... B E B B B Domain B B B B B A B A B E B B A B B B B E b – – 31 34 38 43 47 57 62 67 76 81 – 13 17 b 2 10 21 – c 32 35 39 44 48 50 53 58 63 68 72 77 82 25 14 18 22 c 3 6 28 f 36 41 45 49 51 54 59 64 69 73 78 83 26 15 19 24 e 4 7 29 – 40 – – – – – – – – – – – – – – 23 d – – – L-Glyceraldehyde a – – 30 33 37 42 46 56 61...
Ngày tải lên: 16/03/2014, 04:20
... any effect in any of the genes at the mRNA level (Fig. 4C, lane 2). RSCL-0409 blocks nuclear translocation of NF-jB and activation of NF-jB transcription factor LPS, together with a range of inflammatory ... (double-stranded RNA, single- stranded RNA and DNA) [1]. One of the prominent signalling mechanisms activated through TLRs is via LPS. LPS, the predominant structural component...
Ngày tải lên: 22/03/2014, 21:20
Báo cáo khoa học: Mechanistic studies on bovine cytosolic 5¢-nucleotidase II, an enzyme belonging to the HAD superfamily doc
... regula- tive) of the mechanisms generating these species. Moreover, cN-II presents both phosphatase and phosphotransferase activities. Even though the physiological re levance of the phosphotransferase ... reaction mechanism. J. Biol. Chem. 273, 1503 5–1 5044. 38. Wang, W., Kim, R., Jancarik, J., Yokota, K. & Kim, S.H. (2001) Crystal structure of phosphoserine phosphatase from Met...
Ngày tải lên: 16/03/2014, 18:20
Báo cáo khoa học: Cofactor-independent oxygenation reactions catalyzed by soluble methane monooxygenase at the surface of a modified gold electrode pot
... investigate the effects of catalase, MMOB and MMOB tru and the substrate acetonitrile on electron transfer to MMOH was also performed between 0 and )0.6 V, at the scan speed and protein and substrate concentrations ... contacting the electrodes was ventilated by means of a stream of air from an electric fan. The effect of the substrate methane on the electrochemical properties of...
Ngày tải lên: 17/03/2014, 09:20
Báo cáo khoa học: Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart potx
... other transporters (voltage- dependent anion channel, tricarboxylate, 2-oxoglutarate and phosphate carriers). These membrane proteins were identified by nanoLC-MS ⁄ MS in bands 8 and 9 of Fig. ... OGDHC and the membrane fraction deserves attention in view of the developing concept of membrane-including microdo- mains, which can be organized and scaffolded by olig- omeric proteins [5 4–5...
Ngày tải lên: 23/03/2014, 06:20
Tài liệu Báo cáo khoa học: Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression ppt
... configuration of the nGAAn units and can regulate the transcription of various genes that func- tion not only in stress resistance, but also in a broad range of biological processes. Mammalian cells ... Multiple inverted repeats of nGAAn found at the promoter regions of many HSP genes provide high affinity-bind- ing sites for HSF. The DBD–DBD interaction is important in the HSF–HSF an...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner pptx
... adduct of the anticancer drug cisplatin. Nature 377, 64 9–6 52. 29 Zlatanova J, Yaneva J & Leuba SH (1998) Proteins that specifically recognize cisplatin-damaged DNA: a clue to anticancer activity ... comprises about 50% of 1,2-GG IACs, 25% of 1,2-AG IACs, 10% of 1,3-GNG IACs and interstrand crosslinks, and another 2–3 % of monofunctional adducts. It has been found that cisp...
Ngày tải lên: 19/02/2014, 05:20
Tài liệu Báo cáo khoa học: Novel aggregate formation of a frame-shift mutant protein of tissue-nonspecific alkaline phosphatase is ascribed to three cysteine residues in the C-terminal extension pdf
... for 30 min and chased for 0 h (lanes 1 and 4), 3 h (lanes 2 and 5) or 6 h (lanes 3 and 6) in the absence (lanes 1–3 ) or presence of 50 l M LLnL (lanes 4–6 ). The immune complexes were analysed by ... transcription ⁄ translation. (A) Transcription-coupled translation of TNSALP or TNSALP (1559delT) were carried out in the absence (lanes 1 and 4) or presence (lanes 2, 3, 5 and 6) of c...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: "A Unified Syntactic Model for Parsing Fluent and Disfluent Speech∗" ppt
... Denver on Friday , there is an exact match of the word ‘to’ between reparandum and re- pair, and a part of speech match between the words ‘Boston’ and ‘Denver’. Another sort of structure in repair ... here follows that of Shriberg (1994). A speech repair consists of a reparandum, an interruption point, and the alter- ation. The reparandum contains the words that the speaker mean...
Ngày tải lên: 20/02/2014, 09:20
Báo cáo khoa học: Novel repressor of the human FMR1 gene ) identification ¨ of p56 human (GCC)n-binding protein as a Kruppel-like transcription factor ZF5 ppt
... mechanisms and significance in human disease. Trends Biochem Sci 22, 43 2–4 36. 3 Ashley CTJ & Warren ST (1995) Trinucleotide repeat expansion and human disease. Annu Rev Genet 29, 70 3–7 28. 4 Mangel ... content analysis of the core promoter regions of human genes revealed the presence of ZF5 consensus sites within approximately 60% of human gene core promoters [31]. In spite...
Ngày tải lên: 07/03/2014, 05:20