Báo cáo khoa học: Polypyrimidine tract binding protein regulates alternative splicing of an aberrant pseudoexon in NF1 pdf

... Polypyrimidine tract binding protein regulates alternative splicing of an aberrant pseudoexon in NF1 Michela Raponi 1 , Emanuele Buratti 2 , Miriam Llorian 3 , Cristiana Stuani 2 , Christopher ... of developing therapies to turn off activated pseudoexons. Abbreviations NF1, neurofibromatosis type 1; nPTB, neuronal polypyrimidine tract binding protein; PTB,...

Ngày tải lên: 16/03/2014, 04:20

... September 2009) doi:10.1111/j.1742-4658.2009.07380.x Polypyrimidine tract- binding protein (PTB) is a widely expressed RNA- binding protein with multiple roles in RNA processing, including the splic- ing of alternative exons, ... AD, Okano HJ, Yang YY, Stefani G & Darnell RB (2000) A brain-enriched polypyrimidine tract- binding protein antagonizes the ability of...

Ngày tải lên: 07/03/2014, 00:20

... were stained with 10 lLof PI and 5 lL of annexin V–FITC, and incubated for 15 min at room temperature in the dark. The samples were brought to a volume of 800 lL with Binding Buffer, and run ... loss of both HMGN1a and HMGN2, or of only HMGN2, impairs the rate of UV- induced GGR. Loss of HMGNs leads to an increase in both the UV-induced rate of apoptosis and in the lev...

Ngày tải lên: 07/03/2014, 00:20

... properties that can result in crosslinking and misfolding. Recombinant protein production might induce aggregation and elicit stress responses Heterologous protein production is by itself cause of toxicity ... structure of aggregates can be useful to dissect pathways and bottlenecks in the folding of specific proteins, for example those containing disulfide bonds or requiring cofa...

Ngày tải lên: 06/03/2014, 00:20

... slower-migrating DNA protein complexes in a dose-dependent manner (lanes 4 and 5), whereas the control GST protein alone did not form DNA protein complexes (lanes 2 and 3). The presence of Nrl in the protein DNA ... functions, including a mitotic checkpoint in Xenopus laevis and binding to APC pro- tein, which acts as a scaffold for b-catenin, axin and glycogen synthase kinase-...

Ngày tải lên: 06/03/2014, 02:20

... negative balance in the ratio between protein syn- thesis and protein degradation, hence leading towards protein wasting. One of the key players in the degrada- tion of myofibrillar proteins is the ... repeat protein (CARP) was suggested to be involved in these pro- cesses. CARP, together with ankyrin repeat domain- containing protein 2 (Ankrd2) and diabetes-related ankyrin...

Ngày tải lên: 07/03/2014, 03:20

... several ARE binding proteins, including the stabilizing protein HuR [86] and the mRNA destabilizing protein tristetr- aprolin (TTP) [87]. HuR is a member of the Hu family of mRNA binding proteins and has ... eosinophil-specific granules and shown to be still capable of inhibiting urokinase. It was suggested that PAI-2 might play a role in eosinophil mediated in am- mation and...

Ngày tải lên: 20/02/2014, 02:21

... of the fluency problem in English-Hindi SMT Ananthakrishnan Ramanathan, Hansraj Choudhary Avishek Ghosh, Pushpak Bhattacharyya Department of Computer Science and Engineering Indian Institute of ... create Hindi language models using the target side of the train- ing corpus. Training, tuning, and decoding were performed using the Moses toolkit 3 . Tuning (learning the λ values discuss...

Ngày tải lên: 08/03/2014, 00:20

... mother. An in- teresting trait of PLIG is that it can generate the language {w k |w is in a regular language and k ∈ N }. This is similar to the pattern of SVC in which a series of verb phrase can ... Chinese and Thai, whose degree of pro-dropping is more free. In this paper, I explain how we can deal with serial verb construction with CCG by incorpo- rating memory mechanism...

Ngày tải lên: 08/03/2014, 21:20

... BCR–ABL and pan- aurora kinase inhibitor MK-0457, which can inhibit both wild-type and imatinib-resistant BCR–ABL mutants (including T315I). Despite inhibiting BCR– ABL, MK-0457 predominantly induces ... including the repression or inhibition of BIM. Arising from this is a growing understanding of (a) the role that these pathways play in repressing BIM and in promoting aberrant cell...

Ngày tải lên: 16/03/2014, 00:20