Báo cáo khoa học: Untangling the folding mechanism of the 52-knotted protein UCH-L3 potx

... respectively, of that of HPRT. This low activity could be explained by the fact that PRTFDC1 has a Gly in the position of the proposed catalytic Asp of HPRT. In PRTFDC1, a water molecule at the position of ... and regulators of other enzymes in the human nucleotide metabolism (Table S1). The library can then be seen to constitute the specific metabolome of the nuc...

Ngày tải lên: 15/02/2014, 01:20

... whether these cytokines are produced by CD4 + CD25 + Foxp3 + T reg or whether they induce the production of these cytokines from another population of cells [20]. To date, our knowledge about the ... to be protein domains impor- tant in the functioning of these transcription factors. The gene organiza- tions of zebrafish t-bet and foxp3 were identical to those of the huma...

Ngày tải lên: 16/02/2014, 09:20

... Kessler Department of Clinical Medicine, University of Oxford, UK Introduction The genus Yersinia consists of three pathogenic species that are agents of a variety of diseases, one of which was historically the ... essential for Yersinia pathogenesis [19]. The Rho family of small G proteins represents a large group of the Ras superfamily of GTPases. More than 20 prot...

Ngày tải lên: 16/02/2014, 15:20

... respectively. Although the over- all number of these modifications is low, the density of modifications is much the same as in the rest of the lin- ker histones. It is the shortness of the N-terminal tails Table ... histones Historically, the location of the globular domain of the linker histone has been a matter of contention [13]. Currently, although there is...

Ngày tải lên: 18/02/2014, 08:20

... involved in the regulation of genes participating in cholesterol biosynthesis and low-density lipoprotein receptor synthesis [1,2]. They are now estab- lished as global regulators of lipid synthesis. ... functions. The gene encoding the cyclin-depen- dent kinase inhibitor p21 is a target gene of SREBP [20]. This finding suggests that the regulation of lipid synthesis is linked...

Ngày tải lên: 18/02/2014, 13:20

... centrifugation of the samples, proteins bound to liposomes were analyzed by SDS ⁄ PAGE of the resulting pellets. (C) The amounts of I C in the pellets. The amounts of I C were quantitated with the UN-SCAN-IT ... phospholipid and membrane binding of the other members of the PEBP family. Consequently, the binding characteristics of PEBP proteins, including those...

Ngày tải lên: 19/02/2014, 05:20

... and phylogeny. How- ever, the nature of the connections between these factors needs to be understood at the level of the pro- tein domain. The global properties of the HTFN topology are partially ... of interacting proteins responsible for the control of gene expression. They interact with DNA regions and tend to form transcriptional regulatory complexes. Thus, the fi...

Ngày tải lên: 19/02/2014, 07:20

... change in fluidity of fungal membranes may be explained by the insertion of the protein and modulation of the lat- eral pressure, as has been reported for other proteins [41]. Moreover, these results ... different types of cell, including animal, bacterial and fungal. The aim of this study was to obtain information on the cell targets and the mechanism of action of...

Ngày tải lên: 19/02/2014, 07:20

... polarized light, respectively. The bottom panel displays the result of deconvolution of the IR absorption spectrum of the peptide f or analysis of the sec ondary struc ture. The dominant pe ak at 1655 ... target cells [6,7]. A proline is often found near the centre of many of the viral IFP sequences [1]. Delos et al. [8] have shown that the central proline of...

Ngày tải lên: 19/02/2014, 16:20

... by the cons program from the emboss package. A hydrophobicity plot was generated to verify the structural similarities of the proteins. It was based on the multiple sequence alignment of the ... suggest- ing that the origin of these forms dates back to before the occurrence of vertebrates, i.e. more than 500 mya. This dates the differentiation of the MAPEG forms...

Ngày tải lên: 19/02/2014, 17:20