... Ôsticky patchesÕon the protein surface that may lead to protein aggregation[16]. In addition, introduction of a single tyrosine intothe N-terminal region has been reported to improve thethermostability ... Nussinov, R. (2000) Factors enhancingprotein thermostability. Protein Eng. 13, 179–191.39. Turunen, O., Vuorio, M., Fenel, F. & Leisola, M. (2002)Engineering of multiple arginines into ... theglycerol appears to mimic the binding of the xylose ring in the active site. The binding of glycerol to a single site maysuggest that this site is the strongest binding subsite for thexylose...