Báo cáo khoa học: Treatment with small interfering RNA affects the microRNA pathway and causes unspecific defects in zebrafish embryos doc

... Treatment with small interfering RNA affects the microRNA pathway and causes unspecific defects in zebrafish embryos Xiao-Feng Zhao, Anders Fjose, Natalia Larsen, Jon V. Helvik and Øyvind Drivenes Department ... processing as well as cleavage of dsRNA into small interfering RNAs (siRNAs). Moreover, mature miRNA and Keywords dicer; maternal mRNA; microRNA...

Ngày tải lên: 16/03/2014, 06:20

... from a document, we use sliding window techniques (Maarek et al., 1991). The window is a slide from the first word of the document to the last in the size of the window (60 words) and the interval ... similarity with the title words, we assign a word to the keyword list of a category with the maximum similarity score and recalculate the score of the wo...

Ngày tải lên: 20/02/2014, 16:20

... resulted in either an unin- tentional significant reduction in the probability of treatment being timely and effective or an unintentional significant increase in the risk of harm when compared with ... introduced the potential for bias in the results and is a limitation of the study. Medical errors are among the leading causes of death in the United States....

Ngày tải lên: 25/10/2012, 10:39

... extracted the protein coordinates and the four nucleotides bound at the center of the domain (for structures containing more than one RNA- binding domain, the structure was divided into two independent ... and do not interact with the protein [54], yet the disruption of the helix clearly affects the binding energy. The effect of these changes in RNA conformati...

Ngày tải lên: 18/02/2014, 16:20

... there is little direct evidence in the literature to confirm this link [21]. In insects, there has been a long-standing focus on Hsp70, which remains the most commonly studied stress protein in ... 0.766). Hsp70 and Hsp68 Of the 11 Hsp genes examined, Hsp70Aa and Hsp68 were the most cold-inducible, with overall expression being treatment- specific, and expression being up...

Ngày tải lên: 06/03/2014, 09:22

... lack interactions that may retain it in the ER, and (b) the protein needs to be recognized by the export machin- ery of the ER. The retention of folding intermediates can be the consequence of their ... whilst maintaining the freedom to arrange them according to the needs of the various folding clients provides the ER with the flexibility required for a dynamic and...

Ngày tải lên: 07/03/2014, 06:20

... written Chinese sentences, each sentence in the corpus was first segmented into a corresponding word string before used in the model training. Moreover, the test data include 200 sentences randomly ... following parsing strategies, both the unification grammar and the Markov language model will be integrated in the language model to obtain better results. The pars...

Ngày tải lên: 08/03/2014, 07:20

... an input, starts from the initial state with its head scanning the root node of an input. Ac- cording to the current state and the label of the scanned node, it transforms an input tree into ... p2. Intuitively, in a dc-lfg G, for each pair (tl, t2) of derivation trees in G, if the f-structure and nonterminal of the root of tl are the same as those of t2, then t...

Ngày tải lên: 08/03/2014, 07:20

... in multiple interdependent signals between pathways originating from receptor serine/threo- nine kinases and receptor tyrosine kinases. Cellular responses induced by bone morphogenetic protein (BMP) ... [21,22]. Furthermore, Smad7 was shown to interfere with signal transduction by interaction with cytoplasmic proteins such as TAB1 [61] or mitogen-activated protein kinase kinase kinase...

Ngày tải lên: 16/03/2014, 16:20

... proteins, they may represent useful targets for various therapeutic strategies. Interestingly, Clostridium perfringens entero- toxin is a ligand for CLDN3 and CLDN4 proteins, and binding of the ... prominently reported, and there is interest in developing these proteins as diagnostic and prognostic markers for this disease. In western blotting analysis, CLDN3, HLA-A1 and SLC25...

Ngày tải lên: 16/02/2014, 15:20