Báo cáo khoa học: The use of synthetic linear tetrapyrroles to probe the verdin sites of human biliverdin-IXa reductase and human biliverdin-IXb reductase potx

... The use of synthetic linear tetrapyrroles to probe the verdin sites of human biliverdin-IXa reductase and human biliverdin-IXb reductase Edward M. Franklin 1 , ... elevating the concentration of cytosolic biliverdin-IXa. The pau- city of information on the biliverdin binding site has hampered the development of inhibitors of BVR-A. With t...

Ngày tải lên: 16/03/2014, 02:20

... 1 and 2) validates the use of selective inhibitors as convenient tools to study the spe- cificity of the somatic form of ACE. Thus, with this approach, the catalytic property of each domain towards ... with the N-domain of the mouse and human enzymes, may in part be due to this mutation. The resolution of the 3D structure of the germinal form of AC...

Ngày tải lên: 16/03/2014, 13:20

... soluble forms of the receptor [25,26,34], indicates that the ectodomain of the receptor is capable of dimer forma- tion in the absence of ligand. Affinity cross-linking of [ 125 I]IGF-II to a mutant repeat ... a local effect because binding of PMP-BSA, which binds to other sites in the ectodomain of these heterodimers, resulted in the predicted amount of ligan...

Ngày tải lên: 18/02/2014, 08:20

... cleavages in the center of the protein to form additional loose ends to be denatured out of the ball of spaghetti. The ESI spectrum of the 200 kDa human comple- ment C4 glycoprotein (of 1714 residues ... been found to be specific and potent HAD inhibitors. To check for covalent modifications of the enzyme, the effect of the inhibitor on the molecular m...

Ngày tải lên: 18/02/2014, 16:20

... into human cells may affect the metabolism of the target cells in more ways than just the therapeutic purpose of the introduced gene. The normal function of nucleoside kinases is to provide the ... previous reports. One of the most important differences may be the cell type used in the different studies. The toxicity of nucleosides, as well as the sensitivi...

Ngày tải lên: 20/02/2014, 01:20

... brother of the parent 0.2505 1.5603 0.6145 5.2 The analysis to the influence of the structural relation and the structural distance to the predictive information quantities of the history feature ... Conclusion Either of the predictive information quantity of the first word and the second word in the objective word sequence is larger than that of th...

Ngày tải lên: 20/02/2014, 18:20

... between the C tails of b and c and the ubiquitin ligase Nedd4. The WW domains of Nedd4 bind to the proline-rich PY motifs of b and cENaC, leading to channel ubiquitination, internalization and degradation ... quantified by phosphorimaging of the band corresponding to the full- length protein, and normalizing to the Coomassie blue staining of the same...

Ngày tải lên: 21/02/2014, 03:20

... positively charged nitrogen atoms of NMTIQ and MPTP and the backbone oxygen of Ser324. The dis- tances between the nitrogen atoms and the oxygen of Ser324 were 2.01 A ˚ for NMTIQ and 2.26 A ˚ for MPTP, ... to produce a major effect on neurotransmitter synthesis. In comparison, up to 10 4 -fold higher concentrations of TIQs are required to cause cytotoxic blockade...

Ngày tải lên: 07/03/2014, 05:20

... further evidence for the role of PPARc in the regulation of TP gene expression within the vasculature and point to further critical differences into the modes of regulation of TPa and TPb in humans. ... 15d-PGJ 2 -suppression of Prm3 activity. On the other hand, either deletion of the PPARc (b) and RXR IV half sites, such as in the )154 subfragment, or site-...

Ngày tải lên: 07/03/2014, 21:20

... group in the other legionaminic acid residues of the OPS. The proton signals of the major higher-®eld pair at d H 3.03 and 2.95 correlated in the 1 H, 13 CHMBCspectrumto different nonprotonated ... between the LPS of wild-type R C1 and phase variant 811 [ 24] or between the L PS of the avirulent wild-type 5097 and the corresponding mutant 137 [17]. As the mAb...

Ngày tải lên: 08/03/2014, 10:20