Báo cáo khoa học: Lysosomal localization of GLUT8 in the testis – the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction docx
Tài liệu Báo cáo khoa học: Restricted localization of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase at the neuromuscular junctions – contribution and expression from motor neurons doc
... reduc- tion of G 1 and G 4 forms in the spinal cord and of G 1 , G 4 and A 12 forms in the tibialis (Fig. 8C). Thus, denervation induced a decrease in PRiMA and G 4 AChE in the spinal cord and muscle. To ... determine the local- ization of PRiMA-linked G 4 AChE, sections of tibialis muscle were triple stained for PRiMA, SV48 and AChR. The staining of...
Ngày tải lên: 18/02/2014, 08:20
Báo cáo khoa học: Nuclear localization of human spermine oxidase isoforms – possible implications in drug response and disease etiology pptx
... both the internal region of exon V that is absent from the inactive PAOh4 isoform, as well as exon VIa, which is absent from the active isoform, SMO ⁄ PAOh1. SMO5 and the active, mouse isoform, ... components of the FAD-binding domain, and are therefore essential for catalysis [28,3 3–3 5]. Kinetic properties of SMO5 Polyamine oxidase activity of SMO5 and SMO...
Ngày tải lên: 07/03/2014, 05:20
Tài liệu Báo cáo khoa học: Erythrochelin – a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea docx
... attack of the L-hOrn 3 a-amino group onto l-haOrn 4 . Taking into account that the synthetases involved in the bio- synthesis of the DKP-inheriting toxins thaxtomin and fumitremorgin also contain ... characterization of these compounds is growing and may result in the synthesis of specific inhibitors based on the structure of the pathogen siderophore [16]. A p...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Top-down MS, a powerful complement to the high capabilities of proteolysis proteomics pdf
... Bottom-up proteolysis destroys the information on the size of the protein and the connectivities of the pep- tide fragments, but it has no size limit for protein digestion. In contrast, the top-down ... iso- topically labeling the proteins from one and compar- ing in their mixture the corresponding peaks of their respective peptides, usually differing by three...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Poly(silicate)-metabolizing silicatein in siliceous spicules and silicasomes of demosponges comprises dual enzymatic activities (silica polymerase and silica esterase) doc
... outline of the localization and transport of silicatein in the extraspi- cular space is given in Fig. 6. The data summarized here provide, for the first time, enzyme kinetic data for silicatein, ... bonds, the concentration of the released product p-aminophenol was determined at a wavelength of 300 nm, which is in the trailing edge of the main absorp...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
... P2Y 12 - dependent part of the Ca 2+ response, indicating that PI3-Kß is the main isoform in Ca 2+ signal modulation via P2Y 12 . Examination of targets downstream of AC BD Fig. 10. PI3-K ß-isoform mediates ... considerable amount of the PIP 3 formed in plate- lets [21], this may suggest that the PIP 3 produced by this isoform leads to plasma membrane binding and, he...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Tryptophan tryptophylquinone cofactor biogenesis in the aromatic amine dehydrogenase of Alcaligenes faecalis Cofactor assembly and catalytic properties of recombinant enzyme expressed in Paracoccus denitrificans pptx
... masses of the mature form of the subunits (14 472 and 40 421 Da for the small and large subunits, respectively). (The published nucleotide sequence for the aau B gene is incorrect [7]. The predicted ... biogenesis genes from the mau gene cluster. By performing detailed kinetic studies of both AADH enzymes, we show that the recombinant enzyme is indistinguishab...
Ngày tải lên: 19/02/2014, 07:20
Tài liệu Báo cáo khoa học: Mammalian mitotic centromere-associated kinesin (MCAK) A new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents pptx
... the direction of walking on micro- tubules. MCAK belongs to the Kin I subfamily and its motor domain, unlike most kinesins, is in the interior of the protein. Moreover, the protein localizes at ... binding. The tightness of binding may determine the degree of inhibition. SQAGs inhibit the depolymerization activity of MCAK in vivo To elucidate the MT-depol...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis doc
... the wild-type level and above. Fig. 1. Glycolysis and the las operon in Lactococcus lactis .The las operon in L. lactis consists of the three genes pfk, pyk and ldh, coding for phosphofructokinase ... all the genes involved in the pathway in the same operon; the cell can then respond quickly to changes in the environ- ment by changing the expression of...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: Moult cycle-related changes in biological activity of moult-inhibiting hormone (MIH) and crustacean hyperglycaemic hormone (CHH) in the crab, Carcinus maenas From target to transcript ppt
... during intermoult and premoult. The results show that the most important level of moult control lies within the signalling machinery of the target tissue, that expression and biosynthesis of ... MIH and CHH during precisely timed stages of the moult cycle of Carcinus to determine changes in: (a) potency of these peptides in repressing ecdysteroid synthesis; (b)...
Ngày tải lên: 21/02/2014, 00:20