... diseases The depletion ofthe CD4 T lymphocytes is the hallmark ofthe progression of HIV infection and, in the absence of antiviral treatment, the main contributor tothe development of opportunistic ... affinity to gp120 complexed to CD4, as compared to (R5-coreceptor restricted) gp120 only The affinities ofthe antigen-antibody interactions are proportional tothe thickness ofthe arrow pointing to ... generation of cryptic epitopes and tothe activation of T cells not previously deleted by central tolerance during the maturation ofthe T cell repertoire An alternatively, not mutually exclusive hypothesis...
... restricted to a few epitopes but later spread to include other epitopes Eventually, the antibody response of both rat strains was narrowed down tothe epitopes 31 to 46, 211 to 226 and 349 to 364 of ... with those at the onset of or the peak phase ofthe disease The cytokine response to Rhsp65 was found to be similar to that against Bhsp65 [20] In general, the cytokine response of T cells against ... protein after the onset of AA downmodulates the course of AA, highlighting the significance ofthe role of this chemokine in the progression ofthe disease [19] For the T cells, the precise target...
... above the umbilicus The SAAT was defined as the thickness between the skin-fat interface and the linea alba, and the VAT was defined as the distance between the anterior wall ofthe aorta and the ... HOMA was well correlated to severity of HS and tothe spleen size, both evaluated at US The HS score was different in the two groups, so the MS detection The main inflammatory index (CRP) and SLD ... adipose tissue stores are full, we were not able to confirm this point Being IR not related tothe entity of fat deposition, we hypothesize that the chain of events does not presuppose the obesity...
... a role in the reduction ofantibioticresistanceThe duration of time that the serum drug concentration remains above the minimum inhibitory concentration ofthe 461 Critical Care October 2005 ... restrictions Restricted use of specific antibiotics or antibioticclasses from the hospital formulary has been employed as a strategy to reduce the occurrence ofantibioticresistance and antimicrobial ... an attempt to limit bacterial resistancetothe cycled antimicrobial agents This offers the potential for antibioticclassesto be used that possess greater overall activity against the predominant...
... protease-inhibitor complexes ofthe last 100 ps ofthe simulations were used, superimposing backbone Cα atoms On the basis of these structures, the conformations ofthe residues in the binding pocket and the ... protein and the T54S mutant structure The side chains ofthe residues H57 and S139 in the wild-type structure extend out ofthe surface ofthe mutant structure One ofthe hydroxyl groups ofthe SCH ... atom ofthe wild-type V36 point towards the aromatic ring of F43 The second Cγ carbon of V36 is engaged in van der Waals interactions with the aromatic ring of F43 There is no equivalent to the...
... Duration of ICU stay before VAP Duration of stay 0.04 54 (42 to 66) 0.0001 (6 to 10) 10 (6 to 18) SOFA 0.20 (5 to 10) 45 (36 to 53) SAPS II (9) (4 to 8) LOD (6 to 11) (5 to 18) 0.03 0.13 32 (20 to ... resistant to several antimicrobial agents, P aeruginosa often acquires mechanismsofresistanceto other antibiotics, especially in ICU patients This increasing antibioticresistance makes the treatment ... evaluated the impact on the outcome of a monotherapy or a combined therapy in patients with PA-VAP They showed that the initial use of a combination therapy significantly reduced the likelihood of inappropriate...
... the same subject is susceptible of being treated in many ways When the idea occurred to me of offering tothe public of Canada a history ofthe province, I was not ignorant ofthe existence of ... thousand pages of foolscap and brought to a conclusion the first rebellion Then the work of printing was begun, and the correction of all the proofs together with the editorial management of a newspaper, ... constitutes the Arctic highlands, and from which the rivers running tothe northward into Hudson's Bay, and tothe southward into the great lakes and the St Lawrence, take their riseThe icy breath of the...
... administer to their clients The effect of such antibiotic- laced concoctions would be to accumulate in the system ofthe recipients at sub-therapeutic doses, increasing the chances ofresistance ... curbing the menace of AMR is the media The trained media professionals can help to adequately convey information not only about the effects ofantibiotic misuse tothe individual, but also about the ... once on the road to recovery discard medicines without any knowledge ofthe grave danger to which they expose themselves, their families and communities The media will be the best channel of such...
... Impact ofthe Impact Factor Changing attitudes towards scientific publication must be examined in tandem with the changing role ofthe impact factor in assessing the merits of a body of work and the ... contributed tothe study design and performed the literature review for the assessment ofthe vocabulary employed and performed the analysis ofthe data She prepared the first draft ofthe manuscript ... and the impact factor has taken on a life of its own Several detailed critiques ofthe impact factor have been published [2], highlighting shortcomings such as the limitations ofthe impact factor...
... studies that attempt to isolate the specific impact ofresistance on outcome of infection cannot so divorced from consideration ofthe effect ofthe therapy received In addition to assessing delay ... institution of therapy, analysis ofthe effect of appropriateness of therapy must take into account such issues as tissue penetration, pharmacokinetic and pharmacodynamic properties ofthe agent ... correctness of dosing and intervals of administration The outcomes study by Depuydt and colleagues, like others before it, addresses the question ofthe impact ofresistance without dissecting fully the...
... amoxicillin or respiratory fluoroquinolon Antibiotic ( cont ) moderate severity admitted CAP oral antibiotic s are effective in most of cases - Amoxicillin + macrolide is the first choise - Altenative ... Masterton RG et al J Antimicrob Chemother 2008;62:5-34 Asian HAP Working Group Am J Infect Control 2008;36:S83-92 HCAP , HAP Guidelines VN guidelines for the management of lower respiratory infections ... Kông 0.50 1.00 High Prevalence of Antimicrobial Resistance among Clinical Streptococcus pneumoniae Isolates in Asia (an ANSORP Study) ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, June 2004, p 2101–2107...
... demonstrated the use of an additional separate field plate to increase the device performance from W/mm to 18.8 W/mm The improvement in the performance was due tothe reduction ofthe peak field at the ... based alloyed contacts was found to correspond tothe formation of TiN at the metal-semiconductor interface and the formation of its inclusions down tothe level ofthe 2DEG after a high temperature ... STUDY ON THE REDUCTION OF ACCESS RESISTANCEOF INALN/GAN HIGH ELECTRON MOBILITY TRANSISTORS LIU YI (M Eng., HIT) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ELECTRICAL...
... expected to send a representative to these events The representatives would then return to their church to preach the message of God tothe believers of their church Many Koreans thus found their ... helped to spread the message of God to their fellow Koreans in Korea, they also helped in the translation ofthe Bible into hangul and later “smuggled copies ofthe Bible into Korea.”24 After the ... useful insight into the role ofthe state, the repressive measures the state undertook and doctrines which the government tries to instill into the Koreans in order to help them shape new identities...
... would contribute tothe diversity of modes of action controlling B cinerea Due tothe emergence and development ofresistanceto „single-site‟ fungicides of all chemical classes, a resistance management ... the infestation of their plants with B cinerea The choice of variety is one ofthe most important factors in the control of B cinerea Resistanceof mature berries is mostly due to morphological ... conducted in the last decades, knowledge about the biology ofthe pathogen was used to decrease the number of applications to two to four sprays (BROOME et al 1995) Applications at the end of flowering...
... are indication of a right insert The remaining lanes showed only single bands these may due tothe size of insert equals tothe size of vector or the vector was self ligated For the higher size ... LB broth with the various concentrations of each of antibiotics The lowest concentration ofantibiotic at which E.coli DH5/pUC19 does not growth is defined as a MIC Extraction of total DNA from ... then inserted into the same restriction enzymes sites (multicloning sites) of pUC19 The ligated mixture was transformed into E.coli DH5α host cell and plated onto LB-Amp agar for numeration of...
... Autonomy and Imperial Power in Bartolus of Saxoferrato: An Intrinsic Connection’ (2004) 65 Journal ofthe History of Ideas 369–81 131 Territorial law and theriseofthe state city rule by the ... not the King ofthe Franks (the people) He then stood ‘in the same relation tothe soil of France as the baron to his estate, the tenant to his freehold’ This person who had started as the feudal ... more on their social position’.29 The Schöffen had to rely upon the learned clerk ofthe city to cope with the submissions ofthe legal professionals who practised the ‘learned law’ ofthe ius...
... rNetPhotosynthesis ÀrCO2 !Starch Ratesof net photosynthesis (rNetPhotosynthesis) were calculated as the average rate of carbon uptake during the first half ofthe light phase (n = h): n R rNetPhotosynthesis ... trajectory of interconversion rates as a function of time of cold exposure, (b) comparison ofthe magnitudes ofthe various interconversion rates, and (c) lineup ofthe accessions with respect to their ... derivative of this function The flux rate of CO2 into sucrose synthesis (rCO2 !Suc ) was caclulated as the difference between the rate of net photosynthesis and that of net starch synthesis (unit: C6 h)1Æg)1...
... dangerous to excellent The effect of a career decrease in training hours of 10 percent led to a 10 percent increase in the number of unsatisfactory landings, from 14 percent to 24 percent ofthe total, ... NEWCREW to define the percentage of personnel with less than one year in the Navy; and TIME_CO to be the number of months that the ship’s commanding officer has had command ofthe ship The authors ... recruits In their model, the cost of new recruits is equal tothe recruiting cost, the salaries of instructors, the costs associated with Permanent Change of Stations (PCS), and the costs of paying...
... seeking to modernize their own society according tothe Western model Smith, as the father ofthe modern social science of economics, was naturally understood to be the core ofthe model At the same ... historians of economic thought The editors and contributors are all active members ofthe Japanese Society for the History of Economic Thought at the time of writing In one profound sense, they ... attention tothe prominent role ofthe justices ofthe peace and other gentlemen who tried to correct the former bad practice’ in linen manufacture, and also tothe establishment ofthe Board of Trustees,...
... with the nt sequence ofthe open reading frame (ORF) of their cDNAs and the corresponding aa sequences, in Table Summary ofthe purification of DNases I from the pancreases of three species of snake ... cloned the cDNA of each A single amino acid (aa) substitution was confirmed to affect the thermal stabilities of vertebrate DNases I and, furthermore, one ofthe postulated mechanisms whereby thermal ... regions of E climacophora DNase I cDNA were identical to those of E quadrivirgata, but 8.4% (16/189) ofthe entire nt sequence in the 3¢-UTR ofthe former was different from that ofthe latter The...