlike a simple modular network, the co...

Ngày tải lên: 19/02/2014, 07:20

... FEBS MINIREVIEW Activation, regulation, and inhibition of DYRK1A Walter Becker 1 and Wolfgang Sippl 2 1 Institute of Pharmacology and Toxicology, Medical Faculty of the RWTH Aachen University, Germany 2 Institute of ... Because the level of activity of DYRK1A is of key importance for its physiological and pathological effects, this review focuses on the molecular mechan...

Ngày tải lên: 22/03/2014, 16:21

... discussed, the presence of a comple- mentary strand of DNA disfavours G-quadruplex formation and so we may expect that G-quadruplex- J. L. Huppert Structure, location and interactions of G-quadruplexes FEBS ... hypotheses and providing proof of concept and statistical evidence for many of them. Over the next few years, it will become essential to investigate more of th...

Ngày tải lên: 23/03/2014, 03:20

... members of this superfamily may offer clues about the evolution of some metabolic pathways, and show the evolutionary history of different organisms: for example, ER was recruited from MDR and incorporated into ... from sense and antisense strands of pre-existing genes. J. Theor. Biol. 158, 271–291. 132. Skulachev, V.P. (1994) Bioenergetics: the evolution of molecular mech...

Ngày tải lên: 31/03/2014, 07:20

... Exhaustive digestion of tamXG by Xeg74 created a set of XGOs from known amounts of substrate (0–1500 lg), and the approxi- mate relationship between the glucose standard curve and the nmoles of XGOs produced ... (G4) and cellopentaose (G5). Each of the six purified T. fusca cellulases was tested for activity on tamXG and only Cel9B was active. However, it produced only two o...

Ngày tải lên: 23/03/2014, 21:20

... on these observations and RPA analysis of primary transcript levels, it appeared that the rate of transcription of the CB1 gene was decreased in the striata of R6 mice and that t his decrease led ... is the loss of cannabinoid receptors [6]. Immuno- histochemistry and r adio-ligand b inding ass ays of post- mortem human b rains at different ages and stages of HD have...

Ngày tải lên: 16/03/2014, 18:20

... the phenolate oxygen of Y51, N of G257 and NE2 of Q53 of the symmetry related subunit. Another oxygen atom is held by hydrogen bonding to NE2 of H122 and phenolate oxygen of Y51 of the symmetry related ... highlight the role of E53 in bind- ing of THF ⁄ FTHF and in the proper positioning of l-Ser for direct attack by N5 of THF. The structure of E53QbsSHMT i...

Ngày tải lên: 18/02/2014, 16:20

... courses and effects of unlabeled ligands and low pH on the dissociation rates of [ 125 I]TC-PCSK9 (A) and [ 125 I]TC-PCSK9-D374Y (B) from HepG2 cells. Binding to equilibrium and removal of unbound ... that there is a fraction of rapidly dissociating receptors,  40% after 60 min of associa- tion, that converts with time to a receptor state that releases bound ligand ve...

Ngày tải lên: 14/02/2014, 14:20

... expression of T-bet has been seen within a wide variety of tissues and cells in the Ginbuna crucian carp [27] and, in mammals, in the lung tissue of mouse and spleen and thymus of human and mouse ... TGF-b1, and it is IL-1, IL-6 and IL-23 that promote human Th17 differentiation [17]. Lastly, T reg cells are crucial players in the regulation suppression of each of t...

Ngày tải lên: 16/02/2014, 09:20