Báo cáo khoa học: Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain pdf

... Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain Potential substrates and/or inhibitors of Ap 4 A hydrolases Andrzej ... to understand their biological functions has been through the use of Np n N¢ analogs. Here, we present the results of studies using novel diadenosine polyphosphate analogs, w...

Ngày tải lên: 16/03/2014, 04:20

... enrichment in iNOS activity within the particulate fraction of epithelial cells. Apical distribution of iNOS in intestinal epithelial cells To get more insight into the localization of iNOS in intestinal ... of iNOS to apical domains of intestinal epithe- lial cells. Particulate fraction association of iNOS in vivo In order to determine the distribution of iNOS in intestinal...

Ngày tải lên: 19/02/2014, 16:20

... Proper Noun resulting from missing entries in the Buckwalter’s lexicon. The remaining case was a failure in the conversion process relating to the handling of bro- ken plurals at the lexeme level. ... at all. In Arabic nouns, arguably the gender feature is the more inter- esting distinction (rather than the number feature) as verbs in Arabic always agree with their n...

Ngày tải lên: 20/02/2014, 15:20

... two termini of the inserted Ca 2+ -binding sites in the model structure of the EF-hand of STIM1 is within 15 A ˚ . Accordingly, a total of six glycine linkers is suffi- cient to enable the grafted ... Ca 2+ -coordinating residues in positions 1 and 3 of the EF-hand motif significantly compromised the metal-binding capability of the engi- neered protein, indicating that the m...

Ngày tải lên: 07/03/2014, 00:20

... throughout the dynamics in DD wt leading to an uninterrupted stacking at the steps flank- ing the mismatch. The difference in the A C mismatch hydrogen bond may therefore be attributed to the signi- ficant ... absence. These, in turn, bring about dynamic water interactions in the vicinity of the mismatch. Enthalpy loss and the disproportionate entropy gain associ- ated...

Ngày tải lên: 07/03/2014, 21:20

... PtdIns(5)P, PtdIns(3,4)P 2 and PtdIns(3,5)P 2 with the strongest binding to PtdIns(5)P (Fig. 1). The ORD domain showed a very similar lipid binding pattern as the full- length protein. While the ... staining in- creased, and finally punctate staining was almost lost with predominant vacuolar staining at 30 min. Com- pared with wildtype, no delay of FM4-64 transport was observed...

Ngày tải lên: 07/03/2014, 21:20

... feature indicating the number of indefinite NPs that can be uniquely resolved in the Information State (#uniqueIndefinites, e.g. “a tower” where there is only one tower in the do- main). We include these ... TiMBL with all possible parameter set- tings on the generated training and test sets and store the best performing settings. 4. Classify the left-out hypotheses with th...

Ngày tải lên: 08/03/2014, 04:22

... Compar- ing linguistic features for modeling learning in com- puter tutoring. In Proceedings of the 2007 confer- ence on Artificial Intelligence in Education: Build- ing Technology Rich Learning Contexts ... use them for predicting the learning gain that a student could achieve when interacting with a new version of the interpretation compo- nent for the system, not yet tested...

Ngày tải lên: 08/03/2014, 21:20

... side -chain of methi- onine decreases in these two enzymes both the K m for NMP and the k cat compared with the parent molecules [16,18]. In conclusion, the amino acids interacting with the phosphate ... to the N3 atom of cytosine. As the main chain carbonyl of D129, a H-bond acceptor, interacts with the terminal oxygen of S36 side chain, the latter can only...

Ngày tải lên: 16/03/2014, 10:20

... its S 1 ¢ binding subsite. Substrate binding induces conformational changes involving the ArgA145- PheA146 fragment of the protein chain, acting as a flap, first opening and then closing the groove ... follows: Ne with the O atom of the main chain CO group of the TrpB240; Ng 1 shares H bonding with O atom of the CO group of LeuB387 together with O atom of c-OH of SerB386;...

Ngày tải lên: 16/03/2014, 16:20