Báo cáo khoa học: Molecular basis of cytokine signalling – theme and variations docx

... on the mole- cular basis of cytokine receptor signalling – theme and variations – has three movements, like a sonata. First, we will look at the basic mechanism and the many variations realized ... 67 4–6 76. Molecular basis of cytokine signalling W. Sebald et al. 118 FEBS Journal 277 (2010) 10 6–1 18 ª 2009 The Authors Journal compilation ª 2009 FEBS T...

Ngày tải lên: 15/03/2014, 09:20

... some of the key findings that have led to our current under- standing of the molecular mode of action of glypho- sate and the molecular basis for glyphosate resistance. Structure and function of ... (Arg21, Arg111, and His138) and with the carboxylate end (Arg21 and Arg73) of GriP. Of partic- ular note is a short, 2.46-A ˚ hydrogen bond between N- e of His138 a...

Ngày tải lên: 14/02/2014, 14:20

... 102 3–1 034. N. Numa et al. Molecular basis of perinatal form of hypophosphatasia FEBS Journal 275 (2008) 272 7–2 737 ª 2008 The Authors Journal compilation ª 2008 FEBS 2737 Molecular basis of perinatal ... lane: 14 C-methylated protein markers of 200, 97.5, 66, 46 and 30 kDa, from the top of the gel. N. Numa et al. Molecular basis of perinatal form of hypophos...

Ngày tải lên: 07/03/2014, 05:20

... is a b-sandwich, containing a five-stranded sheet and a b-hairpin (both of which are anti-parallel). The third domain is a b-sandwich composed of one four- stranded sheet and one three-stranded ... cell specificities of aerolysin and e-toxin, and the different function of LSL, is the result of the different structures and properties of these domains. The second and third...

Ngày tải lên: 14/03/2014, 22:20

... the yeast and amebal PGKs. 3D predicted model of EhPGK Predicted 3D structures of the EhPGK were obtained by means of modeller software (see Fig. S1 for details on these models) and molecular ... mechanism and determinants of thermal stability. Structure 5, 147 5–1 483. 34 Scopes RK (1978) Binding of substrates and other anions to yeast phosphoglycerate kinase. Eur J Bio...

Ngày tải lên: 16/03/2014, 01:20

... symptoms, and propagation of infectious prions, the latter giving rise to the typical transmissibility within and between species [ 1–5 ]. The formation of the disease-associated isoform of prion protein ... the cellular func- tion of the normal cellular isoform of prion protein is not exactly known, the impact of gain of toxic function or loss of function, or a combinat...

Ngày tải lên: 30/03/2014, 09:20

... comparative analysis of thermodynamic parameters of ESAT–CFP-10, Rv0287–Rv0288, and Rv3619c–Rv3620c. The stoichiome- try of interaction and values of K b and DH were determined by ITC. DG and DS were ... contents of Rv3619c, Rv3620c and the 1 : 1 complex were approximately 33%, 34% and 70%, respectively. The secondary structure of Rv3619c–Rv3620c was very similar to th...

Ngày tải lên: 22/03/2014, 16:21

... suppressalis EcR-A Fig. 2. Alignment of the primary sequences of (A) A ⁄ B regions of EcRs, (B) E regions of EcRs, (C) A ⁄ B regions of USPs and RXRs, and (D) E regions of USPs and RXRs. Alignments were ... region) and E ⁄ F (ligand- or hormone-binding domain) [8,9]. The X-ray crystal structures of the ligand-binding domains of EcR, USPs and RXRs have been resolved i...

Ngày tải lên: 30/03/2014, 04:20

... arrowheads to the right of the gels, and their complexes 1–4 to the left. Bands 1 and 2 correspond to 1 : 2 and 1 : 1 DD–DDR complexes, respectively, and bands 3 and 4 to GD–GDR and GD–DDR complexes, ... dehydratase (A–D) and apoglycer- ol dehydratase (E–H) (0.74 unit) were preliminarily incubated without (broken lines in A,E) and with (solid lines) 23 lg of GDR (B–D) a...

Ngày tải lên: 16/03/2014, 05:20

... the protein databank as 2AOD (WT–p2-NC), 2AOC (I84V–p2-NC), 2AOE (V82A– CA-p2), 2AOF (V82A–p1-p6), 2AOG (V82A–p2-NC), 2AOH (V82A–p6-PR), 2AOI (WT–p1-p6) and 2AOJ (WT–p6-PR). Acknowledgements This ... complexes PR–p1-p6, PR V82A –p1-p6, PR–p6 pol -PR and PR V82A –p6 pol -PR, as described previously [25]. Overall comparison of the crystal structures Comparison of ligand bound and unli...

Ngày tải lên: 30/03/2014, 20:20