Báo cáo khoa học: Structure–function relationship of novel X4 HIV-1 entry inhibitors – L- and D-arginine peptide-aminoglycoside conjugates pptx

... 274 (2007) 652 3–6 536 ª 2007 The Authors Journal compilation ª 2007 FEBS Structure–function relationship of novel X4 HIV-1 entry inhibitors – L- and D-arginine peptide-aminoglycoside conjugates Ravi ... anti -HIV-1 and mode of action of neomy- cin and neamine conjugated at specific sites to arginine 6- and 9-mers d- and l-arginine peptides (APACs)....

Ngày tải lên: 16/03/2014, 06:20

... spinalin peak was often observed at 56 0–6 30 mm NaCl. SDS ⁄ PAGE in the absence of a reducing agent showed that the spinalin of the first peak migrates as a double band in the gel, with one band running ... which, AB C D Fig. 2. Expression of spinalin in HEK293 cells and purification of the recombinant protein. Aliquots of serum-free culture medium of the cells (lanes 1) or of...

Ngày tải lên: 07/03/2014, 12:20

... residues 1–1 54, 1–2 21, 1–3 05, 15 4–2 21, 15 4–3 01 and 22 1–3 05 were pro- duced in Escherichia coli and purified to homogeneity, free of affinity tags used for increased solubility during expression and purification. ... one exception: the number of valine residues was doubled in the 1–2 21 and 1–3 05 sequences of spinophilin. Thus, the increasingly structured...

Ngày tải lên: 16/03/2014, 06:20

... specificity and potency, A10 and N11, are shown in pink and labeled. Residues 4–7 and 9–1 0 in the closely related PnIB have also been shown to influ- ence activity [38]. Ó FEBS 2004 Structures of neuronally ... in the residue type and in the case of loop 2 in both the type and number of residues. The N- and C-termini are labeled. (B) On the left is the three-dimensional...

Ngày tải lên: 19/02/2014, 12:20

... 215, 46 3–4 68. 31 Jensen RB, Grohmann E, Schwab H, Diaz_Orejas R & Gerdes K (1995) Comparison of ccd of F, parDE of RP4, and parD of R1 using a novel conditional replication control system of plasmid ... our understanding of impor- tant aspects of the autoregulation of the operon. In particular, Tsuchimoto and Ohtsubo [37] described the interaction of fusion var...

Ngày tải lên: 18/02/2014, 04:20

... UDP-glucuronosyltransferase(s). Inhibitors of b-glucuronidase and esterases did not affect the formation of glucuronate, arguing against the involvement of a glucuronidation–deglucuronidation cycle. The sensitivity of UDP-glucuronidase ... (1979) A method for the estimation of esterase synthesis and degradation and its application to evaluate the influence of insulin and...

Ngày tải lên: 19/02/2014, 07:20

... input variables and to explain the behaviour of the branch-point in terms of the kinetic properties of CGS and TS. Sensitivity analysis In a first analysis, fluxes of cystathionine and threonine (Fig. ... independent of what happens on the cystathionine side. The Phser branch-point combines the divergence of two fluxes (fluxes of cystathionine and threonine) with the converg...

Ngày tải lên: 20/02/2014, 02:21

... right-handed aglycon helix was greater than that of DDI-1B; (e) the enhancement effects of DDI-1A and DDI-1B on AAT, CAG and CA repeats are stronger than that of the ATT, CTG and GT strand, which ... than those of their complementary strands, ATT and GT (Fig. 1B,C). As such, the enhancement effects of AB CDE F Fig. 1. Expansion of the various repeats and the effect of...

Ngày tải lên: 07/03/2014, 06:20

... Language Processing and Very Large Corpora, pages 1 8–2 5. Taku Kudo and Yuji Matsumoto. 2000b. Use of support vector learning for chunk identification. In Proceed- ings of the 4th Conference on CoNLL-2000 and LLL- 2000, ... of Active Learning We use pool-based active learning (Lewis and Gale, 1994). SVMs are used here instead of probabilistic classifiers used by Lewis and G...

Ngày tải lên: 17/03/2014, 08:20

... recruitment of MOF to recently transcribed regions, especially at the 3¢ ends of genes where H3-K36me3 is enriched [128]. In mammalian cells MOF also exists as part of a sepa- rate MOF–MSLv1 complex ... with binding of both MOF and Tip60 (equivalent to Esa1 in yeast NuA4) [124,130]. However, in human cells depletion of MOF, but not Tip60, results in reduced global levels of AcH4...

Ngày tải lên: 14/02/2014, 18:20