Báo cáo khoa học: Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex doc

... (1997) The restriction point and control of cell proliferation. Current Opin Cell Biol 9, 768–772. 3 Blagosklonny MV & Pardee AB (2002) The restriction point of the cell cycle. Cell Cycle ... description of regulation of the G1-S transition of the mammalian cell cycle. Biotechnol Bioeng 65, 631–637. 8 Aguda B & Tang Y (1999) The kinetic...

Ngày tải lên: 15/03/2014, 09:20

... record (a) the text’s score accord- ing to the variation model and (b) the set of deci- sions made at each of the selected choice points in the generator. Finally, for a random sample of the generated ... the analysis of the residuals gave a normal graph. 4 Controlling the Generator These regression equations characterise the way in which generator decisions in...

Ngày tải lên: 31/03/2014, 03:20

... models as a result of the complexity of the long-range interactions encountered in sheets. The crucial point here is the synthesis of the stable turn motif that finally nucleates the pleated sheet ... the directionality of the b-peptide chain. The orientation of the H-bonds is closely connected to the number of atoms comprising the H-bonded ring Fig. 1. Ge...

Ngày tải lên: 31/03/2014, 07:20

... techniques for the benefit of the hearing impaired in Japan. The project is supported by the Telecommunications Advancement Organisation of Japan with the help of the ministry of Posts and ... al. 1996). Therefore we need to summarise the news texts to some extent, and then show them on the screen. The aim of the research on automatic text summarisation...

Ngày tải lên: 08/03/2014, 06:20

... for the open and closed forms of the dimanganese cluster. Loss of one of the solvent bridges fundamentally alters the properties of the manganese ions and their electronic interactions within the ... interactions within the cluster core. The change in the sign of the exchange coupling in the closed/open 2 transformation may be traced to the loss of one of...

Ngày tải lên: 08/03/2014, 08:20

... internalization of the protein across the phospholipid bilayer barrier. a-Sarcin, the best characterized member of the family of fungal ribotoxins, directly interacts with the phosphlipids of the cell membrane ... added to the cells. After 20 h incubation, for evaluation of viable cell number, the cells were further incubated for 2 h in the presence of 0.25 m...

Ngày tải lên: 23/03/2014, 12:20

... subtracted the control traces from the traces recorded in the presence of the toxin. The amplitude of these toxin-induced currents was analyzed by plotting the value 3 ms after the onset of the depolarizing ... in the control, but, in the presence of the toxin, we were forced to add another slower time constant while maintaining unaltered the fast time const...

Ngày tải lên: 23/03/2014, 12:20

... be expected to have the largest effect on the expansion of the cavity. On the other hand, the size of the side-chain of the amino acid residue used to substitute for serine 140 of S. solfataricus ... FARM block the elongation of the prenyl chain at the bottom of the cavity in the enzyme. Thus, additional mutations were introduced into mutant H139A to deter-...

Ngày tải lên: 23/03/2014, 17:21

... expected, the substituted Lys forms a hydrogen bond with the substrate, stabilizing the complex. The enzymatic activity of S329K is 2% of that of the wild-type enzyme. The catalytic site structure of ... those of Mn1 (14.6, 17.7, 22.2 and 15.5 A ˚ 2 ), supporting the high mobility of Mn2 in the enzyme. The displacement of Mn2 does not affect greatly the over...

Ngày tải lên: 29/03/2014, 08:20

... increases O 2 affinity as the residue swings out of the pocket [16]. In human and mouse Ngb this opening of the haem pocket also involves the rupture of the bond between a haem propionate and the side chain of LysE10, ... 2C). The apparent heat of oxygenation for each globin was calculated from the slope of the van’t Hoff plot, using P 50 values obtained at pH 7.4...

Ngày tải lên: 30/03/2014, 11:20