... integrin-dependentcell volume sensing and signaling integrates into the overall context of insulin signaling. Similarly, sensingof glutamine-induced hepatocyte swelling by integrinsfeeds into ... hepatocyte swelling [12,13], insu-lin-induced hepatocyte swelling is registrated by the integrin system, leading to a Src-dependent activationof the p38-type MAPK and thereby inhibition ofautophagic ... 2007 The Authors Journal compilation ª 2007 FEBS 5799[7]. On the other hand, hyperosmotic shrinkage pre-vents insulin-induced hepatocyte swelling and proteo-lysis inhibition, indicating that...