... Nickel and the Skin: Absorption, Immunology, Epidemiology, and Metallurgy interacting with tissue protein. They form bonds that range from the fully ionizedto the fully chelated, and have the ... with the skin and the formation of soluble, skin-diffusiblesalts, the phenomenon of skin penetration, induction and elicitation of allergicreactions, diagnosis, tolerance, and epidemiology. The ... identified by skin patch testing, and the affected patient may avoid further exposure, the cause for NAH is multifactorial;total avoidance of the allergen in the workplace and in private life is difficult...