Báo cáo khoa học: pyr RNA binding to the Bacillus caldolyticus PyrR attenuation protein – characterization and regulation by uridine and guanosine nucleotides potx

... fibrosis and autoimmune disorders. Signa- ling is initiated by binding of the cytokine to a homodimeric complex of cytokine receptor type II, which recruits type I receptor and activates it by phos- phorylation. ... consisting of the WH domain binds DNA with nanomolar affinity and the binding is further increased by the presence of the UHM domain [44]. Because the...

Ngày tải lên: 19/02/2014, 02:20

... see, the dissimilarities among the top 30 associations to palm are all in the upper half of the scale and not very distinct. The two expected clusters for palm, one relating to its hand and the ... frond and the rest of the vocabulary. In the case of sake the beverage sense is extremely rare in the BNC and therefore was not represented among the top 30 a...

Ngày tải lên: 20/02/2014, 16:20

... on the different metals are shown in Fig. 1B. Construction of the omcA – and omcB – single mutants and of the omcA – omcB – double mutant strains of MR-1 Single omcA – and omcB – mutants and ... omcA – , omcB – and omcA – omcB – , respect- ively, indicating no upregulation or downregulation of FR (P ¼ 0.83). On the basis of the fact...

Ngày tải lên: 07/03/2014, 09:20

... cluster, and to assign the differential vector to the most appropriate other cluster. This process can be repeated until the length of the differential vector falls below a threshold or, alternatively, ... is done by computing dif- ferential vectors, and by assigning these to the most similar other cluster. Hereby for the cosine similarity we set a threshold of...

Ngày tải lên: 08/03/2014, 04:22

... bound by GST–JLP 1–1 01 and GST– JLP 2 1–1 01 deletion mutants at levels similar to those LexA NH 2 Finger Bait Prey β β –Gal – pGAD–GH pLex–hsMOK2 NH 2 LexA Finger – pLexA LexA pGAD–JLP ( 1–1 41) + /– pGAD–GH pLex–NH 2 LexA NH 2 – pGAD–GH pLex–Finger LexA Finger + /– pLex–NH 2 LexA NH 2 pGAD–JLP ... ( 1–1 41) + /– pGAD–GH pLex–NH 2 LexA NH 2 – pGAD–GH p...

Ngày tải lên: 07/03/2014, 01:20

... proteins have been found to pro- mote RNA folding: (a) specifically binding proteins, which recognize and bind certain RNAs and thus stabilize the RNA structure, thereby forming a stable RNA- protein ... StpA and RNA even further is the fact that the protein is dispensable after the refolding of an RNA molecule has occurred, and can be digested by proteinase...

Ngày tải lên: 14/02/2014, 19:20

... of the substrate struc- ture by the CBMs is considered to facilitate hydrolysis [5]. CBMs can also be involved in binding the bacterial cell wall, thereby anchoring the attached enzyme onto the ... Obviously, substrate binding is closely linked to activity. There- fore, the binding of the different XBS and XAN mutants towards water-unextractable AX and OSX was as...

Ngày tải lên: 14/02/2014, 19:20

... immunomodulatory effect of the prepara- tion [13]. To determine whether the IgG treatment described affected binding to a typical proinflammato- ry cytokine, the interactions of the native and the low-pH ... shown by us, as well as by others, that the in vitro exposure of monoclonal and of polyclonal IgG to various protein- destabilizing factors may result in dram...

Ngày tải lên: 16/02/2014, 15:20

Ngày tải lên: 18/02/2014, 03:20

... features of the inhibitors as well as to the packing constraints of the environment. The lar- ger and wider the features of the ligands that compete with the occluding loop for binding to the active ... FEBS held together by the disulfide bond between C108 and C119. Its attachment to the body of the enzyme is sta- bilized by two salt bridges, between H110...

Ngày tải lên: 18/02/2014, 04:20