Báo cáo khoa học: Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r Structural biology docx

... 3986–3998 ª 2010 The Authors Journal compilation ª 2010 FEBS Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r Structural biology Andra ´ sLa ´ ng 1, *, ... timescale in both of the free modules. Thus, these loops are strong candidates for binding sites of other complement and ⁄ or r...

Ngày tải lên: 15/03/2014, 23:20

... to determine the amounts of glycosaminoglycans remaining in the matrix. Measurement of turnover of 35 S-labeled proteoglycans in tendon maintained in culture in medium containing varying concentrations ... that the Fig. 2. The effects of CaPPS and heparin on the percentage of each 35 S-labeled proteoglycan species remaining in the matrix of bovine tendon cu...

Ngày tải lên: 23/03/2014, 10:21

... Ca 2+ -binding sites and two Zn 2+ -binding sites per subunit, whereby the Zn 2+ ion binding to one of the sites is coordinated by residues from two homodimers. The effect of selective binding of these ... is a member of the S100 protein family, the largest subgroup within the superfamily of Ca 2+ -bind- ing EF-hand proteins. Human S100A2 is a 22 kDa homodimer, expre...

Ngày tải lên: 30/03/2014, 02:20

... b-strands A, G and H [17]. Structural nature of the TLP and transthyretin active sites One of the striking features of transthyretin is the cen- tral channel of the protein into which the THs bind. This ... involved in the oxidation of uric acid to allantoin. Certainly, the co-localization of these proteins in the peroxisomes of metazoan and plant spe...

Ngày tải lên: 07/03/2014, 00:20

... mechanism of antitumour action of BS-RNase is based on the ability of the protein to resist the neutralizing action of the cytosolic RNase inhibitor, a resistance due to the dimeric structure of the enzyme. ... devoid of toxicity as native, dimeric BS-RNase (data not shown). It is noteworthy that in the inactive MCM, MCA and MAE monomers Cys31 and Cys32, the...

Ngày tải lên: 20/02/2014, 11:20

... the 145 kDa form of GC-C and ligand responsiveness. Western blot analysis of cells cultured in the presence of swainsonine showed the presence of a band of 136 kDa, representing the partially glycosylated ... a reappearance of the 145 kDa form on the cell surface, fol- lowing processing of the endoplasmic reticulum-associated pool of the 130 kDa form. Selec...

Ngày tải lên: 08/03/2014, 08:20

... in MEDLINE at the end of 2004 (14,785,094 articles). The follow- ing sections explain in detail off-/on-line process- ing for the text retrieval system for MEDLINE. 3.1 Off-line processing: HPSG ... shows the size of the original database and the number of entries expanded by name varia- tions. Terms in MEDLINE were then identified by the longest matching of entri...

Ngày tải lên: 17/03/2014, 04:20

... determined include the MLL1 CXXC domain [22], a portion of the MLL1 TAD bound to the KIX domain of the cAMP response element-binding (CREB) binding protein (CBP) [23], a peptide from the Win motif ... coordinates two zinc ions using the two conserved CGXCXXC motifs (Fig. 2A). The zinc ions are required for the structural integrity of the protein, as mutation of any...

Ngày tải lên: 16/02/2014, 14:20

... of histone H1. These data suggest a link between PARP-1 binding to non-B DNA structures in the genome and its function in the dynamics of local modulation of chromatin structure in normal cellular ... modulation of chromatin structure and transcription mediated by nucleosome binding of PARP-1 [12], and in the determination of specificity in a retinoid si...

Ngày tải lên: 20/02/2014, 01:20

... proteins, including receptors and cytokines such as inter- leukin-1b. The present work reviewed the role of neuroinflammatory mediators in the pathophysiology of ischemic brain damage and their poten- tial ... recovery and repair. Within hours after the ischemic insult, increased levels of cytokines and chemokines enhance the expression of adhesion molecules on cere...

Ngày tải lên: 07/03/2014, 03:20