Báo cáo khoa học: Recent insights into cerebral cavernous malformations: the molecular genetics of CCM pot

... MINIREVIEW Recent insights into cerebral cavernous malformations: the molecular genetics of CCM Florence Riant 1,2 , Francoise Bergametti 2 , Xavier ... identified in the recent years. These molecular genetics data have provided useful information for clinical care of the patients and were an important step towards the understanding of the mechanisms of...

Ngày tải lên: 15/03/2014, 10:20

... insights into cerebral cavernous malformations: the molecular genetics of CCM. FEBS J 277, 1070–1075. 11 Faurobert E & Albiges-Rizo C (2010) Recent insights into cerebral cavernous malformations: ... hemor- rhage. These features are reminiscent of the cancer ret- inoblastoma, which led to the Knudson ‘two-hit’ hypothesis. Similarly, a two-hit hypothesi...

Ngày tải lên: 15/03/2014, 10:20

... Felbor U (2008) Novel CCM1 , CCM2 , and CCM3 mutations in patients with cerebral cavernous malformations: in- frame deletion in CCM2 prevents formation of a CCM1 ⁄ CCM2 ⁄ CCM3 protein complex. ... adhesion The most recent articles strongly emphasize the role of CCM proteins on the formation of cell–cell junctions. However, we think that a control of the intera...

Ngày tải lên: 15/03/2014, 10:20

... proton from the catalytic Cys pres- ent at the N-terminus of the helix to the His of the dyad [19,50,51]. The first stage of catalysis is mediated by the highly active thiolate ion of the Cys. Biochemi- cal ... at the bottom of the subsite is conserved in ervatamins. Compared to a Ser in the equivalent position of papain, the role of Leu here is to restric...

Ngày tải lên: 18/02/2014, 16:20

... antibodies to the subunits of the yeast bc 1 complex indicated on the left side of the blots. The Western blots are shown in panels A and B and the relative amounts of each of the subunits determined ... mutant strain. However, the amounts of core protein 1 and core protein 2 were relatively unaffected. Therefore, the absence of subunit 6 appeared to alter the...

Ngày tải lên: 19/02/2014, 12:20

... molecules of the cofactor ThDP are bound in the canonical V conformation at the interface between the PYR domain and the PP domain of two subunits of the functional dimer. The main chain oxygen of G421 ... The main chain nitrogens of residues I322 and I303 interact with nitrogen atoms of the adenine ring and the c-carboxyl group of the side chain of resid...

Ngày tải lên: 06/03/2014, 11:20

... systemic haemorrhage in mice. These results emphasize the importance of the rapid homing of RVV-X into microvessels to exert its effect. The glycan structures of a number of venom glycopro- teins ... sequenced. Of these, 10 clones were found to encode the LC2 and LC1 sub- units. Others were found to encode other variants of the C-lectin-like venom proteins. The amino...

Ngày tải lên: 07/03/2014, 06:20

... the cytosol. This observation allows the further determination of the concentration of drug free in the cytosol of resistant cells. The determination of k a requires also the measurement of the ... the rate of passive diffusion of the dye through the plasma membrane. This cannot be done by the simple measurement of the increase of the fluorescence si...

Ngày tải lên: 08/03/2014, 08:20

... with the side-chain of Lys101 [24]. Consistent with the reports of the selec- tion of Lys101Glu in clinical use of efavirenz, the crystal structure of RT with this NNRTI shows a contact of the ... with a shift of 0.5 A ˚ relative to wild-type. The result of these changes is the loss of the salt bridge that links the protonated amino group of Lys101 in t...

Ngày tải lên: 16/03/2014, 13:20

... X-organs of the two species, and analy- sed the peptide content of the sinus glands by MALDI-TOF mass spectrometry to check for the presence of the peptides predicted from molecular cloning. Furthermore, ... along the neurons of the XO ⁄ SG system (Fig. 4A). Classically, the X-organ (the grouping of perikarya in which the neuropeptides are synthesized) is locate...

Ngày tải lên: 23/03/2014, 07:20